 | | Vol. 11.14 – 12 April, 2023 |
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| By screening a library of enterohemorrhagic Escherichia coli mutants, scientists uncovered EhaF, an uncharacterized protein, as an inhibitor of innate immune responses including type I interferons.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers developed an intranasal vaccine candidate based on a live attenuated influenza virus with a deleted NS1 gene that encodes cell surface expression of the receptor-binding-domain of the SARS-CoV-2 spike protein.
[Nature Communications] |
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| The authors demonstrated that all SARS-CoV-2 variants of concern possessed the ability to suppress major histocompatibility complex class I (MHC-I) expression.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers investigated the effect of an evolving spike positive charge in SARS-CoV-2 variants and subsequent interactions with heparan sulfate and the ACE2 in the glycocalyx.
[Cell Reports Physical Science] |
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| Scientists generated a panel of 17 human cell lines overexpressing SARS-CoV-2 entry factors and tested their ability to support viral infection.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors described a BG505 SOSIP trimer, termed GT1.2, to optimize binding to gl-CH31, the unmutated common precursor of the CH30-34 broadly neutralizing antibody lineage that acquired a large CDRH1 insertion.
[Cell Reports Medicine] |
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| Investigators showed that extracellular vesicle (EV)+ cell abundance increased during viral infection and that EVs preferentially bound to activated, but not naive, CD8+ T cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Researchers characterized mouse PYHIN IFI207, which they found was not involved in DNA sensing but rather was required for cytokine promoter induction in macrophages.
[Cell Reports] |
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| Using a serum-free in vitro system, scientists further delineated the role of TGF-β signaling in mediating HIV-1 infection of activated and resting memory CD4+ T cells.
[Journal of Virology] |
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| Investigators assessed the ability of Polymyxin B to neutralize the immune-stimulatory properties of outer membrane vesicles (OMVs) whilst modulating the uptake of OMVs in human immune cells.
[Journal of Antibiotics] |
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| The authors highlight dysregulated immune responses induced by SARS-CoV-2 and Mtb, their potential interplay, and implications for co-infection in the lungs.
[iScience] |
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| The US national emergency to respond to the COVID-19 pandemic ended Monday as President Joe Biden signed a bipartisan congressional resolution to bring it to a close after three years.
[The Associated Press] |
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| May 28 – 31, 2023
Vancouver, British Columbia, Canada |
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| | National Health Research Institutes – Zhunan, Taiwan |
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| | Sandia National Laboratories – Livermore, California, United States |
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| | The Beckman Research Institute of City of Hope – Duarte, California, United States |
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| | Pfizer, Inc.- Cambridge, Massachusetts, United States |
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| | Hudson Institute of Medical Research – Melbourne, Australia |
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