Immunology of Infectious Disease News Volume 11.29 | Jul 26 2023

    By
    Bob
    -
    0
    15








    2023-07-26 | IIDN 11.29


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.29 – 26 July, 2023
    TOP STORY

    mRNA Vaccine against Malaria Tailored for Liver-Resident Memory T Cells

    As liver tissue-resident memory T cells (Trm cells) have recently been shown to control liver-stage infections, scientists embarked on a mRNA-based vaccine strategy to induce liver Trm cells to prevent malaria.
    [Nature Immunology]

    AbstractPress Release
    PUBLICATIONSRanked by the impact factor of the journal

    Durable Reprogramming of Neutralizing Antibody Responses Following Omicron Breakthrough Infection

    Investigators reported the dynamics and durability of recalled spike-specific humoral immunity following Omicron BA.1 or BA.2 breakthrough infection, with longitudinal sampling up to eight months after infection.
    [Science Advances]

    Full Article

    Structural Definition of HLA Class II-Presented SARS-CoV-2 Epitopes Reveals a Mechanism to Escape Pre-Existing CD4+ T Cell Immunity

    Researchers demonstrated that the immunogenicity of SARS-CoV-2 peptides, in the context of the model allotype HLA-DR1, did not correlate with their binding affinity to the HLA heterodimer.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Balance between Maternal Antiviral Response and Placental Transfer of Protection in Gestational SARS-CoV-2 Infection

    By analyzing mother:neonate dyads from second and third trimester SARS-CoV-2 infections, the authors showed that neutralizing antibodies were infrequently detected in cord blood.
    [JCI Insight]

    AbstractGraphical Abstract

    IKK2/NFkB Signaling Controls Lung Resident CD8+ T Cell Memory during Influenza Infection

    Scientists found that enhancing NFkB signaling in T cells once memory to influenza was established, increased pro-survival Bcl-2 and CD122 levels thus boosting lung CD8+ T cell tissue resident memory maintenance.
    [Nature Communications]

    Full Article

    SuPAR Mediates Viral Response Proteinuria by Rapidly Changing Podocyte Function

    Researchers characterized a new type of proteinuria originating as part of a viral response. Inoculation of SARS-CoV-2 caused increased soluble urokinase receptor (suPAR) levels and glomerulopathy in African green monkeys.
    [Nature Communications]

    Full Article

    The Helicase-Like Transcription Factor Redirects the Autophagic Flux and Restricts Human T Cell Leukemia Virus Type 1 Infection

    The authors described a mechanism of restriction against human T cell leukemia virus type 1 by the helicase-like transcription factor.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Abstract

    CD4+ T Cells Regulate Sickness-Induced Anorexia and Fat Wasting during a Chronic Parasitic Infection

    Researchers examined the role of the adaptive immune response in adipose tissue wasting and cachexia using a murine model of the chronic parasitic infection Trypanosoma brucei.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Myeloid-Derived Suppressor Cells Impair CD4+ T Cell Responses during Chronic Staphylococcus aureus Infection via Lactate Metabolism

    Investigators elucidated the mechanisms underlying the suppressive effect exerted by myeloid-derived suppressor cells on CD4+ T cells during chronic S. aureus infection.
    [Cellular and Molecular Life Sciences]

    Full Article
    Free E-Book: Genome Editing Applications for Disease Modeling and Cell Therapy.
    REVIEWS

    Understanding Virus–Host Interactions in Tissues

    The author highlights methods to study virus–host interactions in the infection microenvironment, providing an overview of emerging technologies used to study the host response to viral infections.
    [Nature Microbiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    ‘An Unexpected Outcome’: Bavarian Nordic Crashes Out of RSV Race as Vaccine Fails Phase III Trial

    Bavarian Nordic has crashed out of the respiratory syncytial virus (RSV) vaccine race, with a phase III failure in older adults sending the company’s plans—and stock price—into a tailspin.
    [Fierce Biotech]

    Press Release
    FEATURED EVENT

    The Human Microbiome

    September 20 – 23, 2023
    EMBL Heidelberg and Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – HIV Persistence and Neuroimmunology

    University of California, Berkeley – Berkeley, California, United States

    Postdoctoral Fellow – Brain Disease Mechanisms

    Harvard Medical School-Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Associate – Programmed Cell Death and Viral Infections

    Fox Chase Cancer Center – Philadelphia, Pennsylvania, United States

    Faculty Positions – Infectious Diseases

    Cleveland Clinic – Port Saint Lucie, Florida, United States

    Faculty Positions – Advanced Immunochemical Studies

    ShanghaiTech University – Shanghai, China

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immunology of Infectious Disease News Twitter