Immunology of Infectious Disease News Volume 11.30 | Aug 2 2023

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    2023-08-02 | IIDN 11.30


    Immunology of Infectious Disease News by STEMCELL Technologies
    Vol. 11.30 – 2 August, 2023
    TOP STORY

    Human Anti-N1 Monoclonal Antibodies Elicited by Pandemic H1N1 Virus Infection Broadly Inhibit HxN1 Viruses In Vitro and In Vivo

    The monoclonal antibodies provided robust protection from lethal challenge with human H1N1 and avian H5N1 viruses in mice, and both targeted an epitope on the lateral face of neuraminidase.
    [Immunity]

    AbstractGraphical Abstract
    Tools and products for your COVID-19 research.
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Mouse Adaptation Selects Virulence Mutations That Cause TNF-Driven Age-Dependent Severe Disease with Human Correlates

    Scientists passaged a naturally occurring near-ancestral SARS-CoV-2 variant and identified viral genomic mutations coinciding with the acquisition of severe disease in young adult mice and lethality in aged animals.
    [Proceedings Of The National Academy Of Sciences Of The United States Of America]

    Full Article

    SARS-CoV-2 Uses CD4 to Infect T Helper Lymphocytes

    Investigators showed that SARS-CoV-2 infected human CD4+ T helper cells, but not CD8+ T cells, and was present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients.
    [eLife]

    Full Article

    Comparison of Infection and Human Immune Responses of Two SARS-CoV-2 Strains in a Humanized hACE2 NIKO Mouse Model

    Researchers described a humanized human angiotensin-converting enzyme-2 (hACE2) NOD-SCID IL2Rγ−/− (NIKO) mouse model and compared infection with ancestral and mutant strains of SARS-CoV-2.
    [Scientific Reports]

    Full Article

    Some Aspects of the Life of SARS-CoV-2 ORF3a Protein in Mammalian Cells

    By developing an APEX2-based proximity labeling assay, the authors uncovered proteins proximal to ORF3a, suggesting that ORF3a recruited some host proteins to weaken the cell.
    [Heliyon]

    Full Article

    Cellular State Landscape and Herpes Simplex Virus Type 1 Infection Progression Are Connected

    To study the multimodal response of single human cells to herpes simplex virus type 1 infection, investigators mapped high-dimensional viral and cellular state spaces throughout the infection.
    [Nature Communications]

    Full Article

    Type I Interferons Drive MAIT Cell Functions against Bacterial Pneumonia

    Researchers used Klebsiella pneumoniae as a model of bacterial pneumonia and demonstrated that mucosal-associated invariant T (MAIT) cell activation is independent of MR1 and primarily driven by type I interferons.
    [Journal of Experimental Medicine]

    Full Article
    Graphical
    Abstract

    Enolase 1 of Candida albicans Binds Human CD4+ T Cells and Modulates Naïve and Memory Responses

    To obtain a better understanding of the biology behind life-threatening fungal infections caused by Candida albicans, scientists conducted an in silico screening for fungal and host protein interaction partners.
    [European Journal of Immunology]

    Abstract

    Perturbations in Neural Stem Cell Function during a Neurotropic Viral Infection in Juvenile Mice

    Using a juvenile mouse model of measles virus infection, where only mature neurons in the brain are infected, researchers defined the effects of the antiviral immune response on neural stem cells from the juvenile to adult stages of life.
    [Journal of Neurochemistry]

    AbstractGraphical Abstract
    Resources for Your T Cell Therapy Research
    REVIEWS

    Apolipoprotein E and Viral Infection: Risks and Mechanisms

    Scientists summarize the emerging relationship between apolipoprotein E (ApoE) and viral infection, discuss the potential mechanisms, and identify future directions that may advance the understanding of the link between ApoE and viral infection.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract
    INDUSTRY AND POLICY NEWS

    NIH Selects Dr. Jeanne Marrazzo as Director of the National Institute of Allergy and Infectious Diseases

    Lawrence A. Tabak, D.D.S., Ph.D., acting director for the National Institutes of Health, has named Jeanne M. Marrazzo, M.D., as director of NIH’s National Institute of Allergy and Infectious Diseases.
    [National Institutes of Health]

    Press Release

    Senate Panel Approves 2% Bump for NIH Budget in 2024

    Although below the rate of biomedical inflation, it is far more generous than a corresponding House of Representatives bill that would slash NIH’s budget by 6%.
    [Science Insider]

    Press Release
    FEATURED EVENT

    Nature Forum on Translational Aspects of Infectious Diseases

    September 14, 2023
    Seogwipo, South Korea

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Appointee – Virologist/Molecular Biologist

    Sandia National Laboratories – Livermore, California, United States

    Postdoctoral Position – HIV Persistence and Neuroimmunology

    University of California, Berkeley – Berkeley, California, United States

    Postdoctoral Fellow – Brain Disease Mechanisms

    Harvard Medical School-Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Associate – Programmed Cell Death and Viral Infections

    Fox Chase Cancer Center – Philadelphia, Pennsylvania, United States

    Faculty Positions – Infectious Diseases

    Cleveland Clinic – Port Saint Lucie, Florida, United States

    > See All Jobs

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