 | | Vol. 10.10 – 16 March, 2022 |
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| Investigators observed that experimental tumor-bearing animals had high survival rates after sepsis induction, suggesting that tumors may have suppressed sepsis-associated immune overactivation, thereby alleviating sepsis.
[Advanced Materials] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists confirmed that SARS-CoV-2 viral antigen could be detected in patient peripheral blood cells (PBCs) or postmortem lung T cells, and the infectious virus could also be detected from viral antigen-positive PBCs.
[Signal Transduction and Targeted Therapy] |
| | The authors used rhesus macaques to model protective primary immune responses in tissues during mild COVID-19.
[Science Immunology] |
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| The basal layer cells of tonsil epithelial cell–derived organoids expressed molecules essential for SARS-CoV-2 entry, such as angiotensin-converting enzyme 2, transmembrane serine protease 2 and furin, being susceptible to the viral infection.
[Biomaterials] |
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| An observational study found that the abundance of innate lymphoid cells decreased more than 7-fold over the human lifespan — T cell subsets decreased less than two-fold — and is lower in males than in females.
[eLife] |
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| Scientists developed a prototype two-dose vaccine by combining the receptor binding domain antigen, via conjugation to Diphtheria toxoid.
[NPJ Vaccines] |
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| Researchers designed a lipid nanoparticle-encapsulated, nucleoside-unmodified mRNA vaccine encoding the trimerized receptor binding domain (RBD) and showed its robust capability in inducing broad and protective immune responses against wildtype and major variants of concern in the mouse model of SARS-CoV-2 infection.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators determined the structures of Pentamer bound to neuropilin 2 and a set of potent neutralizing antibodies against human cytomegalovirus (HCV).
[Science Advances] |
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| In a double-blind, randomized, placebo-controlled trial, administering a respiratory syncytial virus vaccine to pregnant mothers reduced antimicrobial prescribing among their infants by 12.9% over the first three months of life.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Intramuscularimmunization with 40 μg of outer membrane vesicles from YptbS44(pSMV13) afforded complete protection to mice against medium and high doses of pulmonary Y. pestis infection, as well as against subcutaneous infection with 5 ×105 CFU of Y. pestis.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors identified the RNA helicase DHX16 as a potential pattern recognition receptor. Silencing of DHX16 in cells and in vivo diminished type I interferon responses against influenza virus.
[Cell Reports] |
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| Scientists examined protection against Salmonella enterica infection following exposure to nonpathogenic Enterococcus faecium in the nematode Caenorhabditis elegans.
[PLoS Biology] |
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| Researchers investigated how the diversity of UL146 in Human cytomegalovirus affected its signaling and structural properties to understand why its genetic diversity is maintained across human populations.
[PLoS Pathogens] |
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| A survey was conducted in men from an HIV cohort in Taizhou, China between 2016 and 2019. A face-to-face questionnaire interview was administered, and an anal-canal swab was collected for HPV genotyping.
[BMC Infectious Diseases] |
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| Investigators analyzed the profile of regulatory T cells and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ, and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1.
[BMC Immunology] |
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| Although the vast majority of maternal immune activation model research is carried out in rodents, the nonhuman primate model has emerged in recent years as an important translational tool.
[Biological Psychiatry] |
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| The author reviews some of the key pathways including the infectious and inflammatory processes that control hematopoiesis, followed by a comprehensive review that summarizes the latest evidence and discusses how SARS-CoV-2 infection impacts hematopoiesis.
[Cellular and Molecular Life Sciences] |
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| The number of people who have died because of the COVID-19 pandemic could be roughly three times higher than official figures suggest, according to a new analysis.
[Nature News] |
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| Revelation Biosciences, Inc. announced that it has completed enrollment and dosing in Phase IIb viral challenge study to evaluate the efficacy of intranasal REVTx-99 for the preventive treatment of H3N2 influenza infection in healthy humans.
[Revelation Biosciences, Inc.] |
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| Aeterna Zentaris, Inc. announced it has expanded the scope of its existing research program with the Julius-Maximilians-University Wuerzburg, on the development of COVID-19 and Chlamydia trachomatis vaccines.
[Aeterna Zentaris, Inc.] |
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| April 7 – April 9
Rome, Italy & Virtual |
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| | Gilead Sciences – Foster City, California, United States |
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| | Hans-Kn̦ll-Institute РJena, Germany |
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| | Cedars Sinai – Los Angeles, California, United States |
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| | Hong Kong University – Hong Kong, China |
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| | Florida International University – Miami, Florida, United States |
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