 | | Vol. 10.08 – 9 March, 2022 |
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| CD8+ T expressing inhibitory killer cell immunoglobulin-like receptors cells efficiently eliminated pathogenic gliadin-specific CD4+ T cells from celiac disease patients’ leukocytes in vitro.
[Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators reported the results of the open-label, non-randomized part B of a Phase II trial in which they evaluated the safety and immunogenicity of a booster injection of 50 µg of the COVID-19 vaccine mRNA-1273 in 344 adult participants immunized 6–8 months earlier with a primary series of two doses of 50 µg or 100 µg of mRNA-1273.
[Nature Medicine] |
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| Vaccinated individuals who tested positive for SARS-CoV-2 showed higher mucosal antibody responses in nasal secretions and higher Spike protein-specific CD8+ T cell responses in peripheral blood than did vaccinated individuals who tested negative.
[Science Translational Medicine] |
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| Scientists found that bovine mucins could inhibit the infection of live cells in a concentration- and glycan-dependent manner.
[ACS Central Science] |
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| Researchers identified ORF3a as an inducer of autophagy and revealed that ORF3a localized to the ER and induced RETREG1/FAM134B-related reticulophagy through the HMGB1-BECN1 pathway.
[Autophagy] |
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| Using glycan engineering and epitope scaffolding in boosting immunogens, the authors focused murine serum antibody responses to conserved receptor binding motif and domain epitopes following SARS-CoV-2 spike imprinting.
[Cell Reports] |
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| Scientists reported the levels of neutralizing antibodies against Wuhan, Delta and Omicron variants in unimmunized infected, immunized and boosted, and infected immunized and boosted adult individuals.
[NPJ Vaccines] |
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| Researchers demonstrated that infection with the SARS-CoV-2 B.1.351 variant induced bodyweight loss and inflammatory cytokine/chemokine production in wild-type laboratory mice.
[Scientific Reports] |
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| The authors used blood transcriptomics, multiparameter flow cytometry, and T cell receptor sequencing spanning the time of incident non-severe infection in unvaccinated virus-naive individuals to identify rapid type 1 interferon (IFN) responses common to other acute respiratory viruses and cell proliferation responses that discriminate SARS-CoV-2 from other viruses.
[Cell Reports Medicine] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators found that the frequency of hepatitis B surface antigen (HBsAg)-specific CD8+ T cells was inversely correlated with expansion of monocytic myeloid-derived suppressor cells in young rather than in adult chronic hepatitis B patients.
[Journal of Experimental Medicine] |
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| Researchers found that acute Listeria monocytogenes infection produced a phenotypically and functionally complex Treg response comprising two separate suppressor cell subpopulations, with an early Treg peak occurring at 24 hour post-infection and a later peak arising by day seven.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists found that proteasomal activity generated multiple length variants of KK10, which bound TAP and human leukocyte antigen-B∗27:05.
[Cell Reports] |
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| Investigators embarked on an epitope discovery study to define a CD8+ T cell landscape for human leukocyte antigen (HLA)-A*11:01-expressing Indigenous and non-Indigenous Australian people.
[PLoS Pathogens] |
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| Researchers showed that the transcriptional co-activator and the central mediator of canonical Wnt signaling, β-catenin, inhibited HIV transcription in CD4+ T cells via TCF-4 LTR binding sites.
[PLoS Pathogens] |
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| The authors summarize recent advances of how metabolic circuits combined with epigenetic changes dictate T cell fate decisions and shape their functional states.
[Cell Metabolism] |
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| Investigators discuss what Correlates of Protections are, review the current understanding of infection-induced, vaccine-elicited and hybrid immunity to COVID-19 and summarize the current and potential future utility of SARS-CoV-2 serologic testing.
[Journal of Clinical Microbiology] |
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| Statera Biopharma, Inc. announced submission to the FDA of its pilot study protocol for STAT-205 treatment of post-acute COVID-19.
[Statera Biopharma, Inc.] |
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| Pfizer, Inc. announced that its RSV vaccine candidate, PF-06482077 or RSVpreF, received Breakthrough Therapy Designation from the FDA for prevention of RSV-associated lower respiratory tract illness in infants from birth up to six months of age by active immunization of pregnant women.
[Pfizer, Inc.] |
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| April 6 – 9, 2022
Heidelberg, Germany |
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| | Hans-Knöll-Institute – Jena, Germany |
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| | Cedars Sinai – Los Angeles, California, United States |
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| | Hong Kong University – Hong Kong, China |
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| | Florida International University – Miami, Florida, United States |
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| | St. Jude Children’s Research Hospital – Location |
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