Immunology of Infectious Disease News Volume 11.16 | Apr 26 2023

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    2023-04-26 | IIDN 11.16


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.16 – 26 April, 2023
    TOP STORY

    CD4+ T Cell-Mediated Recognition of a Conserved Cholesterol-Dependent Cytolysin Epitope Generates Broad Antibacterial Immunity

    Researchers identified an immunodominant CD4+ T cell epitope derived from pneumolysin, a member of the bacterial cholesterol-dependent cytolysins.
    [Immunity]

    Full ArticleGraphical Abstract
    View tips on how to organize your lab bench space.
    PUBLICATIONSRanked by the impact factor of the journal

    Tight Junction Protein Occludin Is an Internalization Factor for SARS-CoV-2 Infection and Mediates Virus Cell-to-Cell Transmission

    SARS-CoV-2 infection altered occludin, the tight junction protein, distribution and expression and caused syncytium formation that led to viral spread.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Self-Replicating RNA Nanoparticle Vaccine Elicits Protective Immune Responses against SARS-CoV-2

    To improve the delivery and vaccine efficacy of self-replicating RNA (repRNA), scientists developed a self-assembling liposome-protamine-RNA nanoparticle with highly efficient encapsulation and transfection of repRNA.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Macrophage ACE2 Is Necessary for SARS-CoV-2 Replication and Subsequent Cytokine Responses That Restrict Continued Virion Release

    Investigators found that SARS-CoV-2 could enter, but did not replicate within, ACE2-deficient human primary macrophages and did not induce proinflammatory cytokine expression.
    [Science Signaling]

    Full Article

    Reticulons Promote Formation of ER-Derived Double-Membrane Vesicles That Facilitate SARS-CoV-2 Replication

    Researchers clarified how SARS-CoV-2 hijacks host factors to construct the double-membrane vesicles (DMVs). They showed that the endoplasmic reticulum (ER) morphogenic proteins reticulon-3 (RTN3) and RTN4 helped drive DMV formation, enabling viral replication.
    [Journal of Cell Biology]

    Full Article

    COVID-19 Relapse Associated with SARS-CoV-2 Evasion from CD4+ T Cell Recognition in an Agammaglobulinemia Patient

    Viral genetic sequencing demonstrated that SARS-CoV-2 had evolved during the infection period, with at least five mutations associated with host cellular immune recognition.
    [iScience]

    AbstractGraphical Abstract

    HSV-2 Triggers Upregulation of MALAT1 in CD4+ T Cells and Promotes HIV Latency Reversal

    Scientists tested whether HSV-2 induced changes in the cells that facilitate HIV-1 reactivation and replication and tested this in human CD4+ T cells and 2D10 cells, a model of HIV-1 latency.
    [Journal of Clinical Investigation]

    Abstract

    CD30 Co-Stimulation Drives Differentiation of Protective T Cells during Mycobacterium tuberculosis Infection

    Researchers compared the gene expression profiles of T cells in pulmonary granulomas, bronchoalveolar lavage, and blood of Mycobacterium tuberculosis-infected rhesus macaques to identify granuloma-enriched T cell genes.
    [Journal of Experimental Medicine]

    Abstract

    T Helper 1 Effector Memory CD4+ T Cells Protect the Skin from Poxvirus Infection

    The authors showed that T helper 1 memory CD4+ T cells were necessary and sufficient to provide complete and broad protection against poxvirus skin infections.
    [Cell Reports]

    Full ArticleGraphical Abstract

    The Evolution of Colistin Resistance Increases Bacterial Resistance to Host Antimicrobial Peptides and Virulence

    Scientists showed that mobile colistin resistance provided a selective advantage to Escherichia coli in the presence of key antimicrobial peptides (AMPs) from humans and agricultural animals by increasing AMP resistance.
    [eLife]

    Full ArticlePress Release
    How can evaluating the immuno-oncology potential of compounds in vitro predict clinical outcomes? Watch this webinar by Dr. Alison O'Mahony, Eurofins DiscoverX
    REVIEWS

    Cell Entry and Release of Quasi-Enveloped Human Hepatitis Viruses

    Investigators discuss the mechanisms by which specific peptide sequences in the capsids of quasi-enveloped virions mediate their endosomal sorting complexes required for transport-dependent release from hepatocytes through multivesicular endosomes.
    [Nature Reviews Microbiology]

    Full Article
    INDUSTRY AND POLICY NEWS

    Atea Pharmaceuticals Announces US FDA Fast Track Designation Granted to Bemnifosbuvir, an Investigational Oral Antiviral, for the Treatment of COVID-19

    Atea Pharmaceuticals, Inc. announced that the US FDA has granted Fast Track designation to bemnifosbuvir, an oral direct-acting antiviral drug candidate, for the global Phase III SUNRISE-3 registrational trial for the treatment of COVID-19.
    [Atea Pharmaceuticals, Inc.]

    Press Release

    As Federal Emergency Declaration Expires, the Picture of the Pandemic Grows Fuzzier

    The federal government’s public health emergency that’s been in effect since January 2020 is set to expire on May 11. Public health legal scholars, data experts, federal officials, and patients at high risk of severe covid outcomes worry the scaling back of data access could make it harder to control covid.
    [KFF Health News]

    Press Release
    FEATURED EVENT

    The Aging Genome: From Mechanisms to Disease

    June 4 – 7, 2023
    Heidelberg, Germany

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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Infectious Diseases

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Research Fellow – Infection and Immunity

    The University of Southern California – Los Angeles, California, United States

    Postdoctoral Position – Neural-Immune Interaction

    National Institutes of Health – Bethesda, Maryland, United States

    Postdoctoral Fellowship – Autophagy in Viral Infection

    Umeå University – Umeå, Sweden

    Research Professor – Virus Ecology

    Institute of Tropical Medicine – Antwerp, Belgium

    > See All Jobs

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