 | | Vol. 11.00 – 4 January, 2023 |
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| The authors showed that both vaccine-derived and naturally acquired immunity independently reduced the infectiousness of persons with Omicron variant SARS-CoV-2 infections in a prison setting.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers examined the function of classical CD14+ monocytes in patients with mild and moderate COVID-19 during the acute phase of infection and in healthy individuals.
[Nature Communications] |
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| Scientists performed a randomized, open-label, in hospitalized patients with severe COVID-19 (n = 134) within four risk groups, randomized to standard of care or standard of care plus convalescent/vaccinated anti-SARS-CoV-2 plasma.
[Nature Cancer] |
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| Investigators constructed a novel mRNA delivery system, using IC8/Mn lipid nanoparticles with high immunogenicity, via introducing a stimulator of interferon genes agonist manganese based on a newly synthesized ionizable lipid, IC8.
[Science Advances] |
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| Scientists compared in SARS-CoV-2 naïve donors B and T cell responses to two mRNA vaccine doses administered 3-4 versus 16 weeks apart.
[Iscience] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
| | Scientists demonstrated a markedly altered viral reservoir profile of long-term antiretroviral therapy-treated individuals, characterized by large clones of intact proviruses preferentially integrated in heterochromatin locations, most prominently in centromeric satellite/micro-satellite DNA.
[Cell Host & Microbe] |
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| A single intramuscular injection of NM1TFV, but not NTAF, demonstrated monthslong antiviral activities in both hepatitis B virus-transgenic and human hepatocyte transplanted mice.
[Science Advances] |
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| Analyzing human gasdermin D (GSDMD) variants showed that most people were susceptible to Zika virus (ZIKV)-induced cytotoxicity, except for those with variants that resisted ZIKV cleavage or were defective in oligomerizing the N-terminus GSDMD cleavage product.
[Molecular Therapy-Oncolytics] |
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| In bone marrow-derived macrophages, both Axl and Mer receptors played a role in the efferocytosis of proapoptotic T cells from Trypanosoma cruzi-infected mice.
[Communications Biology] |
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| Researchers described cellular and antibody immune responses present in survivors of Lassa fever (N = 370) and their exposed contacts (N = 170) in a Lassa virus endemic region in Nigeria.
[Scientific Reports] |
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| The authors review evidence regarding the impact of pre-existing humoral and T cell immune responses to outcomes of SARS-CoV-2 infection and vaccination.
[Nature Reviews Immunology] |
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| Scientists raise the perspective of gut interkingdom interactions involving C. albicans and enteric viruses, with a special focus on biofilms, prostaglandin E2 and viral replication.
[iScience] |
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| Quantum Leap Healthcare Collaborative, sponsor of the I-SPY COVID Trial, announced that the cyproheptadine arm of the study has been terminated.
[PR Newswire] |
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| February 19 – 22, 2022
Banff, Alberta, Canada |
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| | Rutgers New Jersey Medical School – Newark, New York, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Pfizer – Pearl River, New York, United States |
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| | North Carolina State University – Raleigh, North Carolina, United States |
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| | Westlake University – Hangzhou, China |
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