 | | Vol. 10.01 – 12 January, 2022 |
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| Researchers compared SARS-CoV-2-specific antibody and T cell responses between older adults and a younger control group after receiving two doses of BNT162b2.
[Nature Microbiology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators established a lethal animal model using BALB/c mice and a mouse-passaged isolate from a European lineage of SARS-CoV-2.
[Science Advances] |
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| Researchers investigated and characterized the tightly orchestrated virus assembly by visualizing the spatiotemporal dynamics of the four structural SARS-CoV-2 proteins at high resolution.
[Science Advances] |
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| Scientists assessed the influence of COVID-19 plasma hypercytokinemia on the functional responses of myeloid immune cells upon bacterial challenges from acute-phase COVID-19 patients and their corresponding recovery (rec)-phase.
[PLoS Pathogens] |
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| IgG from plasma of Ad26.COV2.S vaccinated individuals was purified and transferred into naïve golden Syrian hamster recipients, followed by intra-nasal challenge of the hamsters with SARS-CoV-2.
[NPJ Vaccines] |
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| According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.
[Frontiers in Immunology] |
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| The authors connected the circulating protein GP73 with enhanced hepatic gluconeogenesis during SARS-CoV-2 infection.
[Nature Metabolism] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers showed the administration of allogeneic human peripheral blood natural killer cells delays viral rebound following interruption of anti-retroviral therapy in humanized mice infected with HIV-1.
[Nature Communications] |
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| Scientists showed CD1b-mycolipid tetramers revealed a hierarchy in which circulating T cells expressing CD4 or CD8 co-receptor stain with a higher tetramer mean fluorescence intensity than CD4-CD8– T cells.
[Nature Communications] |
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| Researchers characterized an unknown protein encoded by phospholipase A2 inhibitor and LY6/PLAUR domain-containing (PINLYP) gene that interacted with TBK1 and induced type I IFN in a TBK1- and IRF3-dependent manner.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists reported that NRP-1, encoding transmembrane protein neuropilin-1, was highly expressed in macrophages and dendritic cells but not CD4+ T cells, serving as an anti-HIV factor to inhibit the infectivity of HIV-1 progeny virions.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers studied CD4/CD8 over time to determine whether it predicted risk for select comorbidities and mortality among aging people with HIV with viral suppression.
[AIDS] |
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| Using RNA-Seq, the authors explored CD4 T cell gene expression to identify evidence of a mechanism that might underpin virological rebound and lead to discovery of associated biomarkers.
[Scientific Reports] |
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| Scientists review recent efforts to gain a better molecular and cellular understanding of anti-Plasmodium falciparum circumsporozoite protein B cell responses in humans and discuss ways to overcome limitations in the induction of stable titers of high-affinity antibodies.
[Journal of Experimental Medicine] |
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| The authors discuss the emerging understanding of how SARS-CoV-2 and host-derived molecules activate specific pattern recognition receptors to elicit protective interferon responses and pathological cytokine responses.
[Science Immunology] |
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| Scientists discuss the interplay between lung endothelial cell, immune cells and Mycobacterium tuberculosis (Mtb) and argue that modeling these interactions is of key importance to unravel early events during Mtb infection.
[Thorax] |
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| The UK is experiencing its “largest ever” outbreak of avian influenza, BBC News reported in December, with more than 60 cases since the first report of infected swans in October.
[The Scientist] |
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| Tedros Adhanom Ghebreyesus, the director-general of the World Health Organization (WHO), is all but ensured to lead the organization for a second term, from 2022 to 2027, because he is the only candidate in the race.
[Nature News] |
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| First Wave BioPharma, Inc. announced that it has completed enrollment for Part II of the RESERVOIR Phase II trial evaluating FW-COV as an outpatient treatment for COVID-19-related gastrointestinal infections.
[First Wave BioPharma, Inc.] |
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| KI researcher Marcus Buggert has been awarded the prestigious ERC Starting Grant for his research on human cell-mediated immunity against virus diseases.
[Karolinska Instituet] |
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| February 6 – 10, 2022
Banff, Alberta, Canada |
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| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
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| | Pfizer, Inc. – New York, New York, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | University of Florida – Gainesville, Florida, United States |
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| | Centre for Immunology & Infection Limited – Hong Kong, China |
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