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| Neutralization experiments revealed that immunity induced by COVID vaccines widely administered to human populations was not effective against the SARS-CoV-2 Omicron lineage, BA.2, similar to BA.1, and that the antigenicity of BA.2 was notably different from that of BA.1.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| To better understand factors that promoted or prevented remdesivir (RDV) resistance, the authors passaged SARS-CoV-2 in the presence of increasing concentrations of GS-441524, the parent nucleoside of RDV.
[Science Translational Medicine] |
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| Investigators captured the dynamics of infectious virus and viral RNA shedding during acute SARS-CoV-2 infection through daily longitudinal sampling of 60 individuals for up to 14 days.
[Nature Microbiology] |
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| By performing in-depth comparisons of the SARS-CoV-2-specific T cell epitope repertoire after infection and messenger RNA vaccination, scientists demonstrated that spike-derived epitopes were not dominantly targeted in convalescent individuals compared to non-spike epitopes.
[Nature Microbiology] |
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| The authors developed a panel of broadly neutralizing antibodies against Omicron and other variants of concern elicited by vaccination of adenovirus-vectored COVID-19 vaccine.
[Signal Transduction and Targeted Therapy] |
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| Scientists presented MEDi, a novel mammalian epitope display that allowed an unbiased, affordable, high-resolution mapping of MHC peptide presentation capacity.
[Science Advances] |
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| Researchers showed that poor glycaemic control, assessed as mean HbA1c in the post-vaccination period, was associated with lower immune responses and an increased incidence of SARS-CoV-2 breakthrough infections in type 2 diabetes patients vaccinated with mRNA-BNT162b2.
[Nature Communications] |
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| Investigators utilized mass spectrometry proteomics to determine the plasma proteins expressed in healthy children pre-pandemic, children with multisystem inflammatory syndrome and children with COVID-19 induced acute respiratory distress syndrome (ARDS).
[Nature Communications] |
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| The authors identified a unique memory-like NK cell subset that accumulated with aging and correlated with disease severity in COVID-19.
[Genome Medicine] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers identified correlates of bacterial control in cynomolgus macaque lung granulomas by co-registering longitudinal positron emission tomography and computed tomography imaging, single-cell RNA sequencing, and measures of bacterial clearance.
[Immunity] |
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| Following subcutaneous bacterial infection, adipocytes surrounding draining lymph nodes initiated a transcriptional response indicative of stimulation with IFN-γ and a shift away from lipid metabolism toward an immunologic function.
[Cell Metabolism] |
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| The authors used 3344 sequences from 23 countries to show that, on average, there are 28.1 transmission chains of Bordetella pertussis circulating within a subnational region, with the number of chains strongly associated with host population size.
[Science Translational Medicine] |
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| Researchers compared >160,000 human T cell leukemia virus type 1 (HTLV-1) integration sites from T cells isolated ex vivo from naturally infected individuals with >230,000 HTLV-1 integration sites from in vitro infection to identify genomic features that determined selective clonal survival.
[Science Advances] |
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| Scientists demonstrated that brush cell signaling stimulated adjacent sensory nerve endings in the trachea to release the neuropeptides CGRP and Substance P that mediated plasma extravasation, neutrophil recruitment and diapedesis.
[Journal of Clinical Investigation] |
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| Using a genome-wide CRISPR knockout screen, investigators identified placenta-associated 8 protein (PLAC8) as an essential host factor for swine acute diarrhea syndrome coronavirus (SADS-CoV) infection.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers provided experimental evidence that cell envelope stress represented an important feature of surface sensing in P. aeruginosa.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors discuss the role of vaccine-induced T cells in two distinct stages of infection: firstly, in protection from acquisition of symptomatic SARS-CoV-2 infection following exposure; secondly, if infection does occur, the potential for T cells to reduce the risk of developing severe COVID-19.
[Nature Reviews Immunology] |
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| Large-scale genetic association studies, encompassing both rare and common genetic variants, have used different study designs and multiple disease phenotype definitions to identify several genomic regions associated with COVID-19.
[Nature Reviews Genetics] |
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| Scientists assess the safety and efficacy of COVID-19 vaccines, including the possible complications and different effects on pregnant women, the elderly, people with immune diseases and AIDS, transplant recipients, and cancer patients.
[Signal Transduction and Targeted Therapy] |
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| RightEye has signed a research collaboration agreement with the Massachusetts Institute of Technology (MIT) to study an oculomotor “signature” for Lyme disease.
[RightEye] |
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| AB Science SA announced the continuation of the Phase II study evaluating masitinib in combination with isoquercetin in COVID-19, following the recommendation of the DSMB.
[AB Science SA] |
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| Biomerica, Inc. announced it has submitted a 510(k) premarket notification to the US FDA for hp+detect™, a new product that detects the presence of the H. pylori bacteria, which infects approximately 35% of the US population.
[Biomerica, Inc.] |
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| A person has tested positive for avian influenza A(H5) virus in the US, as reported by Colorado and confirmed by the Center for Disease Control. This case occurred in a person who had direct exposure to poultry and was involved in the culling of poultry with presumptive H5N1 bird flu.
[Center for Disease Control] |
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| In February, the Central Drugs Standard Control Organization had authorized the use of Corbevax for adolescents ages 12 to 18. But within weeks, it was revealed that the National Technical Advisory Group on Immunisation had questioned whether Biological E had shown the vaccine is effective.
[Science Insider] |
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| June 15 – 18, 2022
San Francisco, California, United States |
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| | Ragon Institute of MGH, MIT and Harvard – Cambridge, Massachusetts, United States |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | The Pirbright Institute – Pirbright, England, United Kingdom |
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| | New York University College of Dentistry – New York, New York, United States |
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| | Uppsala University – Uppsala, Sweden |
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