 | | Vol. 10.11 – 23 March, 2022 |
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| Virus-like particle and live virus assays were used to investigate neutralizing immunity against Delta and Omicron SARS-CoV-2 variants in 259 samples from 128 vaccinated individuals.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using a novel HLA-DRB1*15:01/S751 tetramer to track spike-specific CD4+ T cells, scientists showed that primary infection or vaccination induced robust S751-specific CXCR5− and cTFH cell memory responses.
[Nature Immunology] |
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| Researchers demonstrated the in vitro antiviral activity and in vivo therapeutic efficacy of GS-621763, an orally bioavailable prodrug of GS-441524, the parent nucleoside of remdesivir, which targeted the highly conserved virus RNA-dependent RNA polymerase.
[Science Translational Medicine] |
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| The authors reported SARS-CoV-2 vaccine-induced immune responses and breakthrough infections in patients with inflammatory bowel disease, who were treated either with an anti-tumor necrosis factor antibody, infliximab, or with vedolizumab targeting a gut-specific anti-integrin that did not impair systemic immunity.
[Nature Communications] |
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| Investigators reported the optimization of the production of VSV-ΔG-spike vaccine in Vero cells using the Ambr15 system.
[Biotechnology and Bioengineering] |
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| Scientists investigated whether SARS-CoV-2 caused morphological changes in the corneal sub-basal nerve plexus of post-COVID-19 patients using in vivo confocal microscopy.
[Eye] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors showed that vaccinating with simian adenovirus vector encoding conserved sequences across gt1-6 and gt-1a E2 protein with variable regions deleted sequentially in mice generated T cell and antibody responses comparable to either vaccine given alone.
[Hepatology] |
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| Using the pseudoinfectious reporter virus particle and reverse genetics systems, researchers found dual-host affiliated insect-specific flaviviruses entered vertebrate cells as efficiently as the mosquito-borne flaviviruses but failed to initiate replication.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Different T cell subpopulations have distinct characterizations and functions, and scientists revealed the high heterogeneity of susceptibility to viral infection and biological responses such as apoptosis in various CD4+ T and CD8+ T cell subsets through single-cell transcriptome analyses.
[Emerging Microbes & Infections] |
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| Researchers presented a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection.
[Immunology & Cell Biology] |
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| The authors investigated the effect of myeloid differentiation factor 88 silencing on dendritic cell function and immune response.
[Immunogenetics] |
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| The scientist covers recent developments in our understanding of the risks of SARS-CoV-2 infection in pregnancy, and how vaccination can reduce these.
[Nature Reviews Immunology] |
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| Investigators explore the potential pathogenic metabolic mechanisms that could underly both severe acute COVID-19 and post-acute sequelae of CoV-2, and then consider how these might be targeted for future therapeutic approaches.
[eLife] |
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| The authors compare the fundamental differences between alveolar macrophages and circulating monocyte-derived macrophages in the context of tuberculosis and summarize the recent advances in elucidating the epigenomes of these cells.
[Infection and Immunity] |
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| One lesson is to only trust the most rigorous studies, known as randomized controlled clinical trials. But an equally important one: We need to get much better at conducting these rigorous studies more quickly and cheaply — and that goes beyond the COVID pandemic.
[STAT News] |
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| Adding to the brutal, immediate effects of Russia’s invasion, the Ukrainian people are facing an onslaught of infectious diseases. Some threats — such as the spread of COVID-19 — are immediate, as people huddle in basements, subway stations and temporary shelters to protect themselves from bombardments.
[NatureNews] |
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| April 27, 2022
Riviera Maya, Mexico |
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| | Harvard University – Boston, Massachusetts, United States |
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| | Gilead Sciences – Foster City, California, United States |
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| | Hans-Kn̦ll-Institute РJena, Germany |
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| | Cedars Sinai – Los Angeles, California, United States |
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| | Hong Kong University – Hong Kong, China |
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