 | | Vol. 10.37 – 21 September, 2022 |
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| Scientists developed a preclinical glycopeptide antibiotic, MCC5145, that had excellent potency against hundreds of isolates of methicillin-resistant S. aureus and other Gram-positive bacteria, with a greater than 1000-fold margin over mammalian cell cytotoxicity values.
[Science Translational Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that wild-type/Wuhan variant S1 promoted neutrophil and macrophage recruitment, local and systemic hyperinflammation, emergency myelopoiesis, and hemorrhages.
[Science Advances] |
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| Researchers showed that scFv76 neutralized infectivity and fusogenic activity of Omicron BA.1 and BA.2 variants. Cryo-EM analysis revealed that scFv76 bound to a well-conserved SARS-CoV-2 spike epitope, providing the structural basis for its broad-spectrum activity.
[Molecular Therapy] |
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| Scientists used human induced pluripotent stem cell-derived liver organoids to recapitulate and characterize liver pathology following virus exposure.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors performed a high-throughput screening using a 2560 small-molecule compound library and identified FDA-approved drugs that functioned as pan-inflammasome inhibitors.
[Science Advances] |
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| Investigators archived sera and mononuclear cells that were prospectively collected up to 18 years after cure of chronic hepatitis C virus (HCV) infection to determine the role of HCV antigen in maintaining neutralizing antibody and B cell responses.
[Nature Communications] |
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| Investigators developed a genomics profiling method that enabled discrete analysis of Zika virus (ZIKV)-infected versus neighboring, uninfected primary human dendritic cells to increase the sensitivity and specificity with which ZIKV-modulated pathways can be identified.
[Nature Communications] |
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| The authors showed that Bcl10 was involved in type I interferon expression in response to DNA virus infection and that Bcl10-deficient mice were more susceptible to Herpes simplex virus 1 infection than control mice.
[Science China Life Sciences] |
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| As compared to in vitro differentiated monocyte derived macrophages, alveolar macrophages from normal donors had sixfold lower levels of dTTP and a sixfold increased dUTP/dTTP, indicating a highly restrictive dNTP pool for reverse transcription.
[Retrovirology] |
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| Scientists enrolled 13 patients living with HIV who had been receiving antiretroviral therapy (ART) for five years. They measured levels of serum globulin, cell-associated HIV DNA and RNA, and p24 antibody at zero, one, three, and five years of ART.
[HIV Medicine] |
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| Researchers explored the changes in the frequencies, activation/exhaustion phenotypes, and function of CD8+ T cells from early-treated people living with HIV receiving cART in a one-year follow-up, using a multidimensional flow cytometry approach.
[Aids Research and Therapy] |
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| Recently, several molecular studies uncovered RNF213 as a key antimicrobial protein with important functions in the immune system. In addition, an increasing number of clinical reports describe the development of moyamoya angiopathy associated with infection or autoimmune disorders.
[Trends in Molecular Medicine] |
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| Pardes Biosciences, Inc. commencemened a Phase II double-blind, randomized study to evaluate the antiviral activity, safety, and efficacy of orally administered PBI-0451 compared with placebo in non-hospitalized symptomatic adults with COVID-19 who are not at increased risk of progressing to severe illness.
[Pardes Biosciences, Inc.] |
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| The Alberta Conservation Association, in partnership with Alberta Environment and Parks has provided $1.2 million to fund research on an oral vaccine to manage chronic wasting disease, which poses significant risk to wild populations in four provinces and 28 states.
[University of Saskatchewan] |
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| October 9 – 13, 2022
Cairns, Australia |
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| | University of St Andrews – St Andrews, Scotland, United Kingdom |
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| | University of Wisconsin-Madison – Madison, Wisconsin, United States |
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| | CRUK Beatson Institute for Cancer Research – Glasgow, United Kingdom |
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| | Netherlands Cancer Institute (AVL) – Amsterdam, Netherlands |
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| | Louisiana State University – Baton Rouge, Louisiana, United States |
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Cancer Stem Cell News
Cell Therapy News
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