 | | Vol. 10.48 – 14 December, 2022 |
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| Scientists isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent health care workers, focusing on the IGHV1-69 gene, which has the highest level of allelic variation of all IGHV genes.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that while primary human airway epithelia had functional inflammasomes and supported SARS-CoV-2 replication, they were not the source of IL-1β released upon infection.
[Cell Host & Microbe] |
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| Mutations acquired by SARS-CoV-2 S variants likely influence virus-target cell interaction. Using single-virus tracking, scientists observed how viruses carrying a variant spike protein interacted with target cells.
[Science Advances] |
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| Researchers described the establishment of nasopharyngeal and bronchial organoids from healthy individuals and chronic obstructive pulmonary disease that recapitulated the disease at the individual level.
[Nature Communications] |
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| The authors reported that cell-intrinsic interactions between the spike glycoprotein of SARS-CoV-2 and epithelial/endothelial cells were sufficient to induce barrier dysfunction in vitro and vascular leak in vivo, independently of viral replication and the ACE2 receptor.
[Nature Communications] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | Researchers evaluated the humoral and cellular responses against wild-type and Omicron SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents.
[Signal Transduction and Targeted Therapy] |
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| Scientists studied main protease (Mpro)-mediated processing of the nsp7-11 polyprotein, whose mature products include cofactors of the viral replicase, and identified the order of cleavages.
[Science Advances] |
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| The authors characterized the repertoire and epitope specificity of antibodies elicited by infection with the Beta, Gamma, and WA1 ancestral variants and assessed their cross-reactivity to these and the more recent Delta and Omicron variants.
[Nature Communications] |
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| Scientists generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bound with high affinity in the central region of the surface-bound M protein.
[EMBO Molecular Medicine] |
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| Cell type deconvolution analysis revealed a significant enrichment for monocyte markers and different subsets of dendritic cells as mediators for optimal B cell responses and significant increase of anti-stalk antibodies in sera.
[NPJ Vaccines] |
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| Scientists investigated the expression level of 18 miRNAs involved in the proliferation and differentiation of CD4+ T cells in a target and a control group.
[International Immunopharmacology] |
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| Using a mouse model, researchers investigated the potential of oral immunization with a novel lipid adjuvant followed by local vaginal application of an inflammatory agent to protect against primary HSV-2 infections.
[American Journal of Reproductive Immunology] |
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| The authors focus on certain immunological elements that have recently yielded exciting data, and highlight the importance of taking a holistic approach to understanding the interaction of M. tuberculosis with the many host cells that contribute to the development of protective immunity.
[Cell] |
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| Investigators summarize the current understanding of the roles of androgens, estrogens, and progesterone in the regulation of virus entry receptors and disease progression of coronavirus disease 2019, as well as their therapeutic value.
[Nature Reviews Endocrinology] |
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| Long COVID had begun appearing on death certificates for a small percentage of people who have died during the pandemic, but that tiny fraction of records only hints at the whole story, two experts told STAT.
[STAT News] |
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| Jeremy Farrar, director of the Wellcome Trust, one of the largest nongovernmental science funders, will step down early next year to become the chief scientist at the World Health Organization (WHO).
[ScienceInsider] |
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| COVAX, the unprecedented global effort to distribute COVID-19 vaccines more fairly, was set to wind down over the next 2 years. The decision isn’t final, but critics of COVAX—many from poorer countries—would not mourn its demise.
[ScienceInsider] |
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| January 23 – 25, 2023
Breckenridge, Colorado, United States |
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| | North Carolina State University – Raleigh, North Carolina, United States |
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| | Helmholtz Munich – Neuherberg, Germany |
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| | Medpace – Remote, Austria |
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| | Bristol Myers Squibb – Uxbridge, England, United Kingdom |
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| | STEMCELL Technologies, Inc. – Boston, Massachusetts, United States |
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