 | | Vol. 11.06 – 15 February, 2023 |
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| The authors described a deep mutational scanning platform based on non-replicative pseudotyped lentiviruses that directly quantified how large numbers of spike mutations impacted antibody neutralization and pseudovirus infection, and used it to produce libraries of the Omicron BA.1 and Delta spikes.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators demonstrated that plasmacytoid dendritic cells (pDC) were the predominant IFN-I/λ source following their sensing of SARS-CoV-2-infected cells, and by exploring the pDC response in SARS-CoV-2 patients, found that pDC responsiveness inversely correlated with the severity of the disease.
[Nature Communications] |
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| To assess whether IgM development was also associated with longer-lasting immunity, scientists analyzed anti-SARS-CoV-2 spike protein IgG and IgM, and anti-nucleocapsid IgG in 1872 vaccine recipients at different time points.
[Ebiomedicine] |
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| Researchers assessed neuropathological alterations in 24 COVID-19 patients and 18 matched controls who died due to pneumonia/respiratory failure, and detected SARS-CoV-2-immunoreactive neurons were detected in the dorsal medulla and in the substantia nigra of five COVID-19 subjects.
[Npj Parkinson’S Disease] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists reported that the compound trifluoromethyl-tubercidin impaired the association of host cap RNAs with the viral polymerase basic protein 2 subunit in human lung explants and in vivo in mice.
[Science] |
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| Investigators identified a population of innate lymphocytes that they termed tissue-resident memory-like natural killer cells.
[Immunity] |
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| Scientists developed IOMA anitobdy germline–targeting envelope glycoprotein immunogens, and evaluated a sequential immunization regimen in transgenic mice expressing germline-reverted IOMA antibodies.
[Science Immunology] |
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| Using multiparameter flow cytometry, researchers found that natural killer cells degranulated and releasde IFN-γ upon stimulation with antibody-opsonized Plasmodium falciparum merozoites.
[Science Translational Medicine] |
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| The authors presented the discovery, in vitro characterization, and in vivo efficacy testing of two cross-neutralizing monoclonal antibodies, one targeting both human parainfluenza virus types one and three, and the other targeting both respiratory syncytial virus and human metapneumovirus.
[Nature Communications] |
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| Using primary mouse bone marrow-derived macrophages to examine the host response to M. catarrhalis infection, global transcriptomic and targeted cytokine analyses revealed activation of immune signaling pathways by both membrane-bound and cytosolic pattern-recognition receptors.
[EMBO Journal] |
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| Using an ascending mouse model of Group B Streptococcus (GBS) infection to measure placental cell state changes over time following infection with a β-h/c-deficient and isogenic wild type GBS strain, investigators showed that GBS modulated innate immune cell states, allowing worse outcomes.
[Molecular Systems Biology] |
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| The authors summarize the current understanding of how C. trachomatis establishes its intracellular replication niche, how its metabolism functions in the host cell, how it can defend itself against the cell autonomous and innate immune response.
[Nature Reviews Microbiology] |
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| Scientists discuss the evidence linking Epstein–Barr virus to the development of multiple sclerosis, and the mechanisms by which the virus is thought to cause the disease.
[Nature Reviews Neurology] |
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| The World Health Organization (WHO) has quietly shelved the second phase of its much-anticipated scientific investigation into the origins of the COVID-19 pandemic, citing ongoing challenges over attempts to conduct crucial studies in China.
[Nature News] |
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| April 11 – 12, 2023
New York, New York, United States |
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| | Helmholtz Centre for Infection Research – Braunschweig, Germany |
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| | Gothenburg University – Gothenburg, Sweden |
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| | The University of Konstanz – Konstanz, Germany |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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| | Baylor College of Medicine – Houston, Texas, United States |
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