 | | Vol. 11.26 – 5 July, 2023 |
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| Scientists demonstrated that the cellular metabolite flavin adenine dinucleotide (FAD) was used as a non-canonical initiating nucleotide by the viral RNA-dependent RNA polymerase, resulting in a 5′-FAD cap on the hepatitis C virus RNA.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors hypothesized that the T492I mutation increases viral transmissibility and adaptability, which they confirmed with competition experiments in hamster and human airway tissue culture models.
[Cell Host & Microbe] |
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| In the large prospective ENFORCE cohort, investigators quantified spike-specific antibodies to five omicron variants, BA.1 to BA.5, before and after BA.1 or BA.4/5 bivalent booster vaccination to compare omicron variant-specific antibody inductions.
[Clinical Infectious Diseases] |
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| Researchers demonstrated that exposure of mice to the high ambient temperature of 36 °C increased host resistance to viral pathogens including influenza virus and SARS-CoV-2. High heat-exposed mice increase basal body temperature over 38 °C to enabled more bile acids production in a gut microbiota-dependent manner.
[Nature Communications] |
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| The authors evaluated a natural killer T cell-stimulatory agent for respiratory virus infections. They reported on a glycolipid termed 7DW8-5 that exploited the host innate immune system to enable rapid control of viral infections in vivo.
[Nature Communications] |
| | MORE IMMUNOLOGY OF INFECTIOUS DISEASE |
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| Researchers conducted a prospective clinical trial with two HIV-1 broadly neutralizing antibodies in children who had previously initiated small-molecule antiretroviral treatment treatment before seven days of age and who continued treatment for at least 96 weeks.
[Science Translational Medicine] |
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| In mice, intraperitoneal administration of the caspase-8 inhibitor z-IETD-fmk was sufficient to unleash the production of pro-inflammatory cytokines and neutrophil influx in the absence of cell death.
[Cell Reports Medicine] |
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| To identify factors that may limit sexual CXCR4-tropic (X4)-HIV-1 transmission, scientists generated a seminal fluid–derived compound library and screened it for antiviral agents. They determined that seminal spermine restricted sexual X4-HIV-1 transmission.
[Science Advances] |
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| Investigators found that cynomolgus macaques, Macaca fascicularis, inoculated with Zika virus (ZIKV) or Spondweni virus (SPONV) were susceptible to ZIKV but resistant to SPONV infection.
[Science Advances] |
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| Scientists demonstrated that pharmacological inhibition or depletion of neutral sphingomyelinase 2 in HIV-1-producer cells resulted in a block in the processing of the major viral structural polyprotein Gag and the production of morphologically aberrant, immature HIV-1 particles with severely impaired infectivity.
[Proceedings Of The National Academy Of Sciences Of The United States Of America] |
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| The authors report the vital clinical observations of SARS-CoV-2 infection or vaccination in cancer patients treated with immune checkpoint inhibitors and explore the potential interaction between them.
[Cell Death & Disease] |
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| Three University Hospitals and Case Western Reserve University School of Medicine research teams recently received Collaborative Science Pilot Awards. The teams each received $50,000, funded by both institutions.
[Case Western University] |
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| September 13 – 15, 2023
Seogwipo, South Korea |
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| | National University of Singapore – Singapore, Singapore |
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| | Maynooth University – Maynooth, Ireland |
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| | National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | University of Miami – Miami, Florida, United States |
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