 | | Vol. 11.13 – 5 April, 2023 |
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| Researchers compared immune responses and preclinical efficacy of the mRNA vaccine BNT162b2, the adenovirus-vectored spike vaccine Ad2-spike, and the live-attenuated virus vaccine candidate sCPD9 in Syrian hamsters, using both homogeneous and heterologous vaccination regimens.
[Nature Microbiology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The most potent compound inhibited the papain-like protease with kinact/KI= 9,600 M−1 s−1, achieved sub-μM EC50 values against three SARS-CoV-2 variants in mammalian cell lines, and did not inhibit a panel of human deubiquitinases at >30 μM concentrations of inhibitor.
[Nature Communications] |
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| Researchers compared the memory CD8 T cell response against a common SARS-CoV-2 epitope after vaccination, infection, or both.
[Cell Reports] |
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| MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| A population of IRF4+ T cells coexpressed the transcription factor BCL6 during Mycobacterium tuberculosis (Mtb) (Mtb) infection, and deletion of BCL6 in CD4+ T cells resulted in reduction of TFH-like cells, impaired localization within granuloma-associated lymphoid tissue, and increased Mtb burden.
[Nature Immunology] |
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| The authors analyzed peripheral blood γδ T cells from a South African adolescent cohort and showed that a unique CD8+ γδ T cell subset with features of “memory inflation” expanded in chronic Mycobacterium tuberculosis infection.
[Science Immunology] |
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| Researchers showed that a subcutaneous vaccine consisting of live Zika virus electrostatically entrapped in a self-adjuvanting hydrogel recruited immune cells at the injection site and provided mice with effective protection against a lethal viral challenge.
[Nature Biomedical Engineering] |
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| Human pre-patent Schistosoma mansoni infection pulmonary sputum samples revealed a mixed type-1/type-2 inflammatory cytokine profile, whilst a case-control study showed no significant pulmonary cytokine changes in endemic patent infection.
[Nature Communications] |
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| Investigators uncovered the requirement of host co-factors for endosomal antiviral inhibition through high-throughput proteomics and lipidomics in cellular models of interferon-induced transmembrane proteins restriction.
[EMBO Journal] |
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| Scientists explored a class of adjuvant that harnessed mucosal-associated invariant T (MAIT) cells, and showed evidence that intranasal immunization of MAIT cell agonists co-administered with protein induced protective humoral immunity and immunoglobulin A production.
[Cell Reports] |
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| The authors describe several approaches that probe different regions of the high-dimensional sequence space and comment on how combinations of these methods may offer novel insight into immune–pathogen coevolution.
[Trends In Immunology] |
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| Scientists review the impact of infection by exogenous retroviruses on the expression of human endogenous retroviruses (HERVs), the effect of HERVs on the pathogenicity of HIV and human T-cell lymphotropic viruses and on the severity of the diseases caused by them, and more.
[Trends In Microbiology] |
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| The healthcare giant’s pharmaceutical unit Janssen announced the end of work on the adult respiratory syncytial virus vaccine program and the discontinuation of a pivotal Phase III trial.
[Fierce Biotech] |
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| Patients and patient advocates are calling on the US National Institutes of Health (NIH) to reconsider its decision to include exercise trials in its RECOVER initiative, which aims to study and find treatments for long COVID.
[Nature News & Views] |
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| April 25 – 26, 2023
London, England, United Kingdom |
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| | The Beckman Research Institute of City of Hope – Duarte, California, United States |
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| | Pfizer, Inc.- Cambridge, Massachusetts, United States |
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| | Hudson Institute of Medical Research – Melbourne, Australia |
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| | Dana-Farber Cancer Institute and Harvard Medical School – Boston, Massachusetts, United States |
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| | Rutgers New Jersey Medical School – Newark, New Jersey, United States |
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