 | | Vol. 11.23 – 14 June, 2023 |
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| Researchers showed that the mRNA vaccine BNT162b2 induced robust protective immunity in K18- human angiotensin-converting enzyme 2 transgenic B cell-deficient mice.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists reported an inducible, transgenic human angiotensin–converting enzyme II (hACE2) mouse line and showcased three examples for specifically expressing hACE2 in three different lung epithelial cells.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Leveraging the golden hamster model of COVID-19, researchers elucidated the dynamics between SARS-CoV-2 infection in the airways and the systemic host response that ensues.
[Science Signaling] |
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| Investigators found that the human coronaviruses HCoV-OC43, human coronavirus OC43, and SARS-CoV-2 both robustly activated the IRE1α–XBP1 branch of the unfolded protein response in cultured cells.
[mBio] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| The authors discovered an important mechanism for blood–brain barrier disruption that was driven by unique features of histidine-rich protein II, a protein secreted by Plasmodium falciparum during the blood stage of malaria infection.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| Using a CRISPR screen, investigators identified that murine cytomegalovirus (MCMV)-encoded chemokine 2 (MCK2)-dependent infection required MHC class Ia/β-2-microglobulin expression.
[Cell Reports] |
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| In single-round vesicular stomatitis virus-G-pseudotyped HIV-1 infection, aryl hydrocarbon receptor blockade increased the efficacy of early/late reverse transcription and subsequently facilitated integration/translation.
[Cell Reports] |
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| Researchers mechanistically investigated the involvement of Hippo signaling in hepatitis B virus surface antigen-dependent neoplastic transformation.
[Liver International] |
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| The authors investigated the effects of capsaicin on viral replication and innate antiviral immune response and discovered that capsaicin dose-dependently inhibited the replication of VSV, EMCV, and H1N1.
[Acta Pharmacologica Sinica] |
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| Scientists review the protective immune responses elicited by both B. bronchiseptica and B. pertussis and explore their pathogenesis and vaccine treatment considerations.
[Clinical Microbiology Reviews] |
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| Fred Hutch announced that Daniel Blanco-Melo, PhD and Lillian Cohn, PhD were the latest Fred Hutch scientists to benefit from highly competitive grant programs, which give a financial boost to promising, early-career scientists.
[Fred Hutchinson Cancer Center] |
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| August 1 – 2, 2023
Seattle, Washington, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Howard Hughes Medical Institute – Ashburn, Virginia, United States |
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| | University Hospital Ulm – Ulm, Germany |
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| | Texas A&M University – College Station, Texas, United States |
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| | National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States |
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