 | | Vol. 11.21 – 31 May, 2023 |
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| The authors conducted a case–control study based on data from Cosmos, a nationwide Epic electronic health record database, to assess the effectiveness of JYNNEOS vaccination in preventing medically attended mpox disease among adults.
[New England Journal Of Medicine] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers profiled the clinical phenomes, transcriptomes, proteomes, metabolomes, and immune repertoires of >1,000 blood cell or plasma specimens from SARS-CoV-2 Omicron patients.
[Immunity] |
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| Reduced receptor-binding domain antibodies, spike-specific B cell,s and follicular helper T cells were found in vaccinated participants with chronic conditions and were strongly associated with altered glycosylation of IgG and increased interleukin-18 levels in the plasma.
[Nature Immunology] |
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| The authors demonstrated that upon phagocytosis of SARS-CoV-2-infected cells, monocyte-derived macrophages were activated and secreted IL-6 and TNF.
[Cellular & Molecular Immunology] |
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| Scientists identified inter-variant differences in timing and magnitude of infectious particle shedding from index mice, both of which shaped transmission to contact mice.
[Nature Communications] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| To define how allogeneic hematopoietic stem cell transplantation (alloHSCT) mediates HIV cure, the authors performed MHC-matched alloHSCT in SIV+, anti-retroviral therapy (ART)-suppressed Mauritian cynomolgus macaques.
[Immunity] |
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| Investigators interrogated IFN-stimulated genes (ISGs) restriction of primary HIV in CD4+ T cells by performing CRISPR-knockout screens with a custom library that specifically targeted ISGs expressed in CD4+ T cells.
[Cell Reports] |
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| Two mRNA vaccines encoding PcrV– the key component of the type III secretion system in Pseudomonas and the fusion protein OprF-I comprising outer membrane proteins OprF and OprI were constructed.
[NPJ Vaccines] |
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| Bacteria-instructed B cells rapidly degraded phagocytosed bacteria, processed bacterial antigens and cross-primeed naïve CD8+ T cells which differentiated into specific cytotoxic cells that efficiently controlled bacterial infections.
[EMBO Reports] |
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| The authors review how regulatory T cellsmaintain the delicate balance between tolerance, immunity, and pathology in infection.
[Trends In Parasitology] |
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| French medical bodies called on authorities to punish researcher Didier Raoult for “the largest ‘unauthorised’ clinical trial ever seen” into the use of hydroxychloroquine to treat Covid-19.
[France 24] |
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| Troubled by side effect data from Pfizer’s trials and by another big drugmaker’s abandonment of a similar vaccine given during pregnancy, the panel split on the question of the vaccine’s safety, with multiple members concerned that it may increase the rate of premature births.
[Science Insider] |
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| Developing more broadly protective products requires comparisons with existing shots that Pfizer and Moderna won’t allow.
[Science Insider] |
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| July 17 – 20, 2023
Burlington, Vermont, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Texas A&M University – College Station, Texas, United States |
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| | National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States |
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| | Brown University – Providence, Rhode Island, United States |
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| | Nagasaki University – Nagasaki, Japan |
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