Immunology of Infectious Disease News Volume 11.22 | Jun 7 2023

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    2023-06-07 | IIDN 11.22


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.22 – 7 June, 2023
    TOP STORY

    Platelets and Mast Cells Promote Pathogenic Eosinophil Recruitment during Invasive Fungal Infection via the 5-HIAA-GPR35 Ligand-Receptor System

    Given the inflammatory nature of the cryptococcal infection, the authors examined the role of GPR35 in the circuitry underlying cell recruitment to the lung.
    [Immunity]

    Full ArticleGraphical Abstract
    Resources for Your T Cell Therapy Research
    PUBLICATIONSRanked by the impact factor of the journal

    Hamster Model for Post-COVID-19 Alveolar Regeneration Offers an Opportunity to Understand Post-Acute Sequelae of SARS-CoV-2

    Investigators demonstrated that CK8+ alveolar differentiation intermediate cells occured following SARS-CoV-2-induced diffuse alveolar damage.
    [Nature Communications]

    Full Article

    Inhibition of SARS-CoV-2-Mediated Thromboinflammation by CLEC2.Fc

    Scientists found that the spleen tyrosine kinase-coupled C-type lectin member 2 (CLEC2), which was highly expressed in platelets and alveolar macrophages, interacted with the receptor-binding domain of SARS-CoV-2 spike protein directly.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Antiviral Effect of SARS-CoV-2 N-specific CD8+ T Cells Induced in Lungs by Engineered Extracellular Vesicles

    The authors investigated the immunity generated in the lungs by N-engineered extracellular vesicles in terms of induction of N-specific effectors and resident memory CD8+ T lymphocytes before and after virus challenge before and after virus challenge carried out three weeks and three months after boosting.
    [NPJ Vaccines]

    Full Article

    Generation of Host-Directed and Virus-Specific Antivirals Using Targeted Protein Degradation Promoted by Small Molecules and Viral RNA Mimics

    Scientists applied proteolysis-targeting chimera approaches to develop broad-spectrum antivirals targeting key host factors for many viruses and virus-specific antivirals targeting unique viral proteins.
    [Cell Host & Microbe]

    AbstractGraphical Abstract

    Tissue-Resident Memory T Cells Mediate Mucosal Immunity to Recurrent Urinary Tract Infection

    Researchers found that reducing bacterial load early in infection, by reducing the inoculum or with antibiotics after infection, completely abrogated the protective memory response of tissue resident memory T cells.
    [Science Immunology]

    AbstractPress Release

    The E3 Ligase HERC5 Promotes Antimycobacterial Responses in Macrophages by ISGylating the Phosphatase PTEN

    Investigators explored the role of ISGylation in the macrophage response to infection with Mycobacterium tuberculosis.
    [Science Signaling]

    Full Article

    Differential Localization of Dengue Virus Protease Affects Cell Homeostasis and Triggers to Thrombocytopenia

    Scientists showed the differential localization of existing two forms of dengue virus protease i.e., NS2BNS3 to the nucleus and NS3 to the nucleus and mitochondria.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Differing Natural Killer Cell, T Cell, and Antibody Profiles in Antiretroviral-Naive HIV-1 Viraemic Controllers with and without Protective HLA Alleles

    Researchers aimed to gain insight into potential mechanisms of control in protective human leukocyte antigen class I alleles (VC+) and controllers without protective alleles (VC-). They studied 15 VC+, 12 VC- and four healthy uninfected individuals.
    [PLOS One]

    Full Article
    Explore this validated protocol for high-efficiency CRISPR-Cas9 gene editing of Human Primary T Cells.
    REVIEWS

    SARS-CoV-2 and the Nervous System: Current Perspectives

    The authors discuss literature focusing on clinical observations that suggest associations between SARS-CoV-2 infection and the nervous system.
    [Archives of Virology]

    Full Article
    INDUSTRY AND POLICY NEWS

    U of L Receives Grants for COVID-19 Research

    Researchers at the University of Louisville (U of L) have received federal grants totaling over $6 million for their work in understanding and preventing a serious complication that appears in some COVID-19 patients.
    [Kentucky Today]

    Press Release

    China’s Rolling COVID Waves Could Hit Every Six Months — Infecting Millions

    The latest surge is unlikely to crash the country’s healthcare system, but scientists fear hundreds of millions of infections.
    [Nature]

    Editorial
    FEATURED EVENT

    AACR-AHNS Head and Neck Cancer Conference: Innovating through Basic, Clinical, and Translational Research

    July 7 – 8, 2023
    Montréal, Québec, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellow – Immunologist Studying Models of Infectious Diseases

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Scientist – Opportunistic Fungal Infections

    Cedars-Sinai – Los Angeles, California, United States

    Postdoctoral Position – Mitochondria and Innate Immunity

    Texas A&M University – College Station, Texas, United States

    Postdoctoral Intramural Research Fellowship Position – Orthobunyaviruses

    National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States

    Postdoctoral Research Associate – Host-Virus Interaction

    Brown University – Providence, Rhode Island, United States

    > See All Jobs

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