 | | Vol. 10.12 – 30 March, 2022 |
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| Researchers used single-cell ECCITE-seq cellular transcriptome, HIV-1 RNA, and TCR sequences within the same single cell to track clonal expansion dynamics in longitudinally archived samples from six HIV-1-infected individuals and two uninfected individuals.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers characterized the functional SARS-CoV-2 T cell responses in severe versus recovered, mild COVID-19 patients to determine whether differences were detectable.
[American Journal of Respiratory and Critical Care Medicine] |
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| The authors obtained the extended conformation of the native monomer of SARS-CoV-2 main protease by trapping it with nanobodies, and found that the catalytic domain and the helix domain dissociated, revealing allosteric targets.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Pulmonary viral burden was reduced by anti-SARS-CoV-2 antibody treatment, and similar or increased by dexamethasone alone. Dexamethasone exhibited strong anti-inflammatory effects and prevented fulminant disease in a severe disease model.
[Molecular Therapy] |
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| Scientists showed that octogenarians, a high-risk population, mount a sustained SARS-CoV-2 spike-specific IgG antibody response for 15 months following infection.
[Cell Reports] |
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| In both model systems, Mycobacterium tuberculosis (Mtb)-infected mice were resistant to the pathological consequences of secondary SARS-CoV-2 infection, and SARS-CoV-2 infection did not affect Mtb burdens.
[PLoS Pathogens] |
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| Investigators showed that self-amplifying mRNA SARS-CoV-2 vaccines raised potent neutralizing antibody responses in mice against not only the original virus but also the alpha, beta, gamma, and delta variants.
[Molecular Therapy-Methods & Clinical Development] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists tested persons for anti-HBs levels 35 years after receiving the primary series. Those with levels under 10 mIU/ml received one booster dose of recombinant hepatitis B vaccine two-four weeks later and were then evaluated on the basis of anti-HBs measurements 30 days post-booster.
[Hepatology] |
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| Investigators reported that caspase-8 was a central regulator of regulatory T cell homeostasis in a context-specific manner that was decisive during immune responses.
[Science Immunology] |
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| The authors reported that vaccinia C7 was a crucial virulence factor that blocked activation of the transcription factor IRF3.
[Nature Communications] |
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| Investigators observed that the protection against influenza A virus after active vaccination with matrix protein 2 ectodomain viral antigen was lost was in Ripk3−/− mice.
[Cell Death & Disease] |
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| HPV16 avidity among women who were HPV16-seropositive women at HPV vaccination, a marker of natural immune response to HPV16 infection, was significantly lower than those of HPV16-seronegative women, a difference that was more pronounced among one-dose recipients.
[NPJ Vaccines] |
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| Scientists showed that, in comparison with a pre-epidemic isolate infection of Zika virus (ZIKV), CD4 T cells were less polarized to the Th1 subtype following Brazilian ZIKV isolate challenge in mice.
[Journal of Immunology] |
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| In vitro activated platelets inhibited Bacillus Calmette-Guerin-induced T lymphocyte proliferation and IFN-γ production.
[European Journal of Immunology] |
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| Researchers reported the isolation of 3H4, a murine human leukocyte antigen E (HLA-E)-VL9-specific IgM antibody that enhanced killing of HLA-E-VL9-expressing cells by an NKG2A+ NK cell line.
[Communications Biology] |
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| Based on evidence from the literature, as well as international scientific recommendations, the authors review the relationships between COVID-19, autoimmunity and patients with autoimmune rheumatic and musculoskeletal disease.
[Molecular Medicine] |
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| On 1 April 2022, Japan’s health ministry will resume recommending that girls ages 12 to 16 get vaccinated against human papillomavirus (HPV)—“an important signal of confidence in the vaccine and its safety,” says Paul Bloem, HPV vaccine strategy lead at the World Health Organization.
[ScienceInsider] |
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First Wave BioPharma, Inc. announced the continued enhancement of the intellectual property portfolio governing niclosamide as a treatment for COVID-19-related gastrointestinal infections.
[First Wave BioPharma, Inc.] |
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| April 8 – 13, 2022
New Orleans, Louisiana, United States |
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| | The Wellcome Trust – London, England, United Kingdom |
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| | University of Toronto – Toronto, Ontario, Canada |
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| | Harvard University – Boston, Massachusetts, United States |
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| | Gilead Sciences – Foster City, California, United States |
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| | Hans-Knöll-Institute – Jena, Germany |
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