 | | Vol. 10.43 – 9 November, 2022 |
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| Investigators examined the role of tissue-resident meningeal macrophages (MM) in viral infection. MHC-II− MM were abundant neonatally, whereas MHC-II+ MM appeared over time.
[Immunity] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The receptor-binding domain spike protein–specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors.
[Journal of Experimental Medicine] |
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| 442 subjects received a third dose of BNT162b2. Vaccine-induced adverse events were captured up to seven days after vaccination.
[Clinical Cancer Research] |
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| To experimentally determine whether SARS-CoV-2 could replicate in and affect human brain cells, investigators infected iPSC-derived human brain organoids. They showed that SARS-CoV-2 could productively replicate and promote death of neural cells, including cortical neurons.
[PLoS Biology] |
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| Researchers compared the humoral and cellular immune responses of an extended course of recombinant receptor binding domain vaccine boosters with those from conventional immunization strategy in a Balb/c murine model.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators generated two mouse models, one to stably mark CD103+ T cells and the other to specifically deplete CD103− T cells.
[Science Immunology] |
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| Researchers investigated whether previously identified immune correlates of risk of tuberculosis (TB) disease also associate with increased risk of M.tb infection in BCG-vaccinated South African infants, who became infected with M.tb during 2-3 years of follow-up.
[Nature Communications] |
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| Scientists observed that frequencies of Pol- and Gag-specific CD8+ T cells, as well as Gag-induced interferon-γ responses, were significantly higher among individuals that received adjunctive 3BNC117 compared to ART-alone at 3 and 12 months after starting ART.
[Nature Communications] |
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| The authors reported three patients from two kindreds without EBV viremia or disease but with severe tuberculosis and inherited complete ITK deficiency, a condition associated with severe EBV disease that renders immunological studies challenging.
[Journal of Experimental Medicine] |
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| Researchers fabricated a multivalent influenza mRNA lipid nanoparticle vaccine with mRNAs of Hemagglutinins from influenza H1N1 and H3N2 viruses, Matrix protein 1, and Nucleoprotein.
[Molecular Therapy Nucleic Acids] |
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| Investigators demonstrated that the tegument protein UL21 in pseudorabies virus dampened type I interferon signaling by triggering the degradation of cyclic GMP-AMP synthase (CGAS) through the macroautophagy/autophagy-lysosome pathway.
[Autophagy] |
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| To provide insights into the mechanisms underlying the control of immune activation by changes in intestinal homeostasis, scientists conducted a forward genetic screen for suppressors of immune activation by intestinal distension in Caenorhabditis elegans.
[Cell Reports] |
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| Investigators demonstrated that interferon-λ acted directly on tuft cells to cure chronic MNoVCR6 infection and that type I and III IFNs signal together via STAT1 in tuft cells to restrict MNoVCW3 tropism.
[Cell Reports] |
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| Researchers investigated whether serum thrombospondin 2 was associated with clinicopathological features in hepatitis C virus-infected patients.
[Scientific Reports] |
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| The authors discuss innate immune sensing of mRNA vaccines at the cellular and intracellular levels and consider the contribution of both the mRNA and the lipid nanoparticle components to their immunogenicity.
[Immunity] |
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| New data from Pfizer and BioNTech on their bivalent COVID-19 vaccine suggests the updated product may be more protective against more recent Omicron subvariants than the original version of the vaccine, the companies said in a statement released November 4th, 2022.
[STAT News] |
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| More than one million lives might have been saved if COVID-19 vaccines had been shared more equitably with lower-income countries in 2021, according to mathematical models incorporating data from 152 countries.
[Nature News] |
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| A new vaccine against malaria showed promising preliminary results in a large trial in four African countries, boosting hopes that an additional tool may soon be available to help control the deadly disease.
[ScienceInsider] |
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| February 13 – 16, 2023
Breckenridge, Colorado, United States |
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| | St. Michael’s Hospital – Toronto, Ontario, Canada |
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| | Université Libre de Bruxelles – Gosselies, Belgium |
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| | Queen Mary University of London – London, England, United Kingdom |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | National University of Singapore – Singapore, Singapore |
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