Immunology of Infectious Disease News Volume 11.17 | May 3 2023

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    2023-05-03 | IIDN 11.17


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.17 – 3 May, 2023
    TOP STORY

    Monkeypox Virus Quadrivalent mRNA Vaccine Induces Immune Response and Protects against Vaccinia Virus

    The authors developed two monkeypox virus quadrivalent mRNA vaccines, named mRNA-A-LNP and mRNA-B-LNP, based on two intracellular mature virus-specific proteins, A29L and M1R, and two extracellular enveloped virus-specific proteins, A35R and B6R.
    [Signal Transduction and Targeted Therapy]

    Full Article
    Studying COVID-19 with ALI culture
    PUBLICATIONSRanked by the impact factor of the journal

    Human Memory B Cells Show Plasticity and Adopt Multiple Fates upon Recall Response to SARS-CoV-2

    Researchers showed that single severe acute respiratory syndrome coronavirus 2-specific memory B cell clones showed plasticity upon antigen rechallenge in previously exposed individuals.
    [Nature Immunology]

    Full Article

    The SARS-CoV-2 Papain-Like Protease Suppresses Type I Interferon Responses by Deubiquitinating STING

    Scientists investigated the mechanism by which the SARS-CoV-2 papain-like protease (PLpro) antagonizes cellular antiviral response and revealed how SARS-CoV-2 PLpro inhibited type I interferon signaling through stimulator of interferon genes (STING) deubiquitination.
    [Science Signaling]

    Full Article

    A Recombinant Spike-XBB.1.5 Protein Vaccine Induces Broad-Spectrum Immune Responses against XBB.1.5-included Omicron Variants of SARS-CoV-2

    Investigators evaluated and compared the immune responses induced by six different spike protein vaccines targeting the ancestral or various Omicron strains of SARS-CoV-2 in mice.
    [MedComm]

    Full Article

    Single-Cell RNA Sequencing Reveals the Fragility of Male Spermatogenic Cells to Zika Virus-Induced Complement Activation

    Scientists performed single-cell RNA sequencing using testes from Zika virus (ZIKV)-infected mice to address the mechanisms underlying ZIKV’s influence on male reproductive health during an infection.
    [Nature Communications]

    Full Article

    Innate Immune Pathway Modulator Screen Identifies STING Pathway Activation as a Strategy to Inhibit Multiple Families of Arbo and Respiratory Viruses

    Investigators observed that Toll-like receptor 3 (TLR3), stimulator of interferon genes (STING), TLR8, and Dectin-1 ligands inhibited arboviruses, Chikungunya virus, West Nile virus, and Zika virus to varying degrees.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Intrinsic B Cell TLR-BCR Linked Coengagement Induces Class-Switched, Hypermutated, Neutralizing Antibody Responses in Absence of T Cells

    Researchers showed that B cell Toll-like receptor 4 (TLR4)–B cell receptor (BCR) coengagement by 4-hydroxy-3-nitrophenyl acetyl (NP)–lipopolysaccharide or TLR5-BCR coengagement by Salmonella flagellin induced mature antibody responses to NP and flagellin in Tcrβ−/−Tcrδ−/− and NSG/B mice.
    [Science Advances]

    Full Article

    Improvement of B Cell Responses by An HIV-1 Amphiphilic Polymer Nanovaccine

    Investigators designed a new HIV-1 envelope glycoprotein nanoparticle (Env/NP) vaccine using amphiphilic polymers. The Env/NP vaccine induced more potent and broader neutralizing activities against multiple HIV-1 subtypes.
    [Nano Letters]

    Full ArticleGraphical Abstract

    Alphavirus Infection Triggers Antiviral RNAi Immunity in Mammals

    Scientists found that a wild-type alphavirus, Semliki Forest virus, triggered the Dicer-dependent production of virus-derived small interfering RNAs in both mammalian somatic cells and adult mice.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Activate, expand, and differentiate your cells with cytokines, chemokines, and growth factors from STEMCELL Technologies.
    REVIEWS

    Role of CXCR5+ CD8+ T Cells in Human Hepatitis B Virus Infection

    The authors focus on the function of CXCR5+CD8+ T cells in hepatitis B virus (HBV) infection and discuss the function of these CD8+ T cells and the potential of associated co-stimulators or cytokines in HBV therapeutic strategies.
    [Journal Of Viral Hepatitis]

    Abstract
    INDUSTRY AND POLICY NEWS

    FDA Approves First Respiratory Syncytial Virus (RSV) Vaccine

    The US FDA approved Arexvy, the first RSV vaccine approved for use in the United States. Arexvy is approved for the prevention of lower respiratory tract disease caused by RSV in individuals 60 years of age and older.
    [FDA]

    Press Release

    $165-Million for McGill University’s World-Leading Inclusive Genomics and RNA Research Program

    The Minister of Innovation, Science and Industry, announced $1.4 billion in support of 11 large-scale research initiatives through the Canada First Research Excellence Fund (CFREF). McGill is the recipient of a landmark $165 million CFREF grant.
    [McGill University]

    Press Release
    FEATURED EVENT

    Cell Symposia: Infection Biology in the Age of the Microbiome

    June 7 – 9, 2023
    Paris, France

    > See All Events

    JOB OPPORTUNITIES

    Associate Professor – Vaccine Informatics

    Nagasaki University – Nagasaki, Japan

    Research Associate – Virology

    Baylor College of Medicine – Houston, Texas, United States

    Postdoctoral Research Associate – Infectious Diseases

    St. Jude Children’s Research Hospital – Memphis, Tennessee, United States

    Postdoctoral Research Fellow – Infection and Immunity

    The University of Southern California – Los Angeles, California, United States

    Postdoctoral Position – Neural-Immune Interaction

    National Institutes of Health – Bethesda, Maryland, United States

    > See All Jobs

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