Peroxisome Proliferator-Activated Receptor γ-Mediated Increase in Glucose Availability Sustains Chronic Brucella abortus Infection in Alternatively Activated Macrophages Investigators showed that the intracellular pathogen Brucella abortus survives and replicates preferentially in alternatively activated macrophages, which are more abundant during chronic infection. [Cell Host Microbe] Abstract | Press Release Neutralizing Antibodies against Previously Encountered Influenza Virus Strains Increase Over Time: A Longitudinal Analysis Although it is known that immunological memory developed against previously encountered influenza A virus strains affects the outcome of subsequent infections, exactly how sequential exposures to antigenically variant viruses shape the humoral immune response in humans remains poorly understood. To address this important question, researchers performed a longitudinal analysis of antibody titers against various pandemic and seasonal strains of influenza virus spanning a 20-year period with samples from 40 individuals obtained from the Framingham Heart Study. [Sci Transl Med] Abstract Superantigens Are Critical for Staphylococcus aureus Infective Endocarditis, Sepsis, and Acute Kidney Injury The authors investigated the role of superantigens (SAgs) in the development of lethal sepsis, infective endocarditis, and kidney infections. SAgs cause toxic shock syndrome, but it is unclear if SAgs contribute to infective endocarditis and kidney infections secondary to sepsis. [mBio] Full Article | Press Release Persistence of the Bacterial Pathogen Granulibacter bethesdensis in Chronic Granulomatous Disease Monocytes and Macrophages Lacking a Functional NADPH Oxidase The authors examined phagocytic killing by primary human monocytes and monocyte-derived macrophages. Cells from both normal and chronic granulomatous disease subjects internalized G. bethesdensis similarly. G. bethesdensis stimulated superoxide production in normal monocytes, but to a lesser degree than in normal polymorphonuclear leukocytes. [J Immunol] Abstract Differential Lung NK Cell Responses in Avian Influenza Virus Infected Chickens Correlate with Pathogenicity Since natural killer (NK) cells have been shown to play an important role in influenza-specific immunity, scientists hypothesized that NK cells are involved in this difference in pathogenicity. To investigate this, the role of chicken NK-cells in low pathogenicity avian influenza virus infection was studied. [Sci Rep] Full Article HIV HIV Latency and Integration Site Placement in Five Cell-Based Models Researchers compared data from five different in vitro models of latency based on primary human T cells or a T cell line. Cells were infected in vitro and separated into fractions containing proviruses that were either expressed or silent/inducible, and integration site populations sequenced from each. [Retrovirology] Abstract | Full Article Gag-Positive Reservoir Cells Are Susceptible to HIV-Specific Cytotoxic T Lymphocyte Mediated Clearance Scientists examined if superinfected resting CD4+T cells from elite controllers (EC) express HIV Gag without producing infectious virus and the susceptibility of these cells to cytotoxic T lymphocytes. They found that resting CD4+T cells expressed HIV Gag and were cleared by autologous CD8+T cells from EC. [PLoS One] Full Article The Potential Role of CD16+ Vγ2Vδ2 T Cell-Mediated ADCC in Control of HIV-1 Disease Investigators found that although CD16+ Vγ2Vδ2 (Vδ2) T cell subset hardly participated in phosphoantigen responses dominated by CD16- Vδ2 T cell subset, the potency of ADCC function of Vδ2 T cells was correlated with the frequency of CD16+ subset. [AIDS Res Hum Retrovir] Abstract Production of Human Antibodies by In Vitro Immunization Using a Fusion Protein Containing the Transcriptional Transactivator of HIV-1 The authors investigated whether the transcriptional transactivator of human immunodeficiency virus, which possesses numerous biological activities, is able to trigger antibody secretion when incubated with human peripheral blood mononuclear cells. [J Immunol Methods] Abstract |