 | | Vol. 10.14 – 13 April, 2022 |
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| Investigators examined antibody and memory B cell responses longitudinally for nine to ten months after primary two-dose
SARS-CoV-2 mRNA vaccination and three months after a third dose.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using national COVID-19 notification, hospitalization, and vaccination datasets from Brazil, researchers did a
test-negative, case-control study to assess the effectiveness of four vaccines for individuals with laboratory-confirmed previous SARS-CoV-2 infection.
[Lancet Infectious Diseases] |
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| Scientists assessed affinity and neutralization potency against the Omicron variant of several hundred naturally expressed
memory B cell-derived monoclonal IgG antibodies from vaccinated COVID-19-recovered and -naïve individuals.
[Immunity] |
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| The authors used a cell-free expression workflow to rapidly screen and optimize constructs containing multiple
computationally designed miniprotein inhibitors of SARS-CoV-2.
[Science Translational Medicine] |
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| Investigators presented a systematic, comparative evaluation of various biologically derived nanoscale vesicles, which may
be particularly well suited to sustained or repeated administration in the clinic due to low toxicity, and investigated their potential to inhibit multiple classes of model SARS-CoV-2 virions.
[Small] |
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| Researchers performed a multidimensional assessment evaluating various parameters, including pulmonary function tests and
cardiopulmonary exercise testing, and implemented multivariable logistic regression to assess risk factors for significant long COVID fatigue.
[Clinical infectious Diseases] |
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| Scientists reconstituted an in vitro pseudovirus-liposome fusion reaction and reported that SARS-CoV-2 wild-type
spike was a dynamic Ca2+ sensor, and D614G mutation enhanced dynamic calcium sensitivity of spike protein for facilitating membrane fusion.
[Cell Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors presented receptor-antigen pairing by targeted retroviruses, which combined viral pseudotyping and molecular
engineering approaches to enable one-pot library-on-library interaction screens by displaying antigens on the surface of lentiviruses and encoding their identity in the viral genome.
[Nature Methods] |
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| Investigators combined in situ metabolic imaging and transcriptional analyses to demonstrate that Klebsiella
pneumoniae sequence type 258 activated host glutaminolysis and fatty acid oxidation.
[Cell Metabolism] |
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| Hypothyroid mice displayed increased survival after infection with Plasmodium berghei ANKA, diminishing
intracranial pressure and brain damage, without altering pathogen burden, blood-brain barrier disruption, or immune cell infiltration.
[Science Advances] |
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| Scientists probed the full influenza virus genome by next-generation sequencing directly ex vivo from infected
mice, in the context of an experimental T cell-based vaccine, an H5N1-based viral vectored vaccinia vaccine Wyeth/IL-15/5Flu, versus the current standard-of-care.
[Science Advances] |
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| Researchers used a human lung alveolus chip that experienced cyclic breathing-like deformations to investigate whether
physical forces influenced innate immune responses to viral infection.
[Nature Communications] |
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| Investigators performed comprehensive immune profiling of the humoral response to HIV-1 in long-term post-treatment
controllers.
[Nature Communications] |
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| Scientists provided a molecular analysis of chlamydial apoptosis-inhibition in infected human cells and demonstrate that
the block of apoptosis occurs during the activation of the effectors of mitochondrial apoptosis, Bak and Bax.
[Cell Death & Differentiation] |
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| Using microbiological, live microscopy and microfluidics analyses, the authors demonstrated that plasmids could persist
for multiple generations in some Escherichia coli cell lineages at conditions of continuous targeting by the type I-E CRISPR-Cas system.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers studied how bacterial growth dynamics could overcome differences in antibiotic susceptibility in determining
community resilience: the recovery of the original community state following antibiotic exposure.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors share lessons learned over a decade of nanomedicine research and discuss the current knowledge about several
factors that individually or collectively contribute to infusion reactions to nanomedicines.
[Nature Nanotechnology] |
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| Scientists evaluate current diagnostic assays endorsed by the World Health Organization and identify the gaps between
existing conventional tests and the ideal point-of-care test for tuberculosis disease.
[Science Translational Medicine] |
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| Investigators discuss a proposed interaction between SARS-CoV-2 and toll-like receptor 2 (TLR2) in the central nervous
system.
[Experimental and Molecular Medicine] |
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| MediciNova, Inc. announced that the Phase II clinical trial of MN-166 in hospitalized COVID-19 patients at risk for
developing acute respiratory distress syndrome has completed enrollment.
[MediciNova, Inc.] |
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| Cocrystal Pharma, Inc. reported preliminary results of a Phase I study with CC-42344, a broad-spectrum oral antiviral for
the treatment of pandemic and seasonal influenza A, demonstrating a favorable safety and pharmacokinetic profile.
[Cocrystal Pharma, Inc.] |
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| SyneuRx™ International announced it has completed enrollment for its Phase II clinical trial evaluating the
efficacy and safety of SNB01 (‘Pentarlandir’), a novel COVID-19 oral antiviral candidate.
[SyneuRx™ International] |
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| Scientists in more than 20 countries have started to gather data for the largest ever vaccine safety project. Members of
the effort, called the Global Vaccine Data Network, fruitlessly sought funding after conceiving the project more than ten years ago.
[ScienceInsider] |
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| May 22 – 25, 2022
Denver, Colorado, United States |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | University of Kentucky – Lexington, Kentucky, United States |
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| | Aarhus University – Aarhus, Denmark |
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