 | | Vol. 10.33 – 25 August, 2022 |
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| CD8+ T cells responding to Listeria infection preferentially consumed lactate over glucose as a TCA cycle substrate in vitro, with lactate enhancing T cell bioenergetic and biosynthetic capacity.
[Cell Metabolism] |
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| PUBLICATIONSRanked by the impact factor of the journal |
| | | Investigators used an antiviral lipopeptide entry inhibitor to arrest S protein refolding and thereby capture intermediates as S proteins interacted with hACE2 and fusion-activating proteases on cell-derived target membranes.
[Science Advances] |
| | Scientists successfully generated a panel of SARS-CoV-2/SARS-CoV cross-neutralizing antibodies by sequential immunization of the two pseudoviruses.
[Proceedings of the National Academy of Sciences of the United States of America] |
| | Researchers elucidated the developmental process and maturation pathway of P2C-1F11, providing some important information for the design of novel immunogens to elicit more potent neutralizing antibodies against SARS-CoV-2 infection.
[Cell Reports] |
| | Investigators demonstrated that hepatocytes were susceptible to infection in different models: primary hepatocytes derived from humanized angiotensin-converting enzyme-2 mice and primary human hepatocytes.
[Communications Biology] |
| | Scientists identified three phenolic compounds bound to SARS-CoV-2 papain-like protease, preventing essential molecular interactions to interferon-stimulated gene 15 by screening a natural compound library.
[Communications Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| V. vulnificus infection at the sub-hemolytic level induced shape change of human red blood cells (RBCs) accompanied by phosphatidylserine exposure, and microvesicle generation, leading to the procoagulant activation of RBCs and ultimately, acquisition of prothrombotic activity.
[Nature Communications] |
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| Researchers analyzed the impact of eight patient-derived open reading frame 2 (ORF2) single-nucleotide variants, which occurred under Ribavirin treatment, on the replication cycle and pathogenesis of Hepatitis E virus.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors discovered that intrinsically disordered HIV-1 core proteins condensed with the viral genomic RNA to assemble as biomolecular condensates attaining a geometry characteristic of viral reverse transcription complexes.
[Cell Reports] |
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| Scientists identified an immunization regimen that provided similar vaccine efficacy against controlled human malaria infection with homologous and heterologous Plasmodium falciparum (Pf) for at least nine weeks in malaria-naïve adults.
[NPJ Vaccines] |
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| Circular RNAs’ biogenesis, function, and their biomarker and therapeutic potential as well as their prospective application as a vaccine against viral infections such as COVID-19 are explained.
[Molecular Therapy-Nucleic Acids] |
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| MediciNova, Inc. announced that it plans to participate in RECLAIM (Recovering from COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial), a grant-funded, multi-center, randomized, clinical trial to evaluate MN-166 and other therapies for the treatment of Long COVID, the lingering symptoms of COVID-19.
[MediciNova, Inc.] |
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| Each year, Baylor College of Medicine faculty are recognized for their outstanding published scientific contributions to clinical and basic science research over the past three years through the Michael E. DeBakey MD Award for Excellence in Research.
[Baylor College of Medicine] |
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| November 10 – November 12
LOCATION |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | NIH National Cancer Institute – Bethesda, Maryland, United States |
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| | Dalla Lana School of Public Health – Toronto, Ontario, Canada |
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| | Washington University in St. Louis – St. Louis, Missouri, United States |
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