 | | Vol. 10.07 – 2 March, 2022 |
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| Scientists revealed that S protein glycosylation had site-differential effects on viral infectivity. They found that S protein generated by lung epithelial cells had glycoforms associated with increased infectivity.
[Science Translational Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers enrolled cases of pandemic chilblains in a study and performed detailed immune profiling of antibody and T cell responses.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors proposed adoptive transfer of SARS-CoV-2-specific T cells made resistant to a common immunosuppressant, Tacrolimus, for optimized performance in the immunosuppressed patient.
[Molecular Therapy-Methods & Clinical Development] |
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| Investigators hypothesized that decidual leukocytes were altered by maternal SARS-CoV-2 infection in pregnancy and that this decidual immune response was shaped by the timing of infection during gestation.
[Journal of Reproductive Immunology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers assessed the impact of a time-restricted enterobacterial challenge to long-term type 3 innate lymphoid cells (ILC3) activation in mice.
[Science] |
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| Scientists used multiphoton intravital microscopy in mouse models of hepatitis B to study the intrahepatic behavior of group 1 innate lymphoid cells (ILCs) and their cross-talk with hepatitis B virus–specific CD8+ T cells.
[Science Immunology] |
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| Researchers identified and characterized an immunosuppressant protein that was highly concentrated in the submandibular salivary gland of the bat, Myotis pilosus.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators showed that creatine supported cell-intrinsic CD8+ T cell homeostasis. They identified creatine kinase B as the creatine kinase isoenzyme that supported these T cell properties.
[Cell Reports] |
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| Researchers showed that NK cells directly killed extracellular P. aeruginosa using NK effector molecules.
[PLoS Pathogens] |
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| The authors studied urine and blood nucleocapsid antigen using a highly sensitive immunoassay in 82 patients with a SARS-CoV-2 infection proven by PCR.
[Journal of infectious Diseases] |
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| By applying phage display technology, researchers mapped the protective epitope to be in the C-terminal region of Plasmodium falciparum rhoptry-associated membrane antigen.
[Scientific Reports] |
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| The authors demonstrated that lethal or even sublethal doses of bioluminescent influenza A virus carrying the NanoLuc gene in the C-terminus of PB2 could be tracked in real-time in live mice without compromising pathogenicity.
[Scientific Reports] |
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| Along with optimization of the immunogen and vectors, the development of adjuvants based on our evolving understanding of how the innate immune system shapes vaccine responses will be essential.
[Nature Immunology] |
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| Recent findings highlight a paramount role played by the blood–brain barrier in restricting parasite passage and minimizing parasite loads in the brain.
[Trends in Parasitology] |
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| Report authors say that the coronavirus SARS-CoV-2 jumped to people from animals sold at the market on two occasions in late 2019 — but some scientists want more definitive evidence.
[Nature News] |
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| Virios Therapeutics, Inc. announced a collaboration with the Bateman Horne Center of Salt Lake City to explore the role of combination antiviral therapy in Long COVID, otherwise known as Post-Acute Sequelae of COVID-19.
[Virios Therapeutics, Inc.] |
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| March 19 – 22, 2022
Sitges, Spain |
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| | Cedars Sinai – Los Angeles, California, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Hong Kong University – Hong Kong, China |
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| | Florida International University – Miami, Florida, United States |
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| | St. Jude Children’s Research Hospital – Location |
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