 | | Vol. 11.18 – 10 May, 2023 |
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| Based on identification of the T cell receptor repertoire and functionality landscape of naive epitope-specific CD8+ T cells, researchers reconstructed defined repertoires that could be followed as polyclonal populations during immune responses in vivo.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Deep immune profiling using single-cell RNA and repertoire sequencing of peripheral blood mononuclear cells during acute disease revealed expansion of activated CXCR3+ cytotoxic T cells and natural killer cells, both phenotypically resembling cytokine-driven killer cells.
[Science Immunology] |
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| Scientists conducted a daily longitudinal exact one-to-one matching study based on a set of covariates. They obtained a matched sample of 315,650 individuals aged 18–70 years who received the 3rd dose at 20–30 weeks after the 2nd dose and an equally large control group who did not.
[BMC Medicine] |
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| A comprehensive panel of 63 biomarkers was measured in repeated bronchoalveolar lavage fluid and plasma samples of patients with COVID-19 acute respiratory distress syndrome.
[Thorax] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Investigators applied two assays to quantify neutralizing antibody (NAbs) in sera from control, Mpox virus (MPXV)-infected or Modified Vaccinia Ankara (MVA)-vaccinated individuals. Various levels of MVA NAbs were detected after infection, historic smallpox, or recent MVA vaccination.
[Cell Host & Microbe] |
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| Scientists showed that s.c. Bacillus Calmette-Guérin vaccine-induced trained innate immunity provided enhanced heterologous innate protection against pulmonary Streptococcus pneumoniae infection.
[EMBO Molecular Medicine] |
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| Treatment of HIV-1ADA-infected CD34+ NSG-humanized mice with long-acting ester prodrugs of cabotegravir, lamivudine, and abacavir in combination with native rilpivirine was followed by dual CRISPR-Cas9 C-C chemokine receptor type five (CCR5) and HIV-1 proviral DNA gene editing.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Scientists showed that the induction of non-canonical proinflammatory-prone M2 (M2INF) macrophages by IL-4 intraperitoneal injection and transferring of M2INF macrophages conferred a survival advantage against bacterial infection in vivo.
[Cell Reports] |
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| A single dose of an expression-optimized version of a H107 vaccine candidate/CAF®01 adjuvant with Bacillus Calmette-Guérin (BCG) induced long-lived immunity and triggered BCG-specific T helper 17 cell responses.
[NPJ Vaccines] |
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| Within HIV-1-infected individuals, Schlafen 12 protein (SLFN12) expression in peripheral blood mononuclear cells correlated with HIV-1 plasma viral loads and proviral loads, suggesting a link with the general activation of the immune system.
[Communications Biology] |
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| The authors provide an overview of recurrent Clostridioides difficile infection pathogenesis, followed by a discussion of potential mechanisms of action focusing on the current understanding of trans-kingdom microbial, metabolic, immunological, and epigenetic mechanisms.
[Cell Host & Microbe] |
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| Scientists highlight the development of COVID-19 therapies and the challenges that remain for anticoronavirals.
[Nature Microbiology] |
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| The World Health Organization said that COVID-19 no longer qualifies as a global emergency, marking a symbolic end to the devastating coronavirus pandemic that triggered once-unthinkable lockdowns, upended economies, and killed millions of people worldwide.
[AP News] |
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| The new four-year grant is a stripped-down version of the original grant to the EcoHealth Alliance. That 2014 award included funding for controversial experiments that mixed parts of different bat viruses related to severe acute respiratory syndrome, and included a subaward to the Wuhan Institute of Virology. The new award omits those studies, and also imposes extensive new accounting rules on EcoHealth, which drew criticism from government auditors for its bookkeeping practices.
[Science Insider] |
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| June 6 – 10, 2023
Keystone, Colorado, United States |
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| | Rutgers University – New Brunswick, New Jersey, United States |
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| | University of Western Australia – Perth, Australia |
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| | Calico Life Sciences LLC – San Francisco, California, United States |
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| | Ume̴ University РUme̴, Sweden |
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| | National Health Research Institutes – Zhunan, Taiwan |
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