 | | Vol. 10.41 – 26 October, 2022 |
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| The authors generated a single-cell multiomic atlas of T cell exhaustion in murine chronic viral infection that redefined exhausted T cell phenotypic diversity, including two late-stage Tex subsets with either a terminal exhaustion or a killer cell lectin-like receptor-expressing cytotoxic phenotype.
[Nature Immunology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Genetic analysis revealed that multisystem inflammatory syndrome in children patients were enriched in rare deleterious variants impacting inflammation and autoimmunity pathways, including dominant-negative mutations in the Notch1 regulators NUMB and NUMBL leading to Notch1 upregulation.
[Journal of Clinical Investigation] |
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| Monocyte frequency and count were increased in peripheral blood up to three months post vaccination compared with their own pre-vaccine control. Expression of HLA-DR, CD40 and CD80 was enhanced on monocytes for up to three months following vaccination.
[Journal of Clinical Investigation] |
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| Scientists reported that treatment-emergent resistance mutations were significantly more likely to be detected after bamlanivimab 700 mg treatment compared with the placebo group.
[Nature Microbiology] |
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| The authors examined the effects of peripheral oxygen saturation and peak body temperature during acute infection on immune, oxidative and nitrosative stress pathways and neuropsychiatric symptoms of Long COVID.
[Molecular Psychiatry] |
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| In this multicentre, randomised, double-blind, placebo-controlled trial, 304 hospitalised patients with COVID-19 pneumonia were randomised to receive 1g of methylprednisolone intravenously for three consecutive days or placebo in addition to standard dexamethasone.
[European Respiratory Journal] |
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| Scientists found the receptor-binding domain-sortase A-conjugated ferritin nanoparticle induced neutralizing antibodies in non-human primate against pseudoviruses of SARS-CoV and SARS-CoV-2 variants including 614G, Beta, Delta, Omicron BA.1, BA.2, BA.2.12.1, and BA.4/BA.5, and a designed variant with escape mutations, PMS20.
[Nature Communications] |
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| Reearchers evaluated the characteristics of SARS-CoV-2 reinfection and persistent RNA detection using independent genomic, clinical, and laboratory assessments.
[Clinical infectious Diseases] |
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| Researchers reported a ZBP1-induced inflammatory signaling pathway mediated by K63- and M1-linked ubiquitin chains, which depended on RIPK1 and RIPK3 as scaffolds independently of cell death.
[EMBO Reports] |
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| Investigators used known substrate specificities of mammalian protein kinases to deconvolute the sequence of phosphorylation events mediated by three host protein kinase families that coordinately phosphorylated a cluster of serine and threonine residues in the viral N protein, which is required for viral replication.
[Science Signaling] |
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| The authors assessed humoral and cellular immune responses against SARS-CoV-2 following recovery from infection, vaccine dose 1 and vaccine dose 2 in 35 persons recovered from COVID-19.
[NPJ Vaccines] |
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| Investigators showed that without previous history of COVID-19, BA.2 infection induced a reduced immune response against all variants of concern compared to BA.1 infection.
[iScience] |
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| To develop a live-attenuated vaccine, scientists generated a virus that combined all these temperature-sensitive-associated mutations, which showed a robust TS phenotype in vitro and high attenuation in vivo.
[iScience] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | The authors described an approach to systematically identify latency reversing agent combinations to reactivate latent HIV-1 using genome-wide CRISPR screens.
[Science Translational Medicine] |
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| Scientists identified the E3 ubiquitin ligase RNF115, which is enriched on phagosomes of IFN-γ activated macrophages, as an important regulator of phagosomal maturation.
[EMBO Journal] |
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| The authors described the isolation and characterization of a fully human monoclonal antibody for Hepatitis B Virus (HBV). This HuMab was isolated by a combinatorial screen of the memory B-cell repertoire from an acute/recovered HBV-infected patient.
[NPJ Vaccines] |
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| Serological analysis revealed a 23.66% and 27.23% seroprevalence of Q fever in cattle and buffalo, respectively. Odds ratio analysis of the factors associated with C. burnetii seropositivity was performed, and a multivariable logistic model identified five main variables associated with the seropositivity for coxiellosis.
[Scientific Reports] |
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| Investigators optimized the formulation delivery system, structure, and immunologic activity of novel small molecule imidazoquinoline TLR7/8 adjuvants towards human infant leukocytes, including dendritic cells.
[Scientific Reports] |
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| By using MGL2-DTR transgenic mice that encode human diphtheria toxin receptor in MGL2+ cells, scientists demonstrated the role of peritoneal peritoneal antigen presenting cells during F. hepatica infection in favoring parasite survival.
[Scientific Reports] |
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| Systemic metabolic sequelae such as insulin resistance and dyslipidaemia represent long-term health consequences of many infections such as human immunodeficiency virus, hepatitis C virus and SARS-CoV-2.
[Nature Metabolism] |
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| Scientists review the studies published since the emergence of the COVID-19 pandemic which utilize human pluripotent stem cells and their cardiovascular derivative cell types to interrogate the tropism and effects of SARS-CoV-2 infection in the heart, as well as explore potential therapies.
[Current Cardiology Reports] |
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| Vaccines, behavior change among the most affected group—men who have sex with men—and immunity after natural infection are all playing a role in that decline, said Erik Volz, an infectious disease modeler at Imperial College London.
[ScienceInsider] |
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| Controversy surrounding a study that involved modifying the SARS-CoV-2 virus has prompted researchers to call for better guidance from funders.
[Nature News] |
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| Now the pandemic is in its third year, and reports are circulating that the end of free-to-access COVID-19 research is nigh. If so, that would suggest publishers have decided that the COVID-19 emergency is over before world health authorities have. But is that the case?
[Nature News] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | National University of Singapore – Singapore, Singapore |
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| | Vancouver Infectious Diseases Centre – Vancouver, British Columbia, Canada |
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| | University of Florida – Gainesville, Florida, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | University of Alberta – Edmonton, Alberta, Canada |
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