 | | Vol. 10.46 – 30 November, 2022 |
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| Investigators systemically analyzed lung pathogenesis in SARS-CoV-2- and its delta variant-infected humanized CD147 transgenic mice. Histopathology and Transmission Electron Microscopy revealed inflammation, fibroblast expansion and pronounced fibrotic remodeling in SARS-CoV-2-infected lungs.
[Signal Transduction and Targeted Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors profiled binding of SARS-CoV-2 spike protein (S) against >9000 human proteins, and found an interaction between S and human estrogen receptor α (ERα). In cultured cells, S DNA transfection increased ERα cytoplasmic accumulation, and S treatment induced ER-dependent biological effects.
[Science Advances] |
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| Four months after infection, children showed an enhanced specific antibody response and lower but detectable spike 1 protein (S1)-specific B and T cell responses, compared to their parents. One year after infection, an increase in the S1-specific IgA class switched, and the expression of CD27 on S1-specific B cells and T cell maturation were observed.
[Nature Communications] |
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| DNA samples extracted from CD14+ CD15– monocytes of 48 severe COVID-19 patients and 11 healthy controls were hybridized on MethylationEPIC BeadChip arrays, and CellPhoneDB was used to infer changes in the crosstalk between monocytes and other immune cell types.
[Genome Medicine] |
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| Scientists performed a pseudotime analysis of SARS-CoV-2 infection using publicly available scRNA-seq data from human bronchial epithelial cells and colon and ileum organoids.
[Communications Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers revealed the structures of GP38 bound with a human chimeric 13G8 mouse monoclonal antibody (mAb), and a newly isolated CC5-17 mAb from a human survivor.The broad-spectrum potential of c13G8 and CC5-17 and the practicality of using them against Aigai virus were examined.
[Nature Communications] |
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| Most recombinant Hepatitis C virus glycoprotein vaccines, which usually include only E2, induce only weak neutralizing antibody responses. Therefore, investigators described recombinant soluble E1E2 immunogens that were generated by permutation of the E1 and E2 subunits.
[Nature Communications] |
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| The authors constructed a probiotic E. coli clone harboring the genetic locus responsible for biogenesis of serotype 14 pneumococcal capsular polysaccharides as a model antigen.
[NPJ Vaccines] |
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| Investigators found temporal coordination of two independent innate immunity pathways in controlling Legionella pneumophila infection: inflammasome activation, and CCR2-mediated monocyte-derived dendritic cell recruitment.
[European Journal of Immunology] |
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| Scientists explored the potential roles of Th9 cells in the immunopathogenesis of experimental cerebral malaria. In splenocytes sourced from uninfected, PbA and Py infected mice, Th9 cells were characterised by flow cytometry, cell sorting, and qPCR.
[Molecular Immunology] |
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| Study selection, risk of bias assessment, data extraction, and assessment of the certainty of evidence using the GRADE method were performed independently by two authors.
[BJOG-An International Journal of Obstetrics and Gynaecology] |
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| An analysis released Nov 22 by UK health officials indicates that even one dose of the monkeypox vaccine provides strong protection against the virus.
[STAT News] |
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| The US Department of Justice charged two Cambodian wildlife officials and several members of a Hong Kong-based primate supply company with illegally exporting hundreds—and potentially more than 2000— cynomolgus macaques, an endangered species, to the United States for research.
[Science Insider] |
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| January 22 – 25, 2023
Santa Fe, New Mexico, United States |
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| | AstraZeneca – Gothenburg, Sweden OR Gaithersburg or Wilmington, United States |
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| | University of Oxford – Oxford, United Kingdom |
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| | University of Utah – Salt Lake City, Utah, United States |
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| | Takeda – San Diego, California |
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| | University of Toronto Mississauga – Mississauga, Ontario, Canada |
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