 | | Vol. 10.42 – 2 November, 2022 |
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| The authors studied pathogen-specific adaptation within the innate immune system, tracking natural killer cell memory to human cytomegalovirus infection.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported on T cell immunity four weeks and six months after different vaccination regimens and four weeks after an additional booster vaccination, in comparison to SARS-CoV-2 T-cell responses in convalescents and prepandemic donors using interferon-gamma ELISpot assays and flow cytometry.
[Science Immunology] |
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| The hotspot interaction of viruses with receptor-derived short peptides was maximized by aptamer-like scaffolds, the compact and stable architectures of which could be in vitro selected from a myriad of the hotspot peptide-coupled random nucleic acids.
[Science Advances] |
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| Among 2,641 male and 244 female unvaccinated and seronegative recruits studied longitudinally, SARS-CoV-2 infections occurred in 1,033 males and 137 females.
[Cell Systems] |
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| The authors developed an easily-manufactured, potent self-amplifying RNA vaccine against SARS-CoV-2 that is stable at room temperature.
[NPJ Vaccines] |
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| Researchers evaluated the immune responses developed in SARS-CoV-2-uninfected patients with predominantly antibody-deficiencies after three mRNA-1273 vaccine doses.
[iScience] |
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| A549 cells were transduced to express ORF7a and ORF7b, respectively, to explore more in depth the role of each accessory protein in the pathological manifestation leading to COVID-19.
[iScience] |
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| Researchers analyzed an extended coagulation profile including biomarkers of endothelial damage in children with post covid condition and compared it with a control group of children that fully recovered post- SARS-CoV-2 infection.
[Scientific Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors integrated transcriptional data of over 3,000 samples, from 820 adults across 28 studies of 13 vaccines and analyzed vaccination-induced signatures of antibody responses.
[Nature Immunology] |
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| Investigators designed an anti-PDL1-IFNα heterodimeric fusion protein, in which one arm was derived from anti-PDL1 antibody and the other arm was IFNα, to allow targeted delivery of IFNα into the liver by anti-PDL1 antibody.
[Gut] |
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| Scientists showed that Mycobacterium tuberculosis infection remodeled lymph node architecture by increasing the number and paracortical translocation of B cells.
[Journal of Clinical Investigation] |
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| The authors tested the efficacy of TPOXX both in vitro and in vivo against a clade 2 Canadian 2022 isolate of monkeypox virus isolated during the current outbreak.
[Science Translational Medicine] |
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| Researchers demonstrated that epithelial cell–specific IκBζ-deficient (NfkbizΔK5) mice showed spontaneous skin inflammation with increased abundance of Staphylococcus aureus on the skin.
[Science Immunology] |
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| Scientists exposed the T cells to planar lipid bilayers containing ligands for T cell receptor and a T cell integrins and analyzed the cellular morphology, dynamics of synaptic interface formation and patterns of the cellular degranulation.
[Nature Communications] |
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| Researchers conducted a whole-genome CRISPR activation screen with influenza B virus (IBV). A top hit from their screen, beta-1,3-glucuronyltransferase 1, effectively blocked IBV infection.
[Nature Communications] |
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| While the ribotoxic stress response to UV and microbial molecules exclusively activated p38 through MAP3K ZAKα, infection with arthropod-borne alphaviruses, including Semliki Forest and Chikungunya virus, activated p38 through ZAKα and potentially other MAP3K.
[Journal of Experimental Medicine] |
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| Genetic ablation experiments identified that type I IFN drives exhaustion through an IRF7-dependent mechanism, possibly through an IFN-stimulated subset bridging progenitor and exhausted cells.
[Journal of Experimental Medicine] |
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| Investigators demonstrated the role of GM-CSF+ Tc17 cells for vaccine immunity against lethal fungal pneumonia and the cytokine requirements for their induction and memory homeostasis.
[Cell Reports] |
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| Protein levels and transcriptome of hemodialysis patients’ neutrophils indicated massive neutrophil degranulation with a dramatic reduction in reactive oxygen species production during an oxidative burst and defective oxidative cellular signaling.
[BMC Medicine] |
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| Frequencies of dengue purified inactivated vaccine-induced memory B cells specific to each DENV serotype remained high up to 12 months post-vaccination, and were higher in the dengue-primed than dengue-naive adults
[NPJ Vaccines] |
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| The emergence or re-emergence of orthopoxvirus in the human population can also occur in wild or domestic animals as intermediate hosts. More effective and safer vaccines for poxvirus can be developed by understanding how immunity is regulated in poxvirus and vaccines for DNA viruses.
[Cell Biology International] |
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| Ever since the Chinese city of Wuhan was identified as ground zero for the COVID-19 pandemic, a contingent of scientists have suspected that the virus could have leaked from one of the WIV’s complex of laboratories.
[Vanity Fair] |
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| The World Health Organization’s first ever fungal priority pathogens list highlights the growing threat of fungal diseases and antifungal resistance.
[The Scientist] |
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| Physicians who treat children who develop a strange polio-like syndrome known as acute flaccid myelitis had been steeling themselves this fall for an onslaught of cases of the irreversible condition, which appearred to be triggered by infection with an enterovirus known as EV-D68.
[STAT News] |
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| The current crop of immunity-dodging offshoots of the Omicron variant of SARS-CoV-2 is unprecedented in its diversity. This complexity makes it harder to predict coming waves of infection.
[Nature News] |
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| December 7 – 9, 2022
Geneva, Switzerland |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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| | Vancouver Infectious Diseases Centre – Vancouver, British Columbia, Canada |
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| | University of Florida – Gainesville, Florida, United States |
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