 | | Vol. 11.05 – 8 February, 2023 |
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| The authors routinely collected respiratory samples covering both imported and local cases in Beijing, and then randomly selected samples collected between January and December, 2022 for analysis.
[Lancet] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers demonstrated that broadly neutralizing antibodies could be isolated from peripheral blood mononuclear cells of convalescent patients using SARS-CoV-2 receptor binding domains carrying epitope-specific mutations.
[Nature Communications] |
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| Scientists analyzed the immunity of individuals that initially received two doses of mRNA vaccine and either received a booster vaccination, recovered from a breakthrough infection, or both.
[Nature Communications] |
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| Investigators longitudinally analyzed antibody, B cell, CD4+, and CD8+ T cell vaccine responses in 27 hemodialysis patients and 26 low-risk control individuals.
[Cell Reports Medicine] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors studied unrelated children with inherited complete IRF1 deficiency and early-onset, multiple, life-threatening diseases caused by weakly virulent mycobacteria and related intramacrophagic pathogens.
[Cell] |
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| Researchers used antigen-reactive T cell enrichment to investigate fungus-reactive T-helper cells in peripheral blood ofpatients with cystic fibrosis and healthy controls.
[Journal Of Clinical Investigation] |
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| Scientists generated myeloid-specific and hepatocyte-specific DHX9 knockout mice and confirmed that DHX9 was crucial for host resistance to RNA virus infections in vivo.
[Science Advances] |
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| Using a zebrafish Gaucher disease model, the authors found that the mutation GBA1 N370S, predominant among Ashkenazi Jews, increased resistance to tuberculosis through the microbicidal activity of glucosylsphingosine in macrophage lysosomes.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Investigators performed single-cell RNA-sequencing and single-cell ATAC-sequencing of CD8+ T cells responding to LCMV-Armstrong or LCMV-Clone 13, which resulted in acute or chronic infections, respectively.
[Plos Biology] |
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| After detailed analysis of the viral neuraminidase sequence of human H5N1 viruses, scientists studied the role of A46D, L204M, S319F and S430G mutations in virus fitness in vitro and in vivo.
[PLOS Pathogens] |
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| Out of 138 non-lesion samples, viral DNA was found in 92.3% saliva, 85.7% semen, 86.2% oropharyngeal-swabs, 51.7% plasma, 46.1% stool, and 9.5% urine samples. Viral load quantified by digital-PCR widely varied, but tended to be higher in oropharyngeal-swabs, saliva, and stool.
[Iscience] |
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| Researchers discuss how findings related to inborn errors of human type I IFN immunity and life-threatening COVID-19 illustrate the unpredictable, but considerable, contribution of the study of rare human genetic diseases to basic biology and public health.
[Journal Of Clinical Investigation] |
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| The authors review the potential, and factors that require consideration, for using environmental samples via eDNA/eRNA) as a proxy for infection of host organisms in connected habitats, for pathogen monitoring and surveillance, and for early warning systems for disease.
[Trends In Parasitology] |
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| Analysis reveals the signature of the antiviral drug molnupiravir in SARS-CoV-2 sequences riddled with mutations.
[Nature News] |
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| The Danish health authorities have recalled the antibiotic medication Dicillin after it was linked to an outbreak of multiresistant bacteria cases, which doctors fear could be just the tip of the iceberg.
[The Copenhagen Post] |
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| March 31, 2023
Amsterdam, The Netherlands |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | STEMCELL Technologies – Oxford, England, United Kingdom |
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| | Karolinska Institutet – Solna, Sweden |
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| | LMU Munich – Munich, Germany |
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| | Rutgers New Jersey Medical School – Newark, New York, United States |
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