 | | Vol. 10.02 – 26 January, 2022 |
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| Researchers demonstrated that breakthrough infections induced serum binding and neutralizing antibody responses that were markedly more potent, durable and resilient to spike mutations observed in variants than those in subjects who received only two doses of vaccine.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| In subjects ∼6 months post-vaccination, 90% and 87% of memory T cell responses were preserved against variants on average by AIM assay, and 84% and 85% preserved against Omicron.
[Cell] |
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| The authors described AZD7442, a combination of two mAbs, AZD8895 and AZD1061, that simultaneously bound to distinct, nonoverlapping epitopes on the spike protein receptor binding domain to neutralize SARS-CoV-2.
[Science Translational Medicine] |
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| Investigators measured neutralizing antibody responses from 104 vaccinated individuals, including those with breakthrough infections, hybrid immunity, and no infection history.
[Science Immunology] |
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| Cannabidiol (CBD) and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently blocked SARS-CoV-2 replication in lung epithelial cells.
[Science Advances] |
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| Scientists investigated prospectively humoral and cellular responses to SARS-CoV-2 mRNA vaccination in 82 patients with neuroimmunologic disorders on anti-CD20 therapy and 82 age- and sex-matched healthy controls.
[Annals of Neurology] |
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| After the first vaccination, the prevalence of IgG directed against the SARS-CoV-2 S-protein and its receptor binding domain varied from 55–95% to 100%, depending on the vaccine regimen and the SARS-CoV-2 antigen used.
[BMC Medicine] |
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| The authors demonstrated that intramuscular or intranasal vaccination of Syrian hamsters with COH04S1 induced robust Th1-biased antigen-specific humoral immunity and cross-neutralizing antibodies.
[NPJ Vaccines] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators used a mouse model of concurrent cigarette smoke exposure and H1N1 influenza infection, colony-stimulating factor (CSF)3 supplementation/receptor blockade, and single-cell RNA sequencing to investigate this relationship.
[European Respiratory Journal] |
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| Researchers showed that administration of the A2A receptor agonist CGS-21680 depleted established CD11c+T-bet+ B cells in ehrlichial-infected mice, in a B cell-intrinsic manner.
[Nature Communications] |
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| Ex vivo characterization of single Gag-specific CD4+ T cells revealed an advanced Th1 differentiation pattern in controllers, except for the CCR5 marker, which was downregulated compared to specific cells of treated patients.
[Nature Communications] |
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| Using single-cell transcriptomics and T cell receptor sequencing, scientists analyzed mononuclear cell populations in paired pleural fluid and peripheral blood of tuberculous pleural effusion patients.
[Journal of Experimental Medicine] |
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| The authors reported that dedicator of cytokinesis 2 (DOCK2) promoted indispensable antifungal innate immune signaling and proinflammatory gene expression in macrophages.
[Cellular & Molecular Immunology] |
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| Researchers investigated if xerostomia associateD with salivary gland (SG) and hepatitis C virus (HCV) infection and to characterize the structural changes in SG and saliva composition.
[Journal of Dental Research] |
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| In a humanized mouse model under HIV-1 challenge, CXCR4-disrupted CD4+ T cells were enriched in the peripheral blood and spleen, indicating survival advantage due to resistance to viral infection.
[Molecular Therapy-Methods & Clinical Development] |
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| Emerging evidence suggests that SARS-CoV-2 could trigger pyroptosis, a form of inflammatory programmed cell death characterized by the activation of inflammasomes and caspase 1 and the formation of transmembrane pores by gasdermin D.
[Autophagy] |
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| The latest hubbub is an example of both the promise of cannabinoids — components of cannabis — as potential therapies, but also the hype around them, which can far outpace the evidence that they work.
[STAT] |
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| Aligos Therapeutics, Inc. announced that the first chronic hepatitis B patient has been dosed in the multiple ascending dose portion of Study ALG-020572-401 which is evaluating antisense oligonucleotide ALG-020572.
[Aligos Therapeutics, Inc.] |
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| March 9 – 11, 2022
Melbourne, Victoria, Australia |
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| | Dalhousie University Faculty of Medicine – Halifax, Nova Scotia, Canada |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Scripps Research Institute – La Jolla, California, United States |
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| Fox Chase Cancer Center, Temple University – Philadelphia, Pennsylvania, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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