 | | Vol. 11.11 – 22 March, 2023 |
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| Scientists reported the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant, cord blood cells combined with haploidentical stem cells from an adult, to treat acute myeloid leukemia.
[Cell] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using “spheromer” peptide-MHC multimer reagents, investigators analyzed healthy subjects receiving two doses of the Pfizer/BioNTech BNT162b2 vaccine.
[Immunity] |
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| The authors systematically examined changes in transcript profiles caused by SARS-CoV-2 infection at different multiplicities of infection for lung airway organoids, lung alveolar organoids, and cardiomyocytes, and identified several genes that were generally implicated in controlling SARS-CoV-2 infection.
[Nature Cell Biology] |
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| Investigators showed that a half-life–extended monoclonal antibody provided about 50% protection against symptomatic COVID-19 in SARS-CoV-2–naïve adults at serum neutralizing antibody titers on the order of 1:30.
[Science Translational Medicine] |
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| Using serum proteomics and RNA-sequencing, the authors investigated the immune changes in patients treated with nasal Foralumab.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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Using both C57BL/6 and BALB/c mice, researchers analyzed immune cells in the pleural cavity. While infection drove monocyte recruitment in both strains, only in C57BL/6 mice were monocytes able to efficiently integrate into the resident pool.
[Immunity] |
| | Investigators used time-lapse fluorescence microscopy to show that contact with extracellular Mycobacterium tuberculosis aggregates triggers macrophage plasma membrane perturbation, cytosolic calcium accumulation, and pyroptotic cell death.
[EMBO Journal] |
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| Researchers reported that protection was mainly mediated by antibodies, although neuraminidase-specific T cells also contributed. Both antigen-presenting cells-targeting and antigen bivalency were crucial for vaccine efficacy.
[Molecular Therapy] |
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| Scientists experimentally infected wild-type and stress keratin 17 knockout mice with a murine papillomavirus in the female reproductive tract, in the presence or absence of exogenous estrogen, for 6 months.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors summarize insights into the function of viral proteins in Crimean–Congo haemorrhagic fever virus (CCHFV) pathogenesis, the current understanding of CCHF, and the state of treatments and vaccines for the disease.
[Nature Reviews Microbiology] |
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| The multifarious mechanisms altering the immune system induced by helminths have significant implications on the control of coinfecting pathogens such as viruses. Scientists explore the recent literature to highlight the main immune alterations and mechanisms that affect the control of viral coinfection.
[Trends In Parasitology] |
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| “This is a clue and it’s an important one,” says scientist overseeing the global health agency’s probe into what sparked the pandemic.
[Science Insider] |
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| The number of high-containment labs studying the deadliest known pathogens is booming. A new analysis warns the growing number of labs is raising risks of an accidental release or misuse of germs such as the Ebola and Nipah viruses.
[Science Insider] |
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| April 23 – 26, 2023
Snowbird, Utah, United States |
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| | Pfizer, Inc. – Any North American Pfizer Site |
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| | Rutgers New Jersey Medical School – Newark, New Jersey, United States |
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| | Umeå University – Umeå, Sweden |
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| | University of Cambridge – Cambridge, England, United Kingdom |
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| | University Hospital Duesseldorf – Düsseldorf, Germany |
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