Immunology of Infectious Disease News Volume 10.00 | Jan 5 2022

Justin.choi

May 12, 2022

2022-01-05 | IIDN 10.00

Immunology of Infectious Disease News by STEMCELL Technologies

Vol. 10.00 – 5 January, 2022

TOP STORY

Complement Activation Induces Excessive T Cell Cytotoxicity in Severe COVID-19

Researchers identified highly activated, CD16⁺ T cells with increased cytotoxic functions in severe COVID-19.
[Cell]

Abstract Full Article

With ImmunoCult™ Dendritic Cell Culture Kit, you can generate immature, as well as mature, dendritic cells from human monocytes.

PUBLICATIONSRanked by the impact factor of the journal

SARS-CoV-2

Inhaled Remdesivir Reduces Viral Burden in a Nonhuman Primate Model of SARS-CoV-2 Infection

Scientists investigated the pharmacokinetics and efficacy of remdesivir administered by head dome inhalation in African green monkeys.
[Science Translational Medicine]

Full Article

Establishment of Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of SARS-CoV-2 Infection

A proteome map of COVID-19 skin was established and the susceptibility of human-induced pluripotent stem cell-derived skin organoids with hair follicles and nervous system was investigated, to SARS-CoV-2 infection.
[Advanced Science]

Full Article

A Virus-Specific Monocyte Inflammatory Phenotype Is Induced by SARS-CoV-2 at the Immune–Epithelial Interface

A strong response was induced in monocytes and B cells, with a SARS-CoV-2–specific inflammatory gene cluster distinct from that seen in influenza A or Ebola virus-infected cocultures, and which reproduced deviations reported in blood or lung myeloid cells from COVID-19 patients.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

SARS-CoV-2 Treatment Effects Induced by ACE2-Expressing Microparticles Are Explained by the Oxidized Cholesterol-Increased Endosomal pH of Alveolar Macrophages

Investigators showed that ACE2-overexpressing A549 cell-derived microparticles were a potential therapeutic agent against SARS-CoV-2 infection.
[Cellular & Molecular Immunology]

Full Article

Safety, Immunogenicity, and Protection Provided by Unadjuvanted and Adjuvanted Formulations of a Recombinant Plant-Derived Virus-Like Particle Vaccine Candidate for COVID-19 in Nonhuman Primates

Scientists reported the immunogenicity and protection induced in rhesus macaques by intramuscular injections of a virus-like particle bearing a SARS-CoV-2 spike protein vaccine candidate formulated with or without Adjuvant System 03 or cytidine-phospho-guanosine 1018.
[Cellular & Molecular Immunology]

Full Article

ID2 Inhibits Innate Antiviral Immunity by Blocking TBK1- and IKKε-Induced Activation of IRF3

The authors reported that inhibitor of DNA binding protein 2 negatively regulated antiviral innate immune responses.
[Science Signaling]

Abstract

MORE IMMUNOLOGY OF INFECTIOUS DISEASE

The Transcription Factor KLF14 Regulates Macrophage Glycolysis and Immune Function by Inhibiting HK2 in Sepsis

Investigators provided evidence to support the function of KLF14, a novel Krüppel-like transcription factor, in the regulation of glycolysis and the immune function of macrophages during sepsis.
[Cellular & Molecular Immunology]

Full Article

Implications of the Accumulation of CXCR5⁺ NK Cells in Lymph Nodes of HIV-1 Infected Patients

Lymphocytes and tissue sections of lymph node were collected from 11 HIV-1 positive antiretroviral therapy-naive and 19 HIV-1 negative donors.
[Ebiomedicine]

Abstract

Adults with Plasmodium falciparum Malaria Have Higher Magnitude and Quality of Circulating T-Follicular Helper Cells Compared to Children

The authors undertook a comprehensive study of T-follicular helper cells, along with B cells and antibody induction in children and adults with malaria.
[Ebiomedicine]

Full Article

Designing a Multi-Epitope Vaccine to Provoke the Robust Immune Response against Influenza A H7N9

Researchers reported the design of a multi-epitope vaccine against Hemagglutinin and Neuraminidase proteins of H7N9 Influenza A virus by prediction of Cytotoxic T lymphocyte, Helper T lymphocyte, IFN-γ and B cell epitopes.
[Scientific Reports]

Full Article

YAP1 Induces Marrow Derived Suppressor Cell Recruitment in Chlamydia trachomatis Infection

Scientists explored the role of marrow derived suppressor cells in the immune escape mechanism of Chlamydia trachomatis.
[Immunology Letters]

Abstract

Towards Large-Scale Identification of HLA-Restricted T Cell Epitopes from Four Vaccine Candidate Antigens in a Malaria Endemic Community in Ghana

Investigators identified immunodominant portions of four malaria vaccine candidate antigens using peripheral blood mononuclear cells from adults with life-long exposure to malaria parasites.
[Vaccine]

Full Article

The Effect of Age on CD4⁺ T Cell Recovery in HIV-Suppressed Adult Participants: A Sub-Study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) Study

Researchers established a semi-mechanistic population model simultaneously describing naïve and memory CD4⁺ T cell trajectories in 122 participants.
[Immunity & Ageing]

Full Article

REVIEWS

Distribution of +874T/A IFN-γ and -509C/T TGF-β1 Single Nucleotide Polymorphisms in Human Immunodeficiency Virus-infected Thais

The authors examined distribution of the well-characterized +874 T/A IFN-γ and -509C/T TGF-β1 single nucleotide polymorphisms in Thai people living with HIV.
[Journal of Medical Virology]

Abstract

Mesenchymal Stromal Cells: A Possible Reservoir for HIV-1?

Mesenchymal stem cells appear to have the potential to contribute to the HIV-1 reservoir. Further studies are needed using techniques such as those used to prove that cluster of differentiation (CD)4⁺ T cells constitute an HIV-1 reservoir before a reservoir function can definitively be ascribed to MSCs.
[Stem Cell Reviews and Reports]

Full Article Graphical Abstract

COVID-19: Systemic Pathology and Its Implications for Therapy

Scientists summarize the physiological and pathological damage of SARS-CoV-2 to these systems and its molecular mechanisms followed by clinical manifestation.
[International Journal of Biological Sciences]

Full Article Graphical Abstract

INDUSTRY AND POLICY NEWS

Pfizer and BioNTech Sign New Global Collaboration Agreement to Develop First mRNA-based Shingles Vaccine

Pfizer, Inc. and BioNTech SE announced a new research, development and commercialization collaboration to develop a potential first mRNA-based vaccine for the prevention of shingles.
[Pfizer, Inc.]

Press Release

VBI Vaccines Announces Dosing of First Patient in Second Phase II Study in Chronic Hepatitis B Patients as Part of Expansion of Clinical Collaboration With Brii Bio

VBI Vaccines, Inc. announced that the first patient has been dosed in a second Phase IIa/IIb clinical study evaluating VBI-2601, an immunotherapeutic candidate targeting chronic hepatitis B virus.
[VBI Vaccines, Inc.]

Press Release

FEATURED EVENT

Complement Activation Induces Excessive T Cell Cytotoxicity in Severe COVID-19

Inhaled Remdesivir Reduces Viral Burden in a Nonhuman Primate Model of SARS-CoV-2 Infection

Establishment of Human Pluripotent Stem Cell-Derived Skin Organoids Enabled Pathophysiological Model of SARS-CoV-2 Infection

A Virus-Specific Monocyte Inflammatory Phenotype Is Induced by SARS-CoV-2 at the Immune–Epithelial Interface

SARS-CoV-2 Treatment Effects Induced by ACE2-Expressing Microparticles Are Explained by the Oxidized Cholesterol-Increased Endosomal pH of Alveolar Macrophages

Safety, Immunogenicity, and Protection Provided by Unadjuvanted and Adjuvanted Formulations of a Recombinant Plant-Derived Virus-Like Particle Vaccine Candidate for COVID-19 in Nonhuman Primates

ID2 Inhibits Innate Antiviral Immunity by Blocking TBK1- and IKKε-Induced Activation of IRF3

The Transcription Factor KLF14 Regulates Macrophage Glycolysis and Immune Function by Inhibiting HK2 in Sepsis

Implications of the Accumulation of CXCR5⁺ NK Cells in Lymph Nodes of HIV-1 Infected Patients

Adults with Plasmodium falciparum Malaria Have Higher Magnitude and Quality of Circulating T-Follicular Helper Cells Compared to Children

Designing a Multi-Epitope Vaccine to Provoke the Robust Immune Response against Influenza A H7N9

YAP1 Induces Marrow Derived Suppressor Cell Recruitment in Chlamydia trachomatis Infection

Towards Large-Scale Identification of HLA-Restricted T Cell Epitopes from Four Vaccine Candidate Antigens in a Malaria Endemic Community in Ghana

The Effect of Age on CD4⁺ T Cell Recovery in HIV-Suppressed Adult Participants: A Sub-Study from AIDS Clinical Trial Group (ACTG) A5321 and the Bone Loss and Immune Reconstitution (BLIR) Study

Distribution of +874T/A IFN-γ and -509C/T TGF-β1 Single Nucleotide Polymorphisms in Human Immunodeficiency Virus-infected Thais

Mesenchymal Stromal Cells: A Possible Reservoir for HIV-1?

COVID-19: Systemic Pathology and Its Implications for Therapy

Pfizer and BioNTech Sign New Global Collaboration Agreement to Develop First mRNA-based Shingles Vaccine

VBI Vaccines Announces Dosing of First Patient in Second Phase II Study in Chronic Hepatitis B Patients as Part of Expansion of Clinical Collaboration With Brii Bio

AACR: Precision Prevention, Early Detection, and Interception of Cancer

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Research Scientist – Virus-Host Interactions and HIV

Assistant Professor – Animal and Human Pathogens

Research Assistant – Vaccine Development

PhD Project – Immune Responses to SARS-CoV-2

Research Associate – HIV Replication

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