Immunology of Infectious Disease News Volume 11.28 | Jul 19 2023

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    2023-07-19 | IIDN 11.28


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.28 – 19 July, 2023
    TOP STORY

    PLSCR1 Is a Cell-Autonomous Defence Factor against SARS-CoV-2 Infection

    Researchers identified phospholipid scramblase 1 (PLSCR1) as a potent cell-autonomous restriction factor against live SARS-CoV-2 infection in parallel genome-wide CRISPR–Cas9 screens of human lung epithelia and hepatocytes.
    [Nature]

    AbstractPress Release
    She wanted to join the battle against cancer. So she started a company. Read Sofie Pattijn's story.
    PUBLICATIONSRanked by the impact factor of the journal

    A Placental Model of SARS-CoV-2 Infection Reveals ACE2-Dependent Susceptibility and Differentiation Impairment in Syncytiotrophoblasts

    To better understand the pathophysiological mechanisms underpinning SARS-CoV-2 infection during placentation, scientists used induced trophoblast stem cells to generate an in vitro early placenta infection model.
    [Nature Cell Biology]

    Full ArticlePress Release

    Picolinic Acid Is a Broad-Spectrum Inhibitor of Enveloped Virus Entry That Restricts SARS-CoV-2 and Influenza a Virus In Vivo

    The authors reported the broad-spectrum antiviral activity of picolinic acid against enveloped viruses, including SARS-CoV-2, influenza A virus, flaviviruses, herpes simplex virus, and parainfluenza virus.
    [Cell Reports Medicine]

    Full ArticleGraphical Abstract

    Proxalutamide Reduces SARS-CoV-2 Infection and Associated Inflammatory Response

    Researchers examined the ability of proxalutamide, an androgen receptor antagonist, to impact SARS-CoV-2 infection and downstream inflammatory responses.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    Effective SARS-CoV-2 Replication of Monolayers of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells

    Scientists proposed utilizing monolayered-intestinal epithelial cells derived from human induced pluripotent stem cells instead of three-dimensional cultured intestinal organoids as a suitable tool to study SARS-CoV-2 infection.
    [Scientific Reports]

    Full Article

    Adenoviral Vectors Infect B Lymphocytes In Vivo

    Investigators demonstrated that engineered Adenoviral vectors were capable of efficiently transducing murine and human primary B cells both ex vivo and in vivo.
    [Molecular Therapy]

    AbstractGraphical Abstract

    The Helicobacter pylori CagA Oncoprotein Disrupts Wnt/PCP Signaling and Promotes Hyperproliferation of Pyloric Gland Base Cells

    Researchers showed that CagA disrupted Wnt-dependent planar cell polarity, which orients cells within the plane of an epithelium and coordinates collective cell behaviors.
    [Science Signaling]

    AbstractPress Release

    HIV-1 Virological Synapse Formation Enhances Infection Spread by Dysregulating Aurora Kinase B

    The authors identified extensive changes in the levels and phosphorylation states of proteins in HIV-1 infected producer cells upon mixing with CD4+ target cells under conditions inducing virological synapse formation.
    [PLOS Pathogens]

    Full Article

    Comparative Proteomics Reveals Cryptosporidium parvum Infection Disrupts Cellular Barriers

    To better understand the molecular mechanism of the interaction between C. parvum and host cells, scientists profiled the changes in host cells’ membrane proteins extracted using native membrane protein extraction kits.
    [Journal of Proteomics]

    AbstractGraphical Abstract
    Breakthroughs take time. Isolating the right cells shouldn't. Learn more.
    REVIEWS

    Respiratory Syncytial Virus Infection and Novel Interventions

    Investigators provide an overview of respiratory syncytial virus (RSV) interventions in clinical development, highlighting global disease burden, seasonality, pathogenesis, and host and viral factors related to RSV immunity.
    [Nature Reviews Microbiology]

    Abstract

    Innate Immunity and Interferon in SARS-CoV-2 Infection Outcome

    The authors sort out the role of innate immunity and complex actions of interferons in the context of SARS-CoV-2 infection and COVID-19.
    [Immunity]

    Full Article
    INDUSTRY AND POLICY NEWS

    FDA Approves Beyfortus™ (Nirsevimab-Alip) to Protect Infants against RSV Disease

    The US FDA has approved Sanofi and AstraZeneca’s Beyfortus™ for the prevention of respiratory syncytial virus (RSV) lower respiratory tract disease in newborns and infants born during or entering their first RSV season.
    [Sanofi]

    Press Release
    FEATURED EVENT

    Vaccinology during and after COVID-19

    September 17 – 19, 2023
    Atlanta, Georgia, United States

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    JOB OPPORTUNITIES

    Postdoctoral Associate – Programmed Cell Death and Viral Infections

    Fox Chase Cancer Center – Philadelphia, Pennsylvania, United States

    Faculty Positions – Infectious Diseases

    Cleveland Clinic – Port Saint Lucie, Florida, United States

    Faculty Positions – Advanced Immunochemical Studies

    ShanghaiTech University – Shanghai, China

    Postdoctoral Position – Immune Modulation in Cancer and Microbiome

    The Hospital of the University of Munich – Munich, Germany

    Research Assistant – Bioinformatics in Pathogen Genomic

    National University of Singapore – Singapore, Singapore

    > See All Jobs

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