 | | Vol. 10.28 – 20 July, 2022 |
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| Researchers showed that the large number of Omicron sublineage spike mutations led to enhanced ACE2 binding, reduced fusogenicity, and severe dampening of plasma neutralizing activity elicited by infection or seven clinical vaccines relative to the ancestral virus.
[Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists assessed the single-cell profile of SARS-CoV-2-specific T cells post-mRNA vaccination in healthy individuals and patients with various forms of immunodeficiencies.
[Immunity] |
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| Investigators found that a two-dose SARS-CoV-2 vaccinated group had similar peak viral titers and comparable speeds of viral RNA clearance to a non-vaccinated group but accelerated viral suppression in the middle course of the disease.
[Nature Communications] |
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| The authors developed prototype lipid nanoparticle (LNP)-mRNA vaccine candidates against SARS-CoV-2 Delta, SARS-CoV, and middle east
9 respiratory syndrome coronavirus, and tested how multiplexing LNP-mRNAs could induce effective immune responses in animal models.
[Cell Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists showed that pulmonary infection with Murid herpesvirus 4, a mouse γHV, drove the recruitment of Ly6Chi monocytes into the airway, thereby modulating the host immune response.
[Science Immunology] |
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| Researchers showed that glucuronoxylomannan, the major polysaccharide component of C. neoformans, induced the recruitment of neutrophilic myeloid-derived suppressor cells in mice and patients with cryptococcosis.
[Nature Communications] |
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| Investigators demonstrated that high-risk human papillomaviruses hijacked a natural function of apoptotic caspases to suppress an IFN response in differentiating epithelial cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists used the simian immunodeficiency virus mac239 strain to infect six young and six old Chinese rhesus macaques and compared the infection characteristics of the two groups in the chronic stage through multiplex immunofluorescence staining of lymph nodes.
[Cellular & Molecular Immunology] |
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| Vaccination of cynomolgus monkeys with a recombinant vesicular stomatitis virus vector expressing the glycoprotein precursor of LASV lineage IV strain Josiah induced fast-acting protection in monkeys challenged three or seven days later with a genetically heterologous lineage II isolate of LASV from Nigeria.
[Cell Reports] |
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| The authors performed in vivo RNA-sequencing analysis of Staphylococcus aureus in infected mouse liver and compared the transcriptome of S. aureus at 6, 24, and 48 hours post-infection in mice and in culture medium.
[Communications Biology] |
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| Scientists investigated the hypothesis that herpes simplex virus-1, through Us11, could recruit caspase-8, a key enzyme regulating programmed cell death.
[Scientific Reports] |
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| Researchers demonstrated a number of innate and adaptive response differences between Bacillus Calmette-Guérin (BCG)- and BCGΔBCG1419c-immunized mice which were consistent with the latter being longer lasting and potentially less inflammatory.
[Scientific Reports] |
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| The authors performed a longitudinal analysis of immune responses following immunization with the modified vaccinia virus Ankara (MVA)-based vaccine MVA-Middle East respiratory syndrome (MERS)-S encoding the MERS-CoV-spike protein.
[Cell Reports Medicine] |
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| Investigators propose that alveolar macrophages (AMs) are the Achilles’ heel of SARS-CoV-2 infection and that modulation of the endosomal pH of AMs has the potential to eliminate invaded SARS-CoV-2; the same strategy might also be suitable for other lethal respiratory viruses.
[Signal Transduction and Targeted Therapy] |
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| Scientists focus on the origin, virological features, immune evasion, and intervention of Omicron sublineages, which will benefit the development of next-generation vaccines and therapeutics, including pan-sarbecovirus and universal anti-CoV therapeutics.
[Signal Transduction and Targeted Therapy] |
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| The authors describe infections in recipients of chimeric antigen receptor T cells, and discuss risk factors and potential mitigation strategies.
[Bone Marrow Transplantation] |
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| John Nkengasong, 58, has been appointed the first African-born head of the US President’s Emergency Plan for AIDS Relief, a program that helps more than 50 countries respond to their HIV/AIDS epidemics.
[ScienceInsider] |
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| A shift is afoot in the search for COVID-19 therapies: some researchers are turning their attention towards drugs that could be used to treat mild illness, even in people who are not at high risk of severe disease.
[Nature News] |
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| August 7 – 12, 2022
Steamboat Springs, Colorado, United States |
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| | University of British Columbia – Vancouver, British Columbia, Canada |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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| | Boehringer Ingelheim – Vienna, Austria |
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| | The Pirbright Institute – Surrey, England, United Kingdom |
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| | Georgia Institute of Technology – Atlanta, Georgia, United States |
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