 | | Vol. 11.20 – 24 May, 2023 |
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| Investigators identified transcription of complement system genes as the top biological pathway induced in candidemic patients and as predictive of candidemia.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors developed a lipid nanoparticle-formulated mRNA-based T cell-inducing antigen, which targeted three SARS-CoV-2 proteome regions that enriched human HLA-I epitopes.
[Nature Communications] |
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| Researchers elucidated mechanisms of the altered infectivity associated with the Omicron variants. They systemically evaluated mutations located in the S2 sequence of spike and identified mutations that were responsible for altered viral fusion.
[Communications Biology] |
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| Scientists analyzed the clonal basis of the rapid T cell response following SARS-COV-2 infection and applied T cell receptor sequencing to define the trajectories of individual T cell clones immediately.
[iScience] |
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| The authors evaluated the antiviral activity of 2-pyridone PIM1 inhibitor against SARS-CoV-2 and its potential role in hindering the progression of COVID-19.
[The Journal Of Genetic Engineering And Biotechnology] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Scientists investigated functionality, clonotypic compartmentalization, spatial localization, phenotypic characteristics, and transcriptional profiles of lymph node-resident virus-specific CD8+ T cells in persons who control HIV without medications.
[Science Immunology] |
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| Genetic gain-of-function and loss-of-function experiments, as well as in vitro and in vivo chemical inhibition, confirmed the functional involvement of transferrin receptor 1 in influenza A virus entry.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors demonstrated the concerted inhibition of different influenza A virus strains using a low-molecular-weight dual-action linear polymer.
[Nano Letters] |
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| Functional HIV-1 virus persists in CD4+ T cell subsets in non-peripheral compartments that were not easily accessible. Scientists investigated tissue-homing properties of cells that transiently appear in the circulating blood.
[Cell Reports Methods] |
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| Researchers determined that honokiol protected Vero E6 cells from SARS-CoV-2-mediated cytopathic effect, with a 50% effective concentration of 7.8 μM.
[Microbiology Spectrum] |
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| Scientists discuss how the susceptibility to many parasite infections is controlled by regulatory T cells, and the role they play in moderating the immunopathological consequences of parasitism, and dampening bystander reactions in an antigen-nonspecific manner.
[Trends in Parasitology] |
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| Investigators summarize T cell immunity in common Epstein–Barr virus (EBV)-associated diseases in children, including infectious mononucleosis, chronic active EBV infection and EBV-associated hemophagocytic lymphohistiocytosis.
[Infection Genetics And Evolution] |
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| Drs. Alyson Kelvin and Angela Rasmussen from the University of Saskatchewan’s Vaccine and Infectious Disease Organization (VIDO) have received $1 million in total funding to study mpox from the Canadian Institutes of Health Research.
[University of Saskatchewan] |
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| June 15 – 19, 2023
Houston, Texas, United States |
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| | National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States |
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| | Texas A&M University – College Station, Texas, United States |
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| | Brown University – Providence, Rhode Island, United States |
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| | UMass Chan Medical School – Worcester, Massachusetts, United States |
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| | National Institutes of Health – Bethesda, Maryland, United States |
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