| PUBLICATIONS (Ranked by impact factor of the journal) | Induction of ICOS+CXCR3+CXCR5+ TH Cells Correlates with Antibody Responses to Influenza Vaccination Researchers identified the type of CD4+ T cells associated with protective antibody responses after seasonal influenza vaccinations. The administration of trivalent split- virus influenza vaccines induced a temporary increase of CD4+ T cells expressing ICOS, which peaked at day 7, as did plasmablasts. [Sci Transl Med] Abstract | Press Release CD62L Is Critical for Maturation and Accumulation of Murine Hepatic NK Cells in Response to Viral Infection Investigators found that murine NK cells in various organs could be divided into CD62L− and CD62L+ subsets, the latter of which were less abundant in the liver and exhibited a relatively mature NK cell phenotype and a stronger cytotoxic function. [J Immunol] Abstract Enhanced Immunogenicity of a Tricomponent Mannan Tetanus Toxoid Conjugate Vaccine Targeted to Dendritic Cells via Dectin-1 by Incorporating β-Glucan In a previous attempt to generate a protective vaccine against Candida albicans, a β-mannan tetanus toxoid conjugate showed poor immunogenicity in mice. To improve the specific activation toward the fungal pathogen, the authors aimed to target Dectin-1, a pattern-recognition receptor expressed on monocytes, macrophages, and dendritic cells. [J Immunol] Abstract M2e-Displaying Virus-Like Particles with Associated RNA Promote T Helper 1 Type Adaptive Immunity against Influenza A The ectodomain of influenza A matrix protein 2 (M2e) is a candidate for a universal influenza A vaccine. The authors used recombinant Hepatitis B core antigen to produce virus-like particles presenting M2e (M2e- VLPs). They produced the VLPs with and without entrapped nucleic acids and compared their immunogenicity and protective efficacy. [PLoS One] Full Article The Degree of Helicobacter pylori Inflammation Is Manipulated by the Pre-Infection Host Microbiota Researchers demonstrated that one previously unappreciated parameter influencing H. pylori disease outcome is variation in pre-infection host microbiota. Utilizing a mouse model, they altered the microbiota by antibiotic treatment and found that these alterations resulted in significantly lowered H. pylori-triggered inflammation. [Infect Immun] Abstract | Press Release HIV Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design Using computational models, scientists have developed an approach to translate available viral sequence data into quantitative landscapes of viral fitness as a function of the amino acid sequences of its constituent proteins. Predictions emerging from their computationally defined landscapes for the proteins of HIV-1 clade B Gag were positively tested against new in vitro fitness measurements and were consistent with previously defined in vitro measurements and clinical observations. [Immunity] Abstract | Press Release Engineering HIV Envelope Protein to Activate Germline B Cell Receptors of Broadly Neutralizing Anti-CD4 Binding Site Antibodies Scientists showed that envelope glycoprotein (Env) immunogens fail to engage the germline-reverted forms of known broadly neutralizing antibodies that target the CD4-binding site. However, they found that the elimination of a conserved glycosylation site located in Loop D and two glycosylation sites located in variable region 5 of Env allows Env-binding to, and activation of, B cells expressing the germline-reverted BCRs of two potent broadly neutralizing antibodies, VRC01 and NIH45-46. [J Exp Med] Abstract Influenza, But Not HIV-Specific CTL Epitopes, Elicits Delayed-Type Hypersensitivity (DTH) Reactions in HIV-Infected Patients The authors studied the possibility of using defined HLA-A*02:01-restricted cytotoxic T lymphocyte (CTL) epitopes from influenza matrix protein (GL9, GILGFVFTL) and HIV Gag p17 (SL9, SLYNTVATL) to elicit a cutaneous DTH reaction. Their results show that the GL9 but not the SL9 epitope was able to induce a DTH reaction. [Eur J Immunol] Abstract Interleukin-27 Is a Potent Inhibitor of cis HIV-1 Replication in Monocyte-Derived Dendritic Cells via a Type I Interferon-Independent Pathway Interleukin-27 (IL-27) has been shown to be a potent inhibitor of HIV-1 infection in CD4+ T cells and macrophages. Investigators examined whether IL-27 has a similar inhibitory effect on HIV-1 replication in dendritic cells (DCs). Monocytes were differentiated into immature DCs and mature DCs with standard techniques using a combination of GM-CSF, IL-4 and LPS. [PLoS One] Full Article
Don’t forget to subscribe to our sister publications: Human Immunology News and Immune Regulation News! |
| REVIEWS | T Cell-Mediated Host Immune Defenses in the Lung This review focuses on the recent advances in understanding how T lymphocytes mediate pulmonary host defenses against bacterial, viral, and fungal pathogens. [Annu Rev Immunol] Abstract The Immune Response in Tuberculosis This review aims to summarize what is known about the immune response in tuberculosis, in human disease, and in a range of experimental models, all of which are essential to advancing the mechanistic knowledge base of the host-pathogen interactions that influence disease outcome. [Annu Rev Immunol] Abstract Visit our reviews page to see a complete list of reviews in the infectious disease research field. |
|
|
|