 | | Vol. 11.07 – 23 February, 2022 |
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| Scientists investigated the duration and effectiveness of immunity in a prospective cohort of asymptomatic health care workers in the United Kingdom who underwent routine PCR testing.
[New England Journal of Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers combined a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associated specific immune trajectories with upper airway viral containment.
[Nature Immunology] |
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| The authors reported the correlates of durability of humoral and cellular immune responses in 20 rhesus macaques immunized with single-shot Ad26.COV2.S and the immunogenicity of a booster shot at 8 to 10 months following the initial immunization.
[Science Translational Medicine] |
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| Investigators reported that PF-332 exerted equipotent in vitro activity against the four SARS-CoV-2 variants of concerns and that it could completely arrest replication of the alpha variant in primary human airway epithelial cells grown at the air-liquid interface.
[Nature Communications] |
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| Researchers found that 34 risk genes were significantly associated with severe COVID-19, and the number of highly expressed genes increased with the severity of COVID-19.
[Genome Medicine] |
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| Via targeted deletion of virus-recognition innate immune pathways, the authors identified TLR7-MyD88 signaling was crucial for production of antiviral interferons, whereas TLR2 is responsible for the inflammatory IL-6 response.
[EMBO Journal] |
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| Scientists demonstrated that citrulline administration was more efficient than arginine in increasing arginine plasma levels and restoring T cell mitochondrial function and proliferation while reducing sepsis-induced T regulatory cells and myeloid-derived suppressor cells expansion.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Investigators evaluated the immune properties of the HLA-A2 restricted CD8+ T cell epitopes containing mutations from B.1.1.7.
[iScience] |
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| Researchers provided a detailed analysis of the B cell response to SARS-CoV-2 in unexposed individuals.
[iScience] |
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| The authors reported the identification of hepatitis C virus NS5A inhibitors Pibrentasvir and Ombitasvir as SARS-CoV-2 exonuclease inhibitors.
[Communications Biology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists investigated influenza vaccination among adults from the Ha Nam cohort, who were purposefully selected to include 72 with and 28 without documented influenza A infection during the preceding nine years.
[Nature Medicine] |
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| Researchers showed that the transcription factor Tcf1 was required in resting central memory CD8+ T cells to generate secondary effector CD8+ T cells and to clear pathogens during recall responses.
[Nature Immunology] |
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| Investigators analyzed the need for both infection and antigen presentation at the effector phase, using an in vivo sequential transfer model to time their availability.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Using Powassan virus lethal and sub-lethal challenge models, the authors showed that robust B and T cell responses were necessary for immune protection.
[Cell Reports] |
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| Researchers found that human mucosa-associated invariant T (MAIT) cells are hypersensitive to leukocidin ED-mediated lysis and lost on exposure to the toxin, leaving a T cell population devoid of MAIT cells.
[Journal of Immunology] |
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| Investigators studied the relationship between human cytomegalovirus reactivation and adaptive NK cells in 70 patients monitored weekly until 100 days after hematopoietic stem cell transplantation.
[Bone Marrow Transplantation] |
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| Scientists encourage the continued consideration of the use of the antioxidant and anti-inflammatory agent, melatonin, as a countermeasure to a SARS-CoV-2 infection.
[Cellular and Molecular Life Sciences] |
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| Investigators discuss the emerging SARS-CoV-2 variants and the structural basis for antibody-mediated neutralization of SARS-CoV-2 and neutralizing antibodies classification.
[PLoS Pathogens] |
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| In January 2023, the US National Institutes of Health (NIH) will begin requiring most of the 300,000 researchers and 2,500 institutions it funds annually to include a data-management plan in their grant applications — and to eventually make their data publicly available
[Nature News] |
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| In an effort to shed light on COVID-19 and its complications, the Howard Hughes Medical Institute (HHMI) provided $10 million to HHMI Investigators at Yale.
[Yale School of Medicine] |
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| April 4 – 8, 2022
Saint Malo, France/div> |
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| | Hong Kong University – Hong Kong, China |
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| | St. Jude Children’s Research Hospital – Location |
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| | Florida International University – Miami, Florida, United States |
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| | Babraham Institute – Babraham, England, United Kingdom |
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| | St. Jude Children’s Research Hospital – Location |
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