Selective Clonal Persistence of Human Retroviruses In Vivo: Radial Chromatin Organization, Integration Site, and Host Transcription

Researchers compared >160,000 human T cell leukemia virus type 1 (HTLV-1) integration sites from T cells isolated ex vivo from naturally infected individuals with >230,000 HTLV-1 integration sites from in vitro infection to identify genomic features that determined selective clonal survival.