 | | Vol. 10.05 – 16 February, 2022 |
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| Scientists longitudinally profiled SARS-CoV-2 spike-specific serological and memory B cell responses in individuals receiving either homologous or heterologous prime-boost vaccination.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators examined the neutralizing antibody response against the spike protein of five major SARS-CoV-2 variants, D614G, Alpha, Beta, Delta, and Omicron, in health care workers vaccinated with SARS-CoV-2 mRNA vaccines.
[Science Translational Medicine] |
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| Researchers reported the development of two pools of experimentally-defined SARS-CoV-2 T cell epitopes, that in combination with spike, were used to discriminate four groups of subjects with different SARS-CoV-2 infection and COVID-19 vaccine status.
[Cell Host & Microbe] |
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| The authors found that memory cells were still detectable eight months after vaccination, while antibody levels declined significantly especially in naïve subjects.
[Journal of Clinical Investigation] |
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| Scientists characterized NK cells in healthy individuals and immunocompromised patients in the course of an anti-SARS-CoV-2 BNT162b2 mRNA prospective, open-label clinical vaccine trial.
[Trends in Molecular Medicine] |
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| Investigators showed that N- and C-terminal domains of nonstructural protein 1 (Nsp1) coordinate to drive a tuned ratio of viral to host translation, likely to maintain a certain level of host fitness while maximizing replication.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists engineered standard laboratory mice to express human ACE2 via rAAV9 in vivo gene transfer, to allow in vivo assessment of SARS-CoV-2 infection
[Thorax] |
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| Researchers described a monoclonal antibody, 2G1, that neutralized all current variants of concern and had surprising tolerance to mutations adjacent to or within its interaction epitope.
[Cell Discovery] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| In monoclonal antibody-treated macaque survivors, Ebola virus disease persisted in macrophages infiltrating the brain ventricular system, including the choroid plexuses.
[Science Translational Medicine] |
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| A rationally design a live-attenuated varicella vaccine candidate, v7D, showed immunogenicity comparable to vOka both in vitro and in multiple small animal species.
[Nature Communications] |
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| Scientists showed that IL-18 was a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier.
[Nature Communications] |
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| In the absence of interferon-γ, lung innate lymphoid cells (ILC12) from mice challenged with the A/California/04/2009 H1N1 virus, containing nonfunctional viral PB1-F2, initiated a robust IL-5 response, which also led to improved tissue integrity and increased survival.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers demonstrated that functional loss of NMUR-1 had diverse effects on C. elegans innate immunity against various bacterial pathogens.
[Cell Reports] |
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| Most nucleoprotein-specific CD8 T cells in broncho-alveolar lavage and lung are tissue resident memory cells that express CD69 and downregulate CD45RA and CCR7.
[Mucosal Immunology] |
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| The frequencies of IFN-gamma producing pp38 and MEQ-specific T cell responses were determined in line N and line P2a chickens after infection with vaccine and/or virulent strains of Marek’s disease virus using both standard ex vivo and cultured chIFN-gamma ELISPOT assays.
[Frontiers in Immunology] |
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| Infected children demonstrate stronger innate immune responses compared with adults with a higher expression of genes associated with interferon signaling and the NLRP3 inflammasome.
[infectious Disease Clinics of North America] |
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| Cidara Therapeutics, Inc. announced that the FDA has accepted the company’s Investigational New Drug application for its lead flu drug-Fc conjugate, CD388 – a highly potent, long-acting antiviral immunotherapy designed to deliver universal prevention and treatment of seasonal and pandemic influenza.
[Cidara Therapeutics, Inc.] |
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| Professor Trine Hyrup Mogensen will head a major European research project which will, in collaboration with the global consortium COVID Human Genetic Effort, carry out research into why some people develop severe infections which lead to lung damage, or in some cases autoimmune diseases several weeks after they have been ill with SARS-CoV-2.
[Aarhus University] |
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| March 13 – 18, 2022
Ventura, California, United States |
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| | Florida International University – Miami, Florida, United States |
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| | Dalhousie University Faculty of Medicine – Halifax, Nova Scotia, Canada |
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| | St. Jude Children’s Research Hospital – Location |
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| | Babraham Institute – Babraham, England, United Kingdom |
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| | Osaka University – Osaka, Japan |
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