 | | Vol. 10.04 – 9 February, 2022 |
| |
|
|
| An unusual receptor binding domain (RBD)-RBD interaction in the ACE2-spike complex supported the open conformation and further reinforced ACE2 binding to the spike trimer.
[Science] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| The authors described a broadly neutralizing antibody, CC40.8, from COVID-19-convalescent donor that exhibited broad reactivity with human beta-coronaviruses.
[Science Translational Medicine] |
|
|
|
| Using pseudovirion-based and trans-complementation SARS-CoV-2 tools, scientists determined that nanobody (Nb)1–Nb2 broadly neutralized multiple SARS-CoV-2 variants at sub-nanomolar levels, including Alpha, Beta, Gamma, Delta, Lambda, Kappa, and Mu.
[Signal Transduction and Targeted Therapy] |
|
|
|
| Researchers studied neutralizing antibodies and T-cell responses targeting SARS-CoV-2 D614G , and the Beta, Delta, and Omicron variants of concern in a cohort of 60 health care workers after immunization with ChAdOx-1 S, Ad26.COV2.S, mRNA-1273 or BNT162b2.
[Science Immunology] |
|
|
|
| Investigators comprehensively analyzed the antiviral activity of all interferon-α subtypes against SARS-CoV-2 to identify the underlying immune signatures and explore their therapeutic potential.
[Proceedings of the National Academy of Sciences of the United States of America] |
|
|
|
| Scientists reported the pathogenic and immunological consequences of SARS-CoV-2 and influenza A virus H1N1 coinfection in the K18-hACE2 transgenic mouse model.
[Journal of Virology] |
|
|
|
| Using induced pluripotent stem cell derived kidney organoids, SARS-CoV-1, SARS-CoV-2 and MERS-CoV tropism, defined by the paired expression of a host receptor and protease, was identified primarily amongst proximal tubule cells.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
|
|
|
| The authors showed that DNA-encoded native-like trimer fold properly in vivo and induced autologous tier-2 neutralizing antibodies in mice.
[Nature Communications] |
|
|
|
| Investigators observed that the HIV-1 proviral landscape was different and changed with time on antiretroviral therapy across naïve and memory CD4+ T cell subsets isolated from 24 participants.
[Journal of Clinical Investigation] |
|
|
|
| Scientists showed that a clinical isolate of Rhizopus microsporus contained a Ralstonia pickettii bacterial endosymbiont required for virulence in both zebrafish and mice and that this endosymbiosis enabled the secretion of factors that potently suppressed growth of the soil amoeba Dictyostelium discoideum.
[Current Biology] |
|
|
|
| The authors developed a lymphoid organ-targeting immunomodulator by conjugating a naturally occurring, lipophilic molecule, α-tocopherol, to a potent CpG oligonucleotide adjuvant pharmacophore.
[Molecular Therapy-Nucleic Acids] |
|
|
|
| Researchers investigated whether infusion of T cells expressing an simian immunodeficiency virus-specific chimeric antigen receptor and the follicular homing receptor, CXCR5, could successfully kill viral-RNA+ cells in targeted lymphoid follicles in SIV-infected rhesus macaques.
[PLoS Pathogens] |
|
|
|
| Similar to other filoviruses, recombinant Lloviu virus formed filamentous virions and induced the formation of characteristic inclusions in the cytoplasm of the infected cells, as shown by electron microscopy.
[PLoS Pathogens] |
|
|
|
| Investigators analyzed the cytopathologic characteristics of bronchoalveolar lavage fluid in the diagnosis of HIV/AIDS-related lung disease and compared the lung disease spectrum between HIV and HIV-uninfected patients.
[BMC Pulmonary Medicine] |
|  |
|
|
|
| Understanding that antibodies play central roles in malaria immunity and systemic lupus erythematosus, the authors discuss how autoreactive B cells contribute to malaria immunity but promote systemic lupus erythematosus pathology in the absence of malaria.
[Trends in Parasitology] |
|
|
|
| Scientists review recent evidence on the role of immune checkpoints in persistent HIV infection and discuss the potential for employing immune checkpoint blockade as a therapeutic approach to target HIV persistence on antiretroviral therapy.
[Ebiomedicine] |
|
|
|
|
| Appili Therapeutics, Inc. announced it has amended its agreement with Saptalis Pharmaceuticals LLC to expand the territories in which Saptalis will commercialize ATI-1501, Appili’s liquid oral reformulation of the antibiotic metronidazole.
[Appili Therapeutics, Inc.] |
|
|
|
| Celltrion Group announced it has submitted an IND application to conduct a global Phase III clinical trial evaluating the efficacy and safety of an inhaled COVID-19 antibody cocktail therapy for patients with mild-to-moderate symptoms of COVID-19.
[Celltrion Group] |
|
|
|
|
| February 24 – February 25, 2022
Virtual |
|
|
|
|
|
| | Babraham Institute – Babraham, England, United Kingdom |
|
|
|
| | Osaka University – Osaka, Japan |
|
|
|
| | Dalhousie University Faculty of Medicine – Halifax, Nova Scotia, Canada |
|
|
|
| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
|
|
|
| | Scripps Research Institute – La Jolla, California, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
