 | | Vol. 11.24 – 21 June, 2023 |
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| Scientists collected serum and nasal swab samples from 108 participants who had been infected during the BA.5 infection wave, and evaluated the neutralization against pseudoviruses.
[Signal Transduction and Targeted Therapy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators described a third antiviral modality that combined the drug-like advantages of antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection.
[Nature Communications] |
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| To address the need for reliable anti-coronavirus therapeutics, the authors screened 16 active phytochemicals selected from medicinal plants used in traditional applications for respiratory-related illnesses.
[International Journal of Antimicrobial Agents] |
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| Scientists showed that the ORF3c protein had a mitochondrial localization and altered mitochondrial metabolism, inducing a shift from glucose to fatty acids oxidation, and enhanced oxidative phosphorylation.
[iScience] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers designed and implemented a stringent clinical surveillance protocol to longitudinally track both viral shedding and in situ tissue immune responses in a cohort of herpes simplex virus+ volunteers.
[Journal of Experimental Medicine] |
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| The authors showed that temperature-dependent epistatic interactions between phosphodiesterases counterbalance guanylyl cyclase α basal activity preventing gametocyte activation before mosquito blood feed.
[Science Advances] |
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| Investigators exposed how the influenza virus capitalized on host-derived interferon-induced, microRNA-193b-5p to target occludin and compromise antiviral defenses.
[Molecular Therapy] |
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| Scientists explored outer membrane vesicle (OMV) alterations of mobile colistin resistance 1 (MCR-1)-carrying bacteria in the presence and absence of sub-MIC MSI-1, and host immune activation during bacterial infection and OMV stimulation.
[Microbial Biotechnology] |
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| Researchers analyzed the miRNA profiles of non-infected human red blood cells (RBCs), ring-infected RBCs, and trophozoite-infected RBCs, as well as those of extracellular vesicles secreted from these cells.
[iScience] |
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| The authors investigated the antiviral efficacy of β-escin on Zika virus and dengue virus in vitro and then elucidated the underlying mechanism.
[Scientific Reports] |
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| Investigators amalgamate contemporary understanding concerning antibodies targeting various regions, including receptor-binding domain (RBD), non-RBD, host cell targets, and cross-neutralising antibodies.
[Reviews In Medical Virology] |
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| Scientists perform a narrative review of the molecular connection between macroautophagy and Zika virus infection while focusing on the roles of the structural and nonstructural proteins.
[Journal Of Cellular Biochemistry] |
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| Negotiators met to discuss the latest draft of a ‘pandemic treaty’ — an agreement among countries worldwide about how to best respond to the next massive outbreak.
[Nature] |
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| Integral Molecular announced that the Commonwealth of Pennsylvania has awarded the company $1M of funding through the Redevelopment Assistance Capital Program that will be used to support the further expansion of the company’s new headquarters and buildout of its Pandemic Research Center.
[Integral Molecular, Inc.] |
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| August 28 – 30, 2023
Santa Fe, New Mexico, United States |
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| | University of Miami – Miami, Florida, United States |
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| | Case Western Reserve University – Cleveland, Ohio, United States |
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| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | University Hospital Ulm – Ulm, Germany |
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| | Howard Hughes Medical Institute – Ashburn, Virginia, United States |
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