 | | Vol. 10.30 – 3 August, 2022 |
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| Researchers suggested a pivotal role for gasdermin D as an executer of multiple cell death pathways and demonstrated that mitochondrial dysfunction could direct immune outcomes via cell death modality switching.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors deeply profiled the vaccine-induced humoral immune response in 6 to 11 year old children receiving either a pediatric or adult dose of the mRNA-1273 vaccine and compared these responses to vaccinated adults, infected children, and children that experienced multisystem inflammatory syndrome in children.
[Science Translational Medicine] |
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| Scientists showed that serum concentrations of apolipoprotein E (APOE) correlated inversely with levels of cytokine/chemokine in 73 COVID-19 patients.
[Signal Transduction and Targeted Therapy] |
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| To investigate the potential for vaccine-associated enhanced respiratory disease induction in COVID-19, the authors evaluated two vaccine leads utilizing a severe hamster infection model: a TH1-biased measles vaccine-derived candidate and a TH2-biased alum-adjuvanted, non-stabilized Spike protein.
[Cell Reports] |
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| Investigators used primary nasal epithelial cells (NECs) from children and adults, differentiated at an air–liquid interface to show that the ancestral SARS-CoV-2 replicated to significantly lower titers in the NECs of children compared to those of adults.
[PLoS Biology] |
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| Intramuscular immunization was enhanced by trans-complementation of the vesicular stomatitis virus (VSV)-vectored vaccines by the VSV glycoprotein and led to protection from COVID-19, although not achieving sterilizing immunity.
[NPJ Vaccines] |
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| Researchers developed and characterized a novel mRNA vaccine encoding the HA antigen of influenza A virus, termed ARIAV. Then, ARIAV was combined with their COVID-19 mRNA vaccine ARCoV, which encoded the receptor-binding domain of the SARS-CoV-2 S protein, to formulate the final combined vaccine, AR-CoV/IAV.
[NPJ Vaccines] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | Scientists examined the impact of anti-PD-1 immunotherapy on the helper CD4 T cells (Tfh)–B cell axis responding to unrelated viral antigens.
[Nature Immunology] |
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| The authors identified several genes reproducibly associated with progression to infection in patients colonized by diverse Klebsiella.
[Nature Communications] |
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| Investigators showed application of cationic adjuvant formulation CAF08, a liposomal vaccine formulation tailored to induce Th 1 immunity in early life via synergistic engagement of Toll-like Receptor 7/8 and the C-type lectin receptor Mincle.
[Nature Communications] |
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| The authors unraveled the previously un-appreciated role of facilitates chromatin transcription (FACT) complex in coordinating with BRD4 and regulating interferon signaling in both epithelial and NK cells, and also proposed the novel application of the FACT inhibitor CBL0137 to treat viral infections.
[Nucleic Acids Research] |
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| Scientists isolated two Epstein-Barr virus (EBV) glycoprotein B (gB)-specific neutralizing antibodies, 3A3 and 3A5; both effectively neutralized the dual-tropic EBV infection of B and epithelial cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that lymphatic vessel occlusion substantially reduced neutrophil recruitment to the lymph node (LN). Lymphatic vessels effectively transported bacteria and proinflammatory chemokines to the LN.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists describe a genome-wide screen of Plasmodium kinesins, revealing diverse subcellular locations and functions in spindle assembly, axoneme formation, and cell morphology.
[PLoS Biology] |
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| Investigators discuss recent advances pertaining to antiviral delivery and inhibitory effects of nanosponges against SARS-CoV-2, focusing on important challenges and opportunities.
[Drug Discovery Today] |
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| The authors provide an overview of the inflammatory pathway that underlies HIV-1 infection, explicitly highlighting the role of the NLRP3 inflammasome.
[Translational Research] |
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| There is growing interest in exploring how archived drug resistance-associated mutations modulate antiretroviral treatment outcomes and therefore how the sequencing of cellular HIV DNA may aid treatment decisions.
[Infectious Diseases and Therapy] |
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| Sunshine Biopharma, Inc. announced that it has agreed to provide additional resources to the University of Arizona R. Ken Coit College of Pharmacy for the purposes of accelerating the development of novel PLpro inhibitors currently underway.
[Sunshine Biopharma, Inc.] |
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| Pfizer, Inc. and BioNTech SE announced that the companies have initiated a randomized, active-controlled, observer-blind, Phase II study to evaluate the safety, tolerability, and immune response of an enhanced COVID-19 mRNA-based vaccine candidate at a 30 µg dose level.
[Pfizer, Inc.] |
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| The world’s response to the five-decade-old HIV/AIDS pandemic is faltering badly in the face of declines in spending and the COVID-19 pandemic, according to annual update from the Joint United Programme on HIV/AIDS.
[ScienceInsider] |
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| August 28 – September 2, 2022
Asheville, North Carolina, United States |
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| | King’s College London – London, United Kingdom |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | Gilead Sciences, Inc. – Foster City, California, United States |
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| | Wellcome Sanger Institute – Cambridge, England, United Kingdom |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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