 | | Vol. 11.08 – 1 March, 2023 |
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| A network of clinicians from 19 countries provided data to describe the clinical characteristics and outcomes of mpox in a cohort of people with HIV and low CD4 cell counts.
[Lancet] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using six pMHC-multimers in a cohort with early and frequent sampling, scientists defined the phenotype and kinetics of recalled and primary T cell responses following Delta or Omicron breakthrough infection in previously vaccinated individuals.
[Immunity] |
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| The data set analyzed includes COVID-19 patients hospitalized between January 2020 and January 2022 in 52 countries. The authors investigated how symptoms on admission, co-morbidities, risk factors, and treatments varied by age, sex, and other characteristics.
[International Journal Of Epidemiology] |
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| Researchers biobanked airway organoids by preserving stem cell function, and then optimized viral infection with H1N1/PR8 and comprehensively characterized epithelial responses to SARS-CoV-2 infection in phenotypically stableairway organoids from 20 different subjects.
[Stem Cell Reports] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Using murid herpesvirus 4, a mouse gammaherpesviruse, scientists showed that after infection, lung-resident and recruited group 2 innate lymphoid cells exhibited a reduced ability to expand and produce type 2 cytokines in response to house dust mites, thereby contributing to protection against asthma.
[Science Immunology] |
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| Researchers assessed the impact of prolonged, antibody-mediated CD4+ T cell depletion on gut integrity and natural history of SIV infection in African Green Monkeys.
[Nature Communications] |
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| The authors demonstrated that despite the absence of pyroptosis, Gasdermin-D was active at the early stages of Leishmania infection in macrophages, allowing transient cell permeabilization, potassium efflux, and NLRP3 inflammasome activation.
[Nature Communications] |
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| Using a surrogate neutralization assay, researchers characterized the evolution of the serological neutralizing antibody landscape in young children as they transitioned between sequential GII.4 pandemic variants of human norovirus.
[Cell Reports Medicine] |
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| Investigators successfully induced systemic and mucosal antibody responses against both rotavirus and norovirus following inoculation of recombinant rotaviruses expressing the human norovirus capsid proteins.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Antagonism of IL-18 binding protein (IL-18BP) with a “decoy-to-the-decoy” IL-18 construct that did not signal, but rather bound IL-18BP, resulted in enhanced innate lymphoid cell and T cell responses and improved parasite control.
[Cell Reports] |
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| The authors consider the impact of specific comorbidities, and overall multimorbidity, on the three mechanistically distinct phases of COVID-19, and discuss the utility of host genetics as a route to causal inference by eliminating many sources of confounding
[Nature Medicine] |
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| Clinical data have convinced Atea Pharmaceuticals it cannot make the numbers add up in dengue fever. Based on the results, the antiviral biotech calculates it would take at least three years and cost several hundred million dollars to run phase II studies, prompting it to put the program on the back burner.
[Fierce Biotech] |
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| An 11-year-old girl in southern Cambodia who died last week after being infected with avian influenza A (H5N1) had a different strain than the one causing mass deaths in wild and domestic birds globally, says the scientist who led the effort to sequence viral samples from the girl.
[Nature News] |
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April 16 – 19, 2023
Snowbird, Utah, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Cornell University – Ithaca, New York, United States |
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| | The University of Melbourne – Melbourne, Australia |
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| | Twincore GmbH – Hannover, Germany |
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| | The University of Edinburgh – Edinburgh, Scotland, United Kingdom |
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