Inhibition of Myeloid-Derived Suppressor Cell Arginase-1 Production Enhances T-Cell-Based Immunotherapy against Cryptococcus neoformans Infection

Researchers showed that glucuronoxylomannan, the major polysaccharide component of C. neoformans, induced the recruitment of neutrophilic myeloid-derived suppressor cells in mice and patients with cryptococcosis.