 | | Vol. 10.45 – 23 November, 2022 |
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| Researchers identified the mechanisms that drive immune cell recruitment in the lung during viral respiratory infections and identified novel drug targets to reduce inflammation and disease severity.
[European Respiratory Journal] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that site-specific RNA endonuclease XNAzymes – artificial catalysts composed of single-stranded synthetic xeno-nucleic acid oligonucleotides – may be designed, synthesized and screened within days, enabling the discovery of a range of enzymes targeting SARS-CoV-2 ORF1ab, ORF7b, spike- and nucleocapsid-encoding RNA.
[Nature Communications] |
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| Using Danish nationwide registries, the authors obtained information on SARS-CoV-2 infections, COVID-19 vaccination, age, sex, comorbidity, staying at hospital, and country of origin.
[PLoS Medicine] |
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| Researchers collected saliva specimens from working-age adults receiving SARS-CoV-2 molecular testing at outpatient clinics and via mobile community-outreach testing between.
[Clinical infectious Diseases] |
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| Scientists described the features of patients presenting with new acute central nervous system demyelination resembling neuromyelitis optica spectrum disorders or myelin oligodendrocyte glycoprotein antibody–associated disease within eight weeks of SARS-CoV-2 vaccination.
[Neurology-Neuroimmunology & Neuroinflammation] |
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| The MANTICO trial was a non-inferiority randomized controlled trial comparing the clinical efficacy of early treatments with bamlanivimab/etesevimab, casirivimab/imdevimab, and sotrovimab in outpatients aged 50 or older with mild-to-moderate SARS-CoV-2 infection.
[eLife] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors showed virus-specific T cells were retained over one year in serial samples of rash site and contralateral unaffected skin of individuals recovered from zoster.
[Nature Communications] |
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| Scientists reported that tyrosyl-tRNA synthetase mimiced inflammatory stress inducing a unique megakaryocyte population with stem cell and myeloid markers through a mechanism dependent on Toll-like receptor activation and type I interferon signaling.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers investigated cell-associated-HIV-1 RNA transcripts in cells in cerebrospinal fluid and blood, using the highly sensitive Double-R assay, together with proton Magnetic Resonance Spectroscopy of major brain metabolites, in 16 people living with HIV-1 infection.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators showed that ileal expression of AGR2 correlated with mucosal Enterobactericeae abundance in human inflammatory bowel disease and that Agr2 deletion leads to ER-stress-dependent expansion of mucosal-associated adherent-invasive Escherichia coli.
[Cell Reports] |
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| Researchers used Olink proteomics to comprehensively analyze the aberrant inflammation-related proteins in chronic HIV-1-infected individuals, including in 24 treatment-naïve individuals, 33 immunological responders, and 38 immunological non-responders.
[Emerging Microbes & Infections] |
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| The authors created a nested case-control study within the Sabes study in Peru, and assessed a panel of plasma immune biomarkers at enrollment and longitudinally, including within a month of diagnosis of primary HIV or matched timepoint in controls.
[iScience] |
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Investigators explored the association between the expression of pyroptosis in peripheral blood and immune function reconstruction in HIV-1- infected patients.
[BMC Infectious Diseases] |
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| Chemotaxis drives pathogen colonization to sites of inflammation and injury and mediates fitness advantages through accessing host-derived nutrients from damaged tissue.
[Trends in Microbiology] |
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| The World Health Organization and the government of Uganda plan to test three candidate Ebola vaccines in a clinical trial during the ongoing outbreak in the East African nation, Director-General Tedros Adhanom Ghebreyesus announced Wednesday.
[STAT News] |
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| Takeda announced that the FDA has accepted and granted priority review of the Biologics License Application for TAK-003, the company’s investigational dengue vaccine candidate.
[Takeda] |
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| Hendra virus, like Nipah, SARS-CoV and SARS-CoV-2 is a bat virus that has spilled over into people. These viruses often reach humans through an intermediate animal, sometimes with deadly consequences.
[Nature News] |
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| February 15 – 17, 2023
Lorne, Victoria, Australia |
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| | Takeda – San Diego, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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| | University of Toronto Mississauga – Mississauga, Ontario, Canada |
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| | Icahn School of Medicine at Mount Sinai – New York, New York, United States |
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