Immunology of Infectious Disease News Volume 11.27 | Jul 12 2023

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    2023-07-12 | IIDN 11.27


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.27 – 12 July, 2023
    TOP STORY

    Anti-V1/V3-Glycan Broadly HIV-1 Neutralizing Antibodies in a Post-Treatment Controller

    Scientists described a broadly neutralizing antibody B cell lineage elicited in a post-treatment controller that exhibited broad seroneutralization and showed that a representative antibody from this lineage targeted a quaternary epitope in the glycan-V3 loop supersite of the HIV-1 envelope glycoprotein.
    [Cell Host & Microbe]

    AbstractGraphical Abstract
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    PUBLICATIONSRanked by the impact factor of the journal

    IL-9 Aggravates SARS-CoV-2 Infection and Exacerbates Associated Airway Inflammation

    The authors showed, in a K18-hACE2 transgenic mouse model, that IL-9 contributed to and exacerbated viral spread and airway inflammation caused by SARS-CoV-2 infection.
    [Nature Communications]

    Full Article

    Smoke and Spike: Benzo[a]pyrene Enhances SARS-CoV-2 Infection by Boosting NR4A2-Induced ACE2 and TMPRSS2 Expression

    Scientists showed that benzopyrene in cigarette smoke extract facilitated SARS-CoV-2 infection via upregulating angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2).
    [Advanced Science]

    Full Article

    Increased Neutralization Potency and Breadth Elicited by a SARS-CoV-2 mRNA Vaccine Forming Virus-Like Particles

    Researchers applied a mRNA forming vaccine virus-like particles (VLPs) platform to SARS-CoV-2 to evaluate potential improvements. To facilitate the assembly of VLPs, they replaced the native cytoplasmic tail of the SARS-CoV-2 Spike protein with that of simian immunodeficiency virus.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Removal of Senescent Cells Reduces the Viral Load and Attenuates Pulmonary and Systemic Inflammation in SARS-CoV-2-Infected, Aged Hamsters

    Scientists determined whether age-associated cellular senescence contributed to the severity of experimental COVID-19.
    [Nature Aging]

    Full Article

    Human FcγRIIIa Activation on Splenic Macrophages Drives Dengue Pathogenesis in Mice

    To investigate the in vivo mechanisms of antibody-mediated dengue pathogenesis, investigators developed a mouse model for dengue disease that recapitulates the unique complexity of human Fcγ receptors (FcγRs).
    [Nature Microbiology]

    Abstract

    YF17D-Vectored Ebola Vaccine Candidate Protects Mice against Lethal Surrogate Ebola and Yellow Fever Virus Challenge

    The authors presented YF-EBO, a live YF17D-vectored dual-target vaccine candidate expressing Ebola virus glycoprotein as protective antigen.
    [NPJ Vaccines]

    Full Article

    Ebola Virus Shed Glycoprotein Is Toxic to Human T, B, and Natural Killer Lymphocytes

    To test the whether shed glycoprotein (GP) induces lymphocyte death, scientists cultured primary human B, NK, or T cells with shed GP in vitro. They found that shed GP dependably decreased B, NK, and T cell viability across donors.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Clinical Significance of B7-H3 Expression in Circulating CD4+CD25high T Cells, CD14+ Monocytes, and Plasma for the Progression of HIV Infection

    To explore the expression and clinical significance of B7-H3 in HIV-infected patients, researchers investigated the B7-H3 expression pattern and the correlation of B7-H3 expression with clinical parameters of HIV-infected patients with different levels of CD4+ T cells.
    [BMC Infectious Diseases]

    Full Article
    Try the New Standard in hPSC Maintenance: mTeSRâ„¢ Plus Medium
    REVIEWS

    The Immunology of Long COVID

    Scientists focus on current thinking about the pathophysiology of long COVID and the evidence for potential underpinning mechanisms.
    [Nature Reviews Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    RSV Vaccine for Older Adults Approved by UK Medicines Regulator

    The UK’s medicines regulator has approved the first vaccine against respiratory syncytial virus (RSV) in older adults.
    [The Guardian]

    Press Release

    Politicians, Scientists Spar over Alleged NIH Cover-Up Using COVID-19 Origin Paper

    Two scientists who are co-authors of a 3-year-old article on the origin of the COVID-19 pandemic faced down Republican lawmakers in what might be the most in-depth discussion ever of a scientific paper in the halls of the US Congress.
    [Science Insider]

    Press Release
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    JOB OPPORTUNITIES

    Faculty Positions – Infectious Diseases

    Cleveland Clinic – Port Saint Lucie, Florida, United States

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    ShanghaiTech University – Shanghai, China

    Postdoctoral Position – Immune Modulation in Cancer and Microbiome

    The Hospital of the University of Munich – Munich, Germany

    Research Assistant – Bioinformatics in Pathogen Genomic

    National University of Singapore – Singapore, Singapore

    Track Investigator – Malaria and Vector Research

    National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States

    > See All Jobs

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