 | | Vol. 11.04 – 1 February, 2023 |
| |
|
|
| Adults aged 18–50 years with no previous malaria vaccinations or infections received the monoclonal antibody CIS43LS in a single, open-label dose of 1 mg/kg, 5 mg/kg, or 10 mg/kg intravenously, or 5 mg/kg or 10 mg/kg subcutaneously.
[Lancet Infectious Diseases] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
| |
|
|
| Researchers described a polymeric Toll-like receptor 7 agonist nanoparticle (TLR7-NP) adjuvant, which enhanced lymph node targeting, and led to persistent activation of immune cells and broad immune responses. They tested responses to this TLR7-NP using human tonsil organoids, and other methods.
[Nature Materials] |
|
|
|
| Using coldspot-guided antibody discovery, a screening approach that focused on portions of the virus spike glycoprotein that were both functionally relevant and averse to change, the authors identified human neutralizing antibodies to highly conserved viral epitopes.
[Science Immunology] |
|
|
|
| Scientists investigated intrahost evolution and genetic diversity of lineage B.1.517 during a SARS-CoV-2 chronic infection lasting for 471 days with consistently recovered infectious virus and high viral genome copies.
[Cell Reports Medicine] |
|
|
|
| Researchers showed cocirculation of three major SARS-CoV-2 variants of concern, Alpha, Delta, and Gamma, in this species, long after their last detection in humans.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
|
|
|
| Investigators showed that a high affinity receptor decoy protein in which a modified ACE2 ectodomain was fused to a single domain of an immunoglobulin heavy chain Fc region dramatically suppressed virus loads in mice upon challenge with a high dose of parental SARS-CoV-2 or Omicron variants.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
|
|
|
| Scientists investigated how indiscriminate DNA sensors, such as cyclic GMP-AMP synthase (cGAS), made the self-nonself distinction.
[Immunity] |
|
|
|
| Hepatitis B virus (HBV) dextramer+CD8 T cells were analyzed ex vivo for coexpression of checkpoint/differentiation markers, transcription factors, and cytokines.
[Gut] |
|
|
|
| Scientists reported a method for selectively labeling bacterial proteomes using a bifunctional amino acid, photo-ANA, which enabled simultaneous analysis of bacterial proteome reprogramming and pathogen–host protein interactions of Salmonella enterica serovar Typhimurium during infection.
[Nature Chemical Biology] |
|
|
|
| The authors profiled B cells from the central nervous system (CNS) of murine models of intracranial viral infections and autoimmunity, and identified a population of clonally expanded, antibody-secreting cells that had undergone class-switch recombination and extensive somatic hypermutation.
[Acta Neuropathologica] |
|  |
|
|
|
| The authors thoroughly discuss the role of ACE2 in SARS-CoV infection, and ACE2 therapeutics.
[Cell] |
|
|
|
| Scientists propose that the type I interferon defensive immune response to SARS-CoV-2 infection in the choroid plexus poses a risk to cognitive function if not resolved in a timely manner.
[Nature Immunology] |
|
|
|
|
| The FDA withdrew the authorization of Evusheld, the latest antibody therapy to be rendered ineffective by the mutations the virus has picked up. Evusheld, unlike other antibody therapies, was not for infected patients, but rather was given as a pre-exposure treatment to people at high risk for severe Covid-19.
[STAT News] |
|
|
|
| The Biden administration has announced that it plans to end the pandemic’s classification as a public health emergency on May 11 2023, a move that will usher in a complex wave of policy changes that may complicate Americans’ testing and treatment options for the disease.
[The New York Times] |
|
|
|
|
| April 17 – 19, 2023
Freiburg in Breisgau, Germany |
|
|
|
|
|
| | Karolinska Institutet – Solna, Sweden |
|
|
|
| | Novartis – Munich, Germany |
|
|
|
| | LMU Munich – Munich, Germany |
|
|
|
| | The University of Edinburgh – Edinburgh, United Kingdom |
|
|
|
| | Rutgers New Jersey Medical School – Newark, New York, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
