Immunology of Infectious Disease News Volume 11.19 | May 17 2023

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    2023-05-17 | IIDN 11.19


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.19 – 17 May, 2023
    TOP STORY

    Multi-Dimensional Dissection of Blood Components Reveals an Uncanonical Immune Landscape in SARS-CoV-2 Omicron Patients

    Using in-depth integrated multi-omics, researchers dissected the host response dynamics during multiple disease phases to reveal the molecular and cellular landscapes in the blood.
    [Immunity]

    Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Efficacy of mRNA-1273 and Novavax Ancestral or BA.1 Spike Booster Vaccines against SARS-CoV-2 BA.5 Infection in Non-Human Primates

    Investigators compared the efficacy of three booster vaccines against Omicron BA.5 challenge in rhesus macaques: mRNA-1273, the Novavax ancestral spike protein vaccine, or Omicron BA.1 spike protein version.
    [Science Immunology]

    Full Article

    Evolution of Antibody Immunity following Omicron BA.1 Breakthrough Infection

    Researchers tracked SARS-CoV-2 receptor binding domain-specific antibody responses up to six months following Omicron BA.1 breakthrough infection in six mRNA-vaccinated individuals.
    [Nature Communications]

    Full Article

    A Computationally Designed ACE2 Decoy Has Broad Efficacy against SARS-CoV-2 Omicron Variants and Related Viruses In Vitro and In Vivo

    Using a computational design strategy, investigators designed an affinity-enhanced ACE2 decoy, FLIF, that exhibited tight binding to SARS-CoV-2 delta and omicron variants.
    [Communications Biology]

    Full Article

    Molecular Basis of SARS-CoV-2 Omicron Variant Evasion from Shared Neutralizing Antibody Response

    Structural analysis of these monoclonal antibodies (mAbs) in complex with trimeric spike protein showed that all three mAbs bivalently bind spike with two mAbs targeting class 1 and one targeting a class 4 receptor binding domain epitope.
    [Structure]

    Full ArticleGraphical Abstract

    Transcriptional Programming of CD4+ TRM Differentiation in Viral Infection Balances Effector- and Memory-Associated Gene Expression

    Researchers investigated the phenotypic, functional, and transcriptional profiles of CD4+ tissue-resident memory T cells in the small intestine responding to acute viral infection, revealing a shared gene expression program and chromatin accessibility profile with circulating TH1.
    [Science Immunology]

    Abstract

    Intercellular Communication within the Virus Microenvironment Affects the Susceptibility of Cells to Secondary Viral Infections

    Scientists showed that human cytomegalovirus (HCMV) infection primed neighboring cells for both subsequent HCMV infections and secondary infections with herpes simplex virus 1 and influenza A.
    [Science Advances]

    Full Article

    Human Papillomavirus E5 Suppresses Immunity via Inhibition of the Immunoproteasome and STING Pathway

    The authors demonstrated that human papillomavirus E5 was a negative regulator of anti-viral interferon response pathways, antigen processing, and antigen presentation.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Zika Virus Infection Induces Interleukin-1β-Mediated Inflammatory Responses by Macrophages in the Brain of an Adult Mouse Model

    Investigators used an adult Zika virus infection mouse model, Ifnar1−/−, to investigate the mechanisms underlying neuroinflammation and neuropathogenesis.
    [Journal of Virology]

    Full Article
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    REVIEWS

    Targetable Elements in SARS-CoV-2 S2 Subunit for the Design of Pan-Coronavirus Fusion Inhibitors and Vaccines

    Scientists summarize the most recently developed broad-spectrum fusion inhibitors, such as neutralizing antibodies, peptides, proteins, small-molecule compounds, and candidate vaccines targeting the conserved elements in the SARS-CoV-2 S2 subunit.
    [Signal Transduction And Targeted Therapy]

    Full Article
    INDUSTRY AND POLICY NEWS

    ‘The Disease Will Be Neglected’: Scientists React to the WHO Ending Mpox Emergency

    The World Health Organization (WHO) announced that mpox was no longer a public health emergency of international concern — but researchers fear that the decision will draw critical resources away from curbing the disease, which is still prevalent in regions including Africa.
    [Nature]

    Press Release
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Postdoctoral Research Associate – Host-Virus Interaction

    Brown University – Providence, Rhode Island, United States

    Postdoctoral Fellow – Viral Infections and Cancers

    UMass Chan Medical School – Worcester, Massachusetts, United States

    Postdoctoral Fellow – Neural-Immune Interactions

    National Institutes of Health – Bethesda, Maryland, United States

    Research Associate – Antibody and T Cell Responses

    Rutgers University – New Brunswick, New Jersey, United States

    Postdoctoral Fellow – Viral Infections and Cancers

    UMass Chan Medical School – Worcester, Massachusetts, United States

    > See All Jobs

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