 | | Vol. 10.02 – 19 January, 2022 |
| |
|
|
| Following two doses, sera had over a 22-fold reduced neutralizing titers against Omicron compared to Wuhan pseudovirus.
[Science] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Researchers discovered a new STING agonist, CF501, and found that CF501-adjuvanted RBD-Fc vaccine elicited significantly stronger neutralizing antibody and T cell responses than Alum- and cGAMP-adjuvanted RBD-Fc in mice.
[Cell Research] |
|
|
|
| To study the biology afucosylated IgG immune complexes, the authors developed an in vivo model that revealed that human IgG-Fc gamma receptor interactions could regulate inflammation in the lung.
[Science Translational Medicine] |
|
|
|
| Investigators showed that three amino acid substitutions in an engineered soluble ACE2 protein markedly augmented the affinity for the S protein of the SARS-CoV-2 WA-1/2020 isolate and multiple VOCs: B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta).
[Nature Chemical Biology] |
|
|
|
| Scientists described the isolation of a nanobody that interacted simultaneously with two RBDs from different spike trimers of SARS-CoV-2, rapidly inducing the formation of spike trimer–dimers leading to the loss of their ability to attach to the host cell receptor, ACE2.
[Nature Communications] |
|
|
|
| Researchers elucidated the structure, function and molecular dynamics of a BriSΔ variant spike providing mechanistic insight into how the deletion correlated to viral cell tropism, ACE2 receptor binding and infectivity of this SARS-CoV-2 variant.
[Nature Communications] |
|
|
|
| The authors comprehensively illustrated the capacity of Adeno-associated virus (AAV) vectors co-expressing a cocktail of three short hairpin RNAs directed against the SARS-CoV-2 RdRp and N genes as versatile and effective antivirals.
[Molecular Therapy] |
|
|
|
| Investigators compared the early immune responses against AZD1222 and BNT162b2. SARS-CoV-2 seronegative participants received a single dose of either vaccine and were analyzed for immune cell, effector T cell, and antibody dynamics.
[BMC Medicine] |
|
|
|
| Scientists presented a standardized primary alveolar cell culture method for establishing a human alveolar epithelium model that can recapitulate viral infection and cellular plasticity.
[Communications Biology] |
|
|
|
| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | Investigators found that macrophage citrulline declined rapidly after interferon gamma (IFN-γ) and/or lipopolysaccharide stimulation, which was required for efficient proinflammatory signaling activation.
[Molecular Cell] |
|
|
|
| The authors demonstrated that lymph node CD169+ macrophages were dependent on direct lymphotoxin beta receptor signaling.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Using both wild-type and alpha-synuclein (αS) knockout mice, researchers showed that αS was a critical mediator of inflammatory and immune responses.
[Cell Reports] |
|
|
|
| Using miRNA microarray profiling, investigators characterized the expression profile of naive and in vivo generated murine effector antiviral CD8+ T cells.
[Journal of Immunology] |
|
|
|
| Aiming to develop an effective vaccine with rapid production, robust immunogenicity, and high protective efficiency, a DNA vaccine was designed by fusing influenza virus hemagglutinin (HA) with self-assembled ferritin nanoparticles, denoted as HA-F.
[Journal of Leukocyte Biology] |
|
|
|
|
| The author discusses our current understanding of SARS-CoV-2 infections in children and hypothesize that a life history and energy allocation perspective might offer an additional explanation to mild infections, viral dynamics and the higher incidence of rare multisystem inflammatory syndromes in children and young people.
[Immunity] |
|
|
|
| Investigators detail the novel cellular sensors that are dependent on K63 ubiquitination for their function in the immune signaling network.
[Trends in Immunology] |
|
|
|
| Scientists present an overview of neutrophil heterogeneity and its impact on the course and severity of viral respiratory infectious diseases.
[Journal of Leukocyte Biology] |
|
|
|
|
| On 1 November, the global death toll from the COVID-19 pandemic passed 5 million, official data suggested. It has now reached 5.5 million. But that figure is a significant underestimate. Records of excess mortality — a metric that involves comparing all deaths recorded with those expected to occur — show many more people than this have died in the pandemic.
[Nature News] |
|
|
|
| The FDA expects to take part in an internationally coordinated program aimed at deciding if, when, and how to update Covid-19 vaccines. The approach would ensure decisions are not left solely to individual vaccine manufacturers.
[STAT News] |
|
|
|
| Pfizer aims to have an Omicron-specific COVID-19 vaccine ready by March. Assuming it gains approval, it will mark the first revision of its mRNA vaccine Comirnaty since the initial Emergency Use Authorization of the vaccine by the FDA on 11 December 2020.
[Nature News] |
|
|
|
|
| January 30 – February 2, 2022
Keystone Resort, Keystone, Colorado, United States |
|
|
|
|
|
| | Scripps Research Institute – La Jolla, California, United States |
|
|
|
| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
|
|
|
| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
|
|
|
| | University of Florida – Gainesville, Florida, United States |
|
|
|
| | Centre for Immunology & Infection Limited – Hong Kong, China |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
